Attitudes of patients and physicians to insulin therapy in Japan: an analysis of the Global Attitude of Patients and Physicians in Insulin Therapy study

<p><b>Background</b>: The barriers to insulin therapy perceived by Japanese patients with diabetes and their physicians are unclear.</p> <p><b>Research design and methods</b>: We performed sub-analyses of the Global Attitude of Patients and Physicians in Insulin Therapy (GAPP™) study, which included 100 Japanese physicians (of 1250 participating physicians) and 150 Japanese patients (of 1530 patients) who participated in Internet surveys (physicians) or computer-assisted telephone surveys (patients) across eight countries in 2010. We compared the results of Japanese participants with those obtained for the other seven countries.</p> <p><b>Results</b>: Overall, 44% of the Japanese patients reported omission or non-adherence to insulin, a greater value than that reported in other countries. Japanese physicians reported that non-adherence to insulin was driven by their patients’ lifestyles. A greater proportion of patients had a history of hypoglycemia in Japan than in other countries. Most of the physicians (94%) and patients (84%) in Japan reported that the currently available insulin treatment regimens do not fit the diverse lifestyles of patients.</p> <p><b>Conclusions</b>: Many Japanese patients receiving insulin therapy omit or do not adhere to insulin, possibly because of fear of hypoglycemia, or for lifestyle reasons. Insulin regimens that reduce the risk of hypoglycemia without interfering with patients’ lifestyles are needed.</p

Long-term Effect of Color Record Method in Self-monitoring of Blood Glucose on Metabolic Parameters in Type 2 Diabetes: A 2-year Follow-up of the Color IMPACT Study

<p></p><p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>. </b><a href="https://link.springer.com/article/10.1007/s13300-018-0457-6">https://link.springer.com/article/10.1007/s13300-018-0457-6</a></p><p></p><p></p><p> </p><p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p><br><p></p

MOESM2 of Efficacy and safety of canagliflozin in combination with insulin: a double-blind, randomized, placebo-controlled study in Japanese patients with type 2 diabetes mellitus

Additional file 2: Table S1. Time of onset of hypoglycemia (safety analysis set)

Social Orientation and Diabetes-Related Distress in Japanese and American Patients with Type 2 Diabetes

<div><p>Objective</p><p>Recent evidence in cultural and social psychology suggests Eastern cultures' emphasis on harmony and connection with others and Western cultures' emphasis on self-direction and autonomy. In Eastern society, relational harmony is closely linked to people's well-being. The impact of this cultural and social orientation on diabetes-related distress was investigated.</p><p>Research Design and Methods</p><p>Japanese and American patients with type 2 diabetes were surveyed by well-established questionnaire in Japan and in the United States, respectively. The association of personal values for interdependence, perceived emotional support, and the Problem Areas in Diabetes scale (PAID) were analyzed.</p><p>Results</p><p>A positive correlation between interdependence and PAID (<i>r</i> = 0.18; <i>P</i> = 0.025) and a negative correlation between perceived emotional support and PAID (<i>r</i> = − 0.24; <i>P</i> = 0.004) were observed after adjustments for other factors in Japanese data (<i>n</i> = 149), but not in American data (<i>r</i> = 0.00; <i>P</i> = 0.990, <i>r</i> = 0.02; <i>P</i> = 0.917, respectively, <i>n</i> = 50). In Japanese data, the three-factor structure of PAID (negative feelings about total life with diabetes, about living conditions with diabetes, and about treatment of diabetes) was identified, and interdependence showed significant positive correlations with the first and second factors and perceived emotional support showed significant negative correlations with all three factors of PAID.</p><p>Conclusions</p><p>These results suggest that personal values for interdependence may be linked to the level of diabetes-related distress and that the distress may be relieved by perception of emotional support, especially in an interdependent cultural context.</p></div

Characteristics of patients.

<p>Characteristics of patients.</p

Factor loadings of the 20 items of PAID for the three extracted factors after promax rotation in Japanese.

<p>Factor loadings of the 20 items of PAID for the three extracted factors after promax rotation in Japanese.</p

Correlations between diabetes-related distress, interdependence and perceived emotional support.

<p>Correlations between diabetes-related distress, interdependence and perceived emotional support.</p

Distribution plots and Pearson's correlation coefficients to show the association between PAID and interdependence after adjusting for PES, self-esteem, sex, age and education level in Japanese (A) and Americans (B), between PAID and PES after adjusting for interdependence, self-esteem, sex, age and education level in Japanese (C) and Americans (D). PAID, the Problem Areas in Diabetes; PES, perceived emotional support.

<p>Distribution plots and Pearson's correlation coefficients to show the association between PAID and interdependence after adjusting for PES, self-esteem, sex, age and education level in Japanese (A) and Americans (B), between PAID and PES after adjusting for interdependence, self-esteem, sex, age and education level in Japanese (C) and Americans (D). PAID, the Problem Areas in Diabetes; PES, perceived emotional support.</p

Factors Affecting Canagliflozin-Induced Transient Urine Volume Increase in Patients with Type 2 Diabetes Mellitus

<p><strong>Article full text</strong></p> <p><br> The full text of this article can be found <a href="https://link.springer.com/article/10.1007/s12325-016-0457-8"><b>here</b>.</a><br> <br> <strong>Provide enhanced digital features for this article</strong><br> If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact <u>[email protected]</u>.<br> <br> The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.<br> <br> Other enhanced features include, but are not limited to:<br> • Slide decks<br> • Videos and animations<br> • Audio abstracts<br> • Audio slides<u></u></p

Characteristics of single BK channels in SNr neurons.

<p>(A) Representative recordings of single-channel currents at transmembrane potentials of −60 mV to 60 mV and [Ca²⁺]_i of 100 µM. The solid red line denotes the closed state and the dotted red line denotes the open state. (B) The relationship between single channel currents and holding membrane potential. The <i>I</i>–<i>V</i> curve was obtained by fitting a linear equation to the data. (C) The relationship between <i>P</i>_open and transmembrane potential. The <i>P</i>_open-<i>V_m</i> curve was obtained by fitting the Boltzmann equation to the data. (D) The relationship between <i>P</i>_open and [Ca²⁺]_i. The <i>P</i>_open-[Ca²⁺]_i curve was obtained by fitting the Hill equation to the data. (E) The effect of intracellular free calcium on conductance of the channel at membrane potentials of –60 mV and +60 mV. ^***, <i>P</i><0.005; ^****, <i>P</i><0.001; ^*****, <i>P</i><0.0001.</p