A practical guideline for intracranial volume estimation in patients with Alzheimer’s disease

Background Intracranial volume (ICV) is an important normalization measure used in morphometric analyses to correct for head size in studies of Alzheimer Disease (AD). Inaccurate ICV estimation could introduce bias in the outcome. The current study provides a decision aid in defining protocols for ICV estimation in patients with Alzheimer disease in terms of sampling frequencies that can be optimally used on the volumetric MRI data, and the type of software most suitable for use in estimating the ICV measure. Methods Two groups of 22 subjects are considered, including adult controls (AC) and patients with Alzheimer Disease (AD). Reference measurements were calculated for each subject by manually tracing intracranial cavity by the means of visual inspection. The reliability of reference measurements were assured through intra- and inter- variation analyses. Three publicly well-known software packages (Freesurfer, FSL, and SPM) were examined in their ability to automatically estimate ICV across the groups. Results Analysis of the results supported the significant effect of estimation method, gender, cognitive condition of the subject and the interaction among method and cognitive condition factors in the measured ICV. Results on sub-sampling studies with a 95% confidence showed that in order to keep the accuracy of the interleaved slice sampling protocol above 99%, the sampling period cannot exceed 20 millimeters for AC and 15 millimeters for AD. Freesurfer showed promising estimates for both adult groups. However SPM showed more consistency in its ICV estimation over the different phases of the study. Conclusions This study emphasized the importance in selecting the appropriate protocol, the choice of the sampling period in the manual estimation of ICV and selection of suitable software for the automated estimation of ICV. The current study serves as an initial framework for establishing an appropriate protocol in both manual and automatic ICV estimations with different subject populations

A probabilistic approach for pediatric epilepsy diagnosis using brain functional connectivity networks

Background The lives of half a million children in the United States are severely affected due to the alterations in their functional and mental abilities which epilepsy causes. This study aims to introduce a novel decision support system for the diagnosis of pediatric epilepsy based on scalp EEG data in a clinical environment. Methods A new time varying approach for constructing functional connectivity networks (FCNs) of 18 subjects (7 subjects from pediatric control (PC) group and 11 subjects from pediatric epilepsy (PE) group) is implemented by moving a window with overlap to split the EEG signals into a total of 445 multi-channel EEG segments (91 for PC and 354 for PE) and finding the hypothetical functional connectivity strengths among EEG channels. FCNs are then mapped into the form of undirected graphs and subjected to extraction of graph theory based features. An unsupervised labeling technique based on Gaussian mixtures model (GMM) is then used to delineate the pediatric epilepsy group from the control group. Results The study results show the existence of a statistically significant difference (p \u3c 0.0001) between the mean FCNs of PC and PE groups. The system was able to diagnose pediatric epilepsy subjects with the accuracy of 88.8% with 81.8% sensitivity and 100% specificity purely based on exploration of associations among brain cortical regions and without a priori knowledge of diagnosis. Conclusions The current study created the potential of diagnosing epilepsy without need for long EEG recording session and time-consuming visual inspection as conventionally employed

Longitudinal Control for Connected and Automated Vehicles in Contested Environments

The Society of Automotive Engineers (SAE) defines six levels of driving automation, ranging from Level 0 to Level 5. Automated driving systems perform entire dynamic driving tasks for Levels 3–5 automated vehicles. Delegating dynamic driving tasks from driver to automated driving systems can eliminate crashes attributed to driver errors. Sharing status, sharing intent, seeking agreement, or sharing prescriptive information between road users and vehicles dedicated to automated driving systems can further enhance dynamic driving task performance, safety, and traffic operations. Extensive simulation is required to reduce operating costs and achieve an acceptable risk level before testing cooperative automated driving systems in laboratory environments, test tracks, or public roads. Cooperative automated driving systems can be simulated using a vehicle dynamics simulation tool (e.g., CarMaker and CarSim) or a traffic microsimulation tool (e.g., Vissim and Aimsun). Vehicle dynamics simulation tools are mainly used for verification and validation purposes on a small scale, while traffic microsimulation tools are mainly used for verification purposes on a large scale. Vehicle dynamics simulation tools can simulate longitudinal, lateral, and vertical dynamics for only a few vehicles in each scenario (e.g., up to ten vehicles in CarMaker and up to twenty vehicles in CarSim). Conventional traffic microsimulation tools can simulate vehicle-following, lane-changing, and gap-acceptance behaviors for many vehicles in each scenario without simulating vehicle powertrain. Vehicle dynamics simulation tools are more compute-intensive but more accurate than traffic microsimulation tools. Due to software architecture or computing power limitations, simplifying assumptions underlying convectional traffic microsimulation tools may have been a necessary compromise long ago. There is, therefore, a need for a simulation tool to optimize computational complexity and accuracy to simulate many vehicles in each scenario with reasonable accuracy. This research proposes a traffic microsimulation tool that employs a simplified vehicle powertrain model and a model-based fault detection method to simulate many vehicles with reasonable accuracy at each simulation time step under noise and unknown inputs. Our traffic microsimulation tool considers driver characteristics, vehicle model, grade, pavement conditions, operating mode, vehicle-to-vehicle communication vulnerabilities, and traffic conditions to estimate longitudinal control variables with reasonable accuracy at each simulation time step for many conventional vehicles, vehicles dedicated to automated driving systems, and vehicles equipped with cooperative automated driving systems. Proposed vehicle-following model and longitudinal control functions are verified for fourteen vehicle models, operating in manual, automated, and cooperative automated modes over two driving schedules under three malicious fault magnitudes on transmitted accelerations

Detection of Fault Data Injection Attack on UAV Using Adaptive Neural Network

AbstractA resilient and secure control system should be designed to be as safe and robust as possible in face of different types of attacks such as fault data injection (FDI) attacks; thus, nowadays, the control designers should also consider the probable attacks in their control design from the beginning. For this reason, detection of intentional faults and cyber-attacks attracts a great concern among researchers. This issue plays a great role in the safety of unmanned aerial vehicles (UAVs) due to the need of continuous supervision and control of these systems. In order to have a cyber-attack tolerant (CAT) controller, the attack and the type of attack should be detected in the first step. This paper introduces a new algorithm to detect fault data injection attack in UAV. An adaptive neural network is used to detect the injected faults in sensors of an UAV. An embedded Kalman filter (EKF) is used for online tuning of neural networks weights; these online tuning makes the attack detection faster and more accurate. The simulation results show that the proposed method can successfully detect FDI attacks applied to an UAV