Archivos de Zootecnia. Editorial Report 2016

Archivos de Zootecnia reached its 252 issue during 2016. In the present editorial report, we address the facts and figures derived from the editorial process during the past yearly editorial cycle. The updates carried out on the journal mainly head towards the successful implementation of the Open Journal System on its new website (https://www.uco.es/ucopress/az/index.php/az) from September 2016, and the changes in the Editorial Office aim at enhancing the scientific relevance of the journal through the use of new channels available which may enable a greater distribution among the scientific community. A total of 362 manuscripts coming from 21 countries. Although Brazil was still the most contributing country the percentage of submissions slightly decreased (69.45%) in favour of an increase of the submissions by authors from other countries. Therefore, the most frequently used language in the manuscripts was Portuguese, followed by Spanish, English and French. 93 works were published in 2016: 57 articles, 26 short notes and 10 reviews. Published papers came from 16 countries. The two main topics the articles were about were Feeding and food (n=27; 29.03%) and Breeding and genetics (n=20; 21.50%); while the most frequent species the works dealt with was cattle (n=77; 21.27%) followed by sheep (n=62; 17.12%). Editorial times between the reception and publication of the manuscripts have comparatively improved according to the results showed in previous years’ reports.Archivos de Zootecnia alcanzó su número 252 en 2016. En el presente Informe Editorial se recogen los hechos y cifras derivadas del proceso editorial durante el pasado ciclo editorial anual. Las actualizaciones llevadas a cabo en la revista están principalmente encaminadas a la implementación satisfactoria del sistema Open Journal en su nueva web (https://www.uco.es/ucopress/az/index.php/az) desde septiembre de 2016, y los cambios en la Oficina Editorial cuyo objetivo se basa en mejorar la relevancia científica por medio del uso de los nuevos canales disponibles que pueden habilitar una mayor distribución entre la comunidad científica. Se recibieron un total de 362 manuscritos procedentes de 21 países. Aunque Brasil fue aún el país que contribuyó con el mayor número de manuscritos, los envíos ligeramente descendieron (69,45%) en favor de un aumento de los envíos de otros países. Por tanto, el idioma más frecuentemente utilizado fue el portugués, seguido del español, el inglés y el francés. 93 trabajos fueron publicados en 2016: 57 artículos, 26 notas cortas y 10 revisiones. Los trabajos publicados procedían de 16 países. Los dos temas principales objeto de publicación fueron Alimentación y Alimentos (n=27; 29,03%) y Razas y Genética (n=20; 21,50%); mientras que la principal especie sobre la que se publicó fue la especie bovina (n=77; 21,27%). Los tiempos editoriales entre la recepción y publicación de los trabajos han mejorado con respecto a los últimos años de acuerdo a los resultados mostrados en informes editoriales previos

Defining the role of APC in the mitotic spindle checkpoint in vivo:APC-deficient cells are resistant to Taxol

Mutations in the adenomatous polyposis coli (APC) tumour suppressor are the key initiating event of colorectal cancer. Although the control of WNT signalling is well established as a central tumour-suppressive function, the significance of APC in regulating chromosome instability is less well established. In this study, we test whether APC-deficient cells have a functional spindle assembly checkpoint (SAC) in vivo by examining the response of these cells to Taxol and Vinorelbine. We also show for the first time that APC deficiency compromises the arrest response to Taxol in vivo. This effect is independent of the role that APC has in WNT signalling. At higher levels of Taxol, APC-deficient cells arrest as efficiently as wild-type cells. Importantly, this dose of Taxol strongly suppresses intestinal tumourigenesis in models of benign (APC(Min/+) mouse) and invasive (AhCreER(+) APC(fl/+) PTENfl/fl) cancer. In contrast to intestinal enterocytes with a general SAC defect because of Bub1 (budding uninhibited by benzimidazole 1) deletion, APC-deficient enterocytes arrest equivalently to wild type when treated with Vinorelbine. This suggests that the failed arrest in response to Taxol is because of a specific defect in microtubule stabilization following Taxol treatment rather than a general role of the APC protein in the mitotic spindle checkpoint. In summary, this study clarifies the role of APC as a mitotic spindle checkpoint protein in vivo and shows that APC-deficient cells have a compromised response to Taxol