Thyroidectomy Using Pure Natural Orifice Transluminal Endoscopic Surgery in a Porcine Model

13301甲第4281号博士（医学）金沢大学博士論文要旨Abstract 以下に掲載：Artificial Organs 39(5) pp.441-445 2015. Wiley Periodicals. 共著者：Kanae Nitta, Masahiko Kawaguchi, Norihiko Ishikawa, Akishi Ooi, Go Watanab

Thyroidectomy using pure natural orifice transluminal endoscopic surgery in a porcine model

Surgical procedures for thyroid disease that provide cosmetically acceptable results are in demand. Natural orifice transluminal endoscopic surgery (NOTES) is performed through natural orifices and thus avoids incision of the body wall. This study aimed to develop an incision-free surgical procedure for thyroid lobectomy using pure NOTES with an oral approach. In six pig carcasses, an incision was made between the mandible and subcutaneous tissue under direct vision. After subcutaneous dissection and identification of the hyoid bone, the operative field was developed under endoscopic view. After the thyrohyoid membrane was identified, dissection was continued along the thyroid cartilage until the cricoid cartilage was identified and the thyroid isthmus was reached. An original retractor was inserted between dissected tissues to lift and fix the carcass. The thyroid gland was successfully removed through the incision. Similar macroscopic and histological findings were observed on the normal and treated sides, with no damage to the recurrent laryngeal nerves. The times required for securing the operative field and thyroidectomy improved with each operation. This study suggests the feasibility and safety of using pure NOTES for thyroidectomy through a subcutaneous route with an original retractor

レスベラトロール処理細胞における抗腫瘍薬の効果

Chemo-resistance to anti-cancer drugs is a major obstacle in efforts to develop a successful treatment of cancer.Resveratrol(RSV)facilitates the cellular uptake of doxorubicin through an induced down-regulation of multidrug resistance -associated protein-1(MRP1)expression.We studied whether RSV enhances the cytotoxic effect of vinblastine,vincristine,irinotecan,and etoposide in MRP1-expressing Burkitt\u27s lymphoma Raji cells.Treatment with RSV caused decrease of cell viability in a time-and dose-dependent manner,and down-regulation of MRP1 expression in Raji cells.The cytotoxic effects of vinblastine,vincristine,and etoposide increased in RSV-pretreated Raji cells,but the effect of irinotecan did not change in the cells.These results indicate that RSV enhances the cellular uptake of vinblastine,and etoposide in Raji cell