Incidence of urinary tract infection (UTI) among pregnant women in Ibadan, South-Western Nigeria

This study reports the incidence of urinary tract infections (UTIs) among 80 pregnant women attending antenatal clinics at Oluyoro Catholic Hospital (OCH), Ibadan, Nigeria, as well as the isolation and identification of the pathogens responsible for the infection. A total of 80 clean voided mid-stream urine samples were collected from pregnant women between the ages of 21-40 years. The results showed that the incidence of UTIs in this study population was 47.5%, and 38 bacterial isolates were identifiedbased on colonial morphology, microscopic characteristics, and biochemical tests. The most predominant bacterium was Escherichia coli 16 (42.1%). This was followed by Staphylococcus aureus 11 (28.9%), Klebsiella aerogenes 7 (18.4%), Pseudomonas aeruginosa 2 (5.3%), and a mixed culture of K. aerogenes and Staphylococcus aureus 2 (5.3%). Urine microscopy revealed the presence of pus cells in 15 of the urine samples collected. Two urine samples, representing 2.5% of the samples, contained yeast cells, suggesting that candidiasis was also predominant. The high incidence of UTIs reported in this study should be of great concern, as not only do UTIs pose a threat to health, but they also impose an economic and social burden due to the stigma associated with these infections

Assessment of the efficacies, potencies and bacteriological qualities of some of the antibiotics sold in Calabar, Nigeria

In this study, an assessment of the efficacies, potencies and qualities of 11 brands of 5 different antibiotics including 3 brands of ampiclox and 2 brands each of ciprofolxacin, gentamicin, rifampicin and tetracylcine sold in Calabar, South-South region of Nigeria was carried out using the agar diffusion technique (sensitivity testing). The efficacies, potencies and qualities of these antibiotics were tested against some clinical isolates which include Escherichia coli, Klebsiella  pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pyogenes in vitro. The overall mean zones of inhibition for the test organisms ranged from 33.0 – 34.7 mm, with 33 mm for E. coli, 20.9 mm for K. pneumoniae, 34.7 mm for P. aeruginosa, 31.4 mm for S. aureus and 17.6 mm for S. pyogenes. The result showed that 3 (60%) of the antibiotics (alaclox, ciprofloxacin and rifampicin) tested showed lower potency against the test organisms  compared with the standard controls. Alaclox produced  significantly (P < 0.05) lower zones of inhibition compared to the other brands of ampiclox (superclox and vitaclox) on S. aureus and S. pyogenes. However, significant differences (P = 0.007, P = 0.026, P = 0.050, P = 0.012) were observed between the zones of  inhibition of the test antibiotics and standard controls for the 3 brands of ampiclox tested on all the test organisms except for K. pneumoniae. There were also  significant differences (P = 0.038, P = 0.038, P = 0.049, P = 0.025, P = 0.032) between the zones of inhibition observed for ciprofloxacin and their standard  controls. Both brands of rifampicin (vitals and medifampi) produced significantly (P = 0.020, P = 0.038) lower zones of inhibition on E. coli and S.pyogenes   compared to their standard controls. Our result also showed there were no significant differences (P > 0.05) between the observed zones of inhibition and standard controls of the brands of gentamicin (richem) and tetracycline. These overall and mean potencies of the test antibiotics showed differences in their efficacies, potencies and qualities. This confirmed that some brands of ampiclox, ciprofloxacin and rifampicin antibiotics sold in Nigeria do not contain the acclaimed quantity of  active ingredients to exert bacteriocidal or bacteriostatic effect on common pathogens.Key words: Antibiotics, assessment, bacteriological quality, efficacy, potency, zones of inhibition

Self-medication with antibiotics for the treatment of menstrual symptoms in southwest Nigeria: a cross-sectional study

Background: Self-medication with antibiotics is an important factor contributing to the development of bacterial antibiotic resistance. The purpose of this study was to evaluate the prevalence of self-medication with antibiotics for the treatment of menstrual symptoms among university women in Southwest Nigeria. Methods: A cross-sectional survey was administered to female undergraduate and graduate students (n = 706) at four universities in Southwest Nigeria in 2008. The universities were selected by convenience and the study samples within each university were randomly selected cluster samples. The survey was self-administered and included questions pertaining to menstrual symptoms, analgesic and antibiotic use patterns, and demographics. Data were analyzed using descriptive statistics and logistic regression. Results: The response rate was 95.4%. Eighty-six percent (95% CI: 83-88%) of participants experienced menstrual symptoms, and 39% (95% CI: 36-43%) reported using analgesics to treat them. Overall, 24% (95% CI: 21-27%) of participants reported self-medicated use of antibiotics to treat the following menstrual symptoms: cramps, bloating, heavy bleeding, headaches, pimples/acne, moodiness, tender breasts, backache, joint and muscle pain. Factors associated with this usage were: lower levels of education (Odds Ratio (OR): 2.8, 95% CI: 1.1-7.1, p-value: 0.03); nonscience major (OR: 1.58, 95% CI: 1.03-2.50, p-value: 0.04); usage of analgesics (OR: 3.17, 95% CI: 2.07-4.86, p-value: <0.001); and mild to extreme heavy bleeding (OR: 1.64, 95% CI: 1.01-2.67, p-value: 0.05) and pimples/acne (OR: 1.57, 95% CI: 0.98-2.54, p-value: 0.06). Ampicillin, tetracycline, ciprofloxacin and metronidazole were used to treat the most symptoms. Doctors or nurses (6%, 95% CI: 4-7%), friends (6%, 95% CI: 4-7%) and family members (7%, 95% CI: 5-8%) were most likely to recommend the use of antibiotics for menstrual symptoms, while these drugs were most often obtained from local chemists or pharmacists (10.2%, 95% CI: 8-12%). Conclusions: This is the first formal study to report that approximately 1 out of 4 university women surveyed in Southwest Nigeria self-medicate with antibiotics to treat menstrual symptoms. This practice could provide monthly, low-dose exposures to antibiotics among users. Further studies are necessary to evaluate the impacts of selfmedication on student health