Macrophages in Breast Cancer: Do Involution Macrophages Account for the Poor Prognosis of Pregnancy-Associated Breast Cancer?

Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Recently, post-pregnancy mammary involution has been characterized as having a wound healing signature. We have proposed the involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional. Macrophage influx is one of the prominent features of the involuting gland, identifying the macrophage a potential instigator of tumor progression and a novel target for breast cancer treatment and prevention

Positioning Patronage: Lanyer's Salve Deus Rex Judæorum and the Countess of Cumberland in Time and Place

This article places the composition and publication of Aemilia Lanyer's Salve Deus Rex Judæorum within the context of particular periods in the life of Margaret Russell, Countess of Cumberland and her daughter, Anne Clifford, Countess of Dorset. Lanyer's use of mirroring, shared discourse, possible worlds and reconstruction of memory all relate to these periods and were designed to engage the interest of Russell and Clifford. Through the identification of the period of the women's stay in Cookham in 1604, Lanyer's poetic strategies – directly appealing to Russell – can be identified. Lanyer's decision to publish her verse collection in 1610 was also influenced by events in the lives of Russell and Clifford, thus providing insight into Lanyer's canny understanding of patronage in the period

Calendar of state papers, Colonial series ...

Eastern series continued in the calendars published by the India office.Editors: [v. 1-10] W. N. Sainsbury (with J. W. Fortescue, [v. 10])-- [v. 11-16] J. W. Fortescue. -- [v. 17-40] Cecil Headlam (with A. P. Newton, [v. 38-40]) -- K.G. Davies [v. 43-].Contents: [v. 1, 5, 7, 9-] America and West Indies, 1574/1660-1733. v. -- [v. 2-4] East Indies, China and Japan, 1513/1616-1622/1624. 3 v. -- [v. 6] East Indies, China and Persia, 1625/1629. 1 v. -- [v. 8] East Indies and Persia, 1630/1634. 1 v.Mode of access: Internet