2 research outputs found
Neurobiologia do parkinsonismo: I. substratos neurais e neuroquĂmica dos gânglios basais
Neurobiologia do parkinsonismo: II. modelos experimentais Neurobiology of parkinsonism: II. experimental models
O emprego de modelos experimentais de parkinsonismo tem contribuĂdo nĂŁo sĂł para explicar o conhecimento das funções dos gânglios basais como tambĂ©m tem permitido o surgimento de várias hipĂłteses para explicar os processos neurodegeneratives do sistema nervoso central. Nesta revisĂŁo sĂŁo apresentados e discutidos os modelos de parkinsonismo que utilizam neurotoxins como a 6-hidroxidopamina, MPTP e o manganĂŞs.The study of experimental models of parkinsonism has contributed to the knowledge of basal ganglia functions, as well as to the establishment of several hypothesis for the explanation of the cause and expression of central neurodegenerative disorders. In this review we present and discuss several models such as 6-hydroxydopamine, MPTP and manganese, all of them widely used to characterize the behavioral, cellular and molecular mechanisms of parkinsonism