XÁC ĐỊNH TẦNG CHỨA VÀ QUAN TRẮC BIẾN ĐỘNG MÔI TRƢỜNG NƢỚC DƢỚI ĐẤT TẠI KHU CÔNG NGHIỆP BẮC THĂNG LONG - QUANG MINH, HÀ NỘI BẰNG PHƢƠNG PHÁP ĐỊA VẬT LÝ THỦY VĂN

Geophysical  methods  were  applied  for  hydrogeological  targets  in  many  countries  including  Vietnam.  This  paper resents  results  of  using  complex  geophysical  techniques  as  well  as  2D  electrical  resistivity  imaging  (ERI),  vertical electrical  sounding  (VES),  very  low  frequency  (VLF)  and  seismic  refraction  for  geological  structure  investigation  to aquifers locate and to assess of hydrogeological condition for groundwater potential in North Thanglong and Quangminh industrial zones, Hanoi, Vietnam. The locations of two aquifers are determined by their depth and thickness on the basis of resistivity and seismic velocity values which were proved by stratifications of three boreholes to 40-60m of depth on study area. There are connecting from surface water to shallow aquifer by hydraulic windows from VLF data. The deeper aquifer can be considered as potential groundwater for supplying in the area. Groundwater level, electrical conductivity and  water  temperature  were  measured  in  six  monitoring  wells,  complemented  by  anion,  cation  and  stable  isotope analyses of ground and surface water. This study also reviews, compiles and comprehensively analyzes spatiotemporal variations of hydrological and hydrogeological characteristics of shallow and deep groundwater aquifers in area and in nearby Red River water. The results show that groundwater in both shallow and deep aquifers was fresh, but mainly calcium-bicarbonate type. With the goal of devising sustainable water use regulations, more research must be directed toward long-term monitoring of groundwater and surface water quality, as well as toward detailed investigation of the hydraulic characteristics of local aquifers in the study area.ReferencesAGI, 2003. The SuperSting with Swift automatic resistivity and IP system instruction manual, Advanced Geosciences, Inc., Austin, Texas, U.S.A.Lê Đức An, 1996. 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Hori K., Tanabe S., Saito Y., Haruyama S., Viet N., Kitamura A., 2004. Delta initiation and Holocene sea-level change: Example from the Red river delta, Vietnam. Sed. Geol., 164, 237-249. Hubbard S.S., Rubin Y., 2000. Hydrogeological parameter estimation using geophysical data: a review of selected techniques. J. of Contaminant Hydrology 45, 3-34. Hubbard S.S., Rubin Y.,Majer E., 1999. Spatial Correlation Structure Estimation Using Geophysical and Hydrogeological Data. Water Resources Research, 35, 1809-1825. Karous  M.,  Hjelt S.E., 1983. Linear  filtering  of  VLF  dip-angle measurements. Geophysical Prospecting, 31, 782-894. Keller G.V. and Frischknecht F.C., 1966. Electrical methods in geoelectric prospecting, Pergamon Press, Inc., 517. Loke. M. H., 2004. Tutoral: 2-D and 3-D electrical imaging survey. Trần Nghi, Ngô Quang Toàn, 1991. Đặc điểm chu kỳ trầm tích và lịch sử tiến hóa địa chất Đệ Tứ của châu thổ Sông Hồng, Tạp chí Địa chất số 206-207, tr. 65-77. Ogilvy, R.D. and Lee, A.C., 1991. Interpretation of VLF-EM in-phase data using current density pseudo-sections. Geophysical Prospecting, 39, 567-580. Owen, S.J.; Jones, N.L., and Holland, J.P., 1996. A comprehensive modeling environment for the simulation of groundwater flow and transport. Engineering with Computers 12 (3-4), 235-242. doi:10.1007/BF01198737. F. F. Pedersen, N.V. Giang, 2002. Saltwater Intrusion in Aquifer-TEM Mapping around Gialoc-Haiduong, Vietnam. Advances in Natural Sciences, Vol.3, No.3, 289-295.Pham V. N., D. Boyer, N. T. K. Thoa,  N.V.Giang, 1994. Deep Ground water Investigation in South Vietnam by Combined VES/MTS Methods, Ground Water, vol.32, N.4, July-August, 675-683. Rangin C, Klein M, Roques D, Le Pichon X and Trang L V, 1995. The Red river fault system in the Tonkin Gulf, Vietnam. Tectonophysics, 243; 209-222. Rubin Y. and Hubbard S.S, 2005. Hydrogeophysics, Series: Water Science and Technology Library, Springer, Vol. 50, 523. 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Guidelines for drinking water quality; Training Pack, WTO, Geneva, Switzerland.  Geophysical  methods  were  applied  for  hydrogeological  targets  in  many  countries  including  Vietnam.  This  paper presents  results  of  using  complex  geophysical  techniques  as  well  as  2D  electrical  resistivity  imaging  (ERI),  vertical electrical  sounding  (VES),  very  low  frequency  (VLF)  and  seismic  refraction  for  geological  structure  investigation  to aquifers locate and to assess of hydrogeological condition for groundwater potential in North Thanglong and Quangminh industrial zones, Hanoi, Vietnam. The locations of two aquifers are determined by their depth and thickness on the basis of resistivity and seismic velocity values which were proved by stratifications of three boreholes to 40-60m of depth on study area. There are connecting from surface water to shallow aquifer by hydraulic windows from VLF data. The deeper aquifer can be considered as potential groundwater for supplying in the area. Groundwater level, electrical conductivity and  water  temperature  were  measured  in  six  monitoring  wells,  complemented  by  anion,  cation  and  stable  isotope analyses of ground and surface water. This study also reviews, compiles and comprehensively analyzes spatiotemporal variations of hydrological and hydrogeological characteristics of shallow and deep groundwater aquifers in area and in nearby Red River water. The results show that groundwater in both shallow and deep aquifers was fresh, but mainly calcium-bicarbonate type. With the goal of devising sustainable water use regulations, more research must be directed toward long-term monitoring of groundwater and surface water quality, as well as toward detailed investigation of the hydraulic characteristics of local aquifers in the study are

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Eine Richtung der Wasserwirtschaft im Oga-Nanshu Gebiet, Akita Präfektur

Das Oga-Nanshu Gebiet steht ungefahr in der Mitte der Akita Präfektur. Das Gebietbesteht aus 12 Gemeinden, deren Flächengröße insgesamt 1.021km2 ist, und gehört nichtzu großen Niederschlagsgebieten. Der berechnete mittlere jährliche Zahlenwert des Gebietsniederschlags (N), der potentiellen Gebietsverdunstung (PET) und des Gebietswasserüberschusses(N-PET) beträgt jeweils 1.666mm, 690mm und 976mm(1941-1970). In dem zukunftigen Wassergewinnungssystem wäre die Methode der künstlichen Grundwasseranreicherung erfolgreich, die in der Düne des Gebiets mit Hilfe vom Rohwasser aus dem Hachirogata Binnensee durchgeführt wird