99 research outputs found
Effective meson masses, effective meson-nucleon couplings and neutron star radii
Using the generalized mean field theory, we have studied the relation among
the effective meson masses, the effective meson-nucleon couplings and the
equation of state (EOS) in asymmetric nuclear matter. If the effective
omega-meson mass becomes smaller at high density, the EOS becomes stiffer.
However, if we require that the omega-meson mean field is proportional to the
baryon density, the effective omega-nucleon coupling automatically becomes
smaller at the same time as the effective omega-meson mass becomes smaller.
Consequently, the EOS becomes softer. A similar relation is found for the
effective rho-meson mass and the effective rho-nucleon coupling. We have also
studied the relation among the effective meson masses, the effective
meson-nucleon couplings and a radius R of a neutron star. The R depends
somewhat on the value of the effective omega-meson mass and the effective
omega-nucleon coupling.Comment: 29pages, 24 figure
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis
Neutrophils are highly motile leukocytes, and they play important roles in the innate immune response to invading pathogens. Neutrophil chemotaxis requires Rac activation, yet the Rac activators functioning downstream of chemoattractant receptors remain to be determined. We show that DOCK2, which is a mammalian homologue of Caenorhabditis elegans CED-5 and Drosophila melanogaster Myoblast City, regulates motility and polarity during neutrophil chemotaxis. Although DOCK2-deficient neutrophils moved toward the chemoattractant source, they exhibited abnormal migratory behavior with a marked reduction in translocation speed. In DOCK2-deficient neutrophils, chemoattractant-induced activation of both Rac1 and Rac2 were severely impaired, resulting in the loss of polarized accumulation of F-actin and phosphatidylinositol 3,4,5-triphosphate (PIP3) at the leading edge. On the other hand, we found that DOCK2 associates with PIP3 and translocates to the leading edge of chemotaxing neutrophils in a phosphatidylinositol 3-kinase (PI3K)âdependent manner. These results indicate that during neutrophil chemotaxis DOCK2 regulates leading edge formation through PIP3-dependent membrane translocation and Rac activation
Blockade of constitutively activated ERK signaling enhances cytotoxicity of microtubule-destabilizing agents in tumor cells.
The extracellular signal-regulated kinase (ERK) signaling pathway is constitutively activated in many human tumor cell types. Given the cytoprotective role of this pathway, we examined whether its specific blockade might sensitize human tumor cells to the induction of apoptosis by various anticancer drugs. Although blockade of ERK signaling alone did not induce substantial cell death, it resulted in marked and selective enhancement of the induction of apoptosis by microtubule-destabilizing agents in tumor cells in which the ERK pathway is constitutively activated. The synergistic activation of c-Jun NH(2)-terminal kinase by the combination of an ERK pathway inhibitor and a microtubule-destabilizing agent appeared to be responsible, at least in part, for this effect. These results suggest that administration of the combination of an ERK pathway inhibitor and a microtubule-destabilizing agent is a potential chemotherapeutic strategy for the treatment of tumor cells with constitutive activation of the ERK pathway
EGUIDE project and treatment guidelines
Aim: Although treatment guidelines for pharmacological therapy for schizophrenia and major depressive disorder have been issued by the Japanese Societies of Neuropsychopharmacology and Mood Disorders, these guidelines have not been well applied by psychiatrists throughout the nation. To address this issue, we developed the âEffectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)â integrated education programs for psychiatrists to disseminate the clinical guidelines. Additionally, we conducted a systematic efficacy evaluation of the programs.
Methods: Four hundred thirteen out of 461 psychiatrists attended two 1âday educational programs based on the treatment guidelines for schizophrenia and major depressive disorder from October 2016 to March 2018. We measured the participantsâ clinical knowledge of the treatment guidelines using selfâcompleted questionnaires administered before and after the program to assess the effectiveness of the programs for improving knowledge. We also examined the relation between the participantsâ demographics and their clinical knowledge scores.
Results: The clinical knowledge scores for both guidelines were significantly improved after the program. There was no correlation between clinical knowledge and participant demographics for the program on schizophrenia; however, a weak positive correlation was found between clinical knowledge and the years of professional experience for the program on major depressive disorder.
Conclusion: Our results provide evidence that educational programs on the clinical practices recommended in guidelines for schizophrenia and major depressive disorder might effectively improve participantsâ clinical knowledge of the guidelines. These data are encouraging to facilitate the standardization of clinical practices for psychiatric disorders
LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance
Recent articles have reported an association between fatty liver disease and systemic insulin resistance in humans, but the causal relationship remains unclear. The liver may contribute to muscle insulin resistance by releasing secretory proteins called hepatokines. Here we demonstrate that leukocyte cell-derived chemotaxin 2 (LECT2), an energy-sensing hepatokine, is a link between obesity and skeletal muscle insulin resistance. Circulating LECT2 positively correlated with the severity of both obesity and insulin resistance in humans. LECT2 expression was negatively regulated by starvation-sensing kinase adenosine monophosphate-activated protein kinase in H4IIEC hepatocytes. Genetic deletion of LECT2 in mice increased insulin sensitivity in the skeletal muscle. Treatment with recombinant LECT2 protein impaired insulin signaling via phosphorylation of Jun NH2-terminal kinase in C2C12 myocytes. These results demonstrate the involvement of LECT2 in glucose metabolism and suggest that LECT2 may be a therapeutic target for obesity-associated insulin resistance. © 2014 by the American Diabetes Association
Sequential Changes in Histochemical Localization and Releasability of Epoxide Hydrolase during Experimetal Hepatocarcinogenesis
Sequential Changes in Histochemical Localization and Releasability of Epoxide Hydrolase during Experimetal Hepatocarcinogenesis
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