Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability

[Introduction]Osteoarthritis (OA) is a common cause of disability in older adults. We have previously reported that an agonist for subtypes EP2 of the prostaglandin E2 receptor (an EP2 agonist) promotes the regeneration of chondral and osteochondral defects. The purpose of the current study is to analyze the effect of this agonist on articular cartilage in a model of traumatic degeneration. [Methods]The model of traumatic degeneration was established through transection of the anterior cruciate ligament and partial resection of the medial meniscus of the rabbits. Rabbits were divided into 5 groups; G-S (sham operation), G-C (no further treatment), G-0, G-80, and G-400 (single intra-articular administration of gelatin hydrogel containing 0, 80, and 400 μg of the specific EP2 agonist, ONO-8815Ly, respectively). Degeneration of the articular cartilage was evaluated at 2 or 12 weeks after the operation. [Results]ONO-8815Ly prevented cartilage degeneration at 2 weeks, which was associated with the inhibition of matrix metalloproteinase-13 (MMP-13) expression. The effect of ONO-8815Ly failed to last, and no effects were observed at 12 weeks after the operation. [Conclusions]Stimulation of prostaglandin E2 (PGE2) via EP2 prevents degeneration of the articular cartilage during the early stages. With a system to deliver it long term, the EP2 agonist could be a new therapeutic tool for OA

Experimental Results for Electron Bernstein Wave Heating in the Large Helical Device

Electron cyclotron heating (ECH) using electron Bernstein waves (EBWs) was studied in the large helical device (LHD). Oblique launching of the slow extraordinary (SX-) mode from the high field side and oblique launching of the ordinary (O-) mode from the low field side were adopted to excite EBWs in the LHD by using electron cyclotron (EC) wave antennas installed apart from the plasma surface. Increases in the stored energy and electron temperature were observed for both cases of launching. These launching methods for ECH using EBWs (EBWH) is promising for high-density operation in future helical fusion devices instead of conventional ECH by normal electromagnetic modes

Recent Results from LHD Experiment with Emphasis on Relation to Theory from Experimentalist’s View

he Large Helical Device (LHD) has been extending an operational regime of net-current free plasmas towardsthe fusion relevant condition with taking advantage of a net current-free heliotron concept and employing a superconducting coil system. Heating capability has exceeded 10 MW and the central ion and electron temperatureshave reached 7 and 10 keV, respectively. The maximum value of β and pulse length have been extended to 3.2% and 150 s, respectively. Many encouraging physical findings have been obtained. Topics from recent experiments, which should be emphasized from the aspect of theoretical approaches, are reviewed. Those are (1) Prominent features in the inward shifted configuration, i.e., mitigation of an ideal interchange mode in the configuration with magnetic hill, and confinement improvement due to suppression of both anomalous and neoclassical transport, (2) Demonstration ofbifurcation of radial electric field and associated formation of an internal transport barrier, and (3) Dynamics of magnetic islands and clarification of the role of separatrix

Density Regimes of Complete Detachment and Serpens Mode in LHD

In the Large Helical Device (LHD), the hot plasma column shrinks at the high-density regime and complete detachment takes place. Hydrogen volume recombination is observed at complete detachment. This phase isself-sustained under specific experimental conditions and called the Serpens mode (self-regulated plasma edge ‘neath the last-closed-flux-surface). The Serpens mode is achieved after either rapid or slow density ramp up, and either by hydrogen or helium gas puffing. The threshold conditions for complete detachment and the Serpens mode are experimentally documented in the parameter space of heating power and density. The threshold density for the Serpens mode transition increases with ? 0.4 power of the heating power. The total radiation is shown to be not adequate to describe the threshold conditions, since it mainly includes the information of very edge region outside the hot plasma column. The operational density limit in LHD, which is sustainable in steady state, has been extended to 1.7 times as high as the Sudo density limit, by applying pellet injection to the Serpens plasmas