A review on slow earthquakes in the Japan Trench

Slow earthquakes are episodic slow fault slips. They form a fundamental component of interplate deformation processes, along with fast, regular earthquakes. Recent seismological and geodetic observations have revealed detailed slow earthquake activity along the Japan Trench—the subduction zone where the March 11, 2011, moment magnitude (Mw) 9.0 Tohoku-Oki earthquake occurred. In this paper, we review observational, experimental, and simulation studies on slow earthquakes along the Japan Trench and their research history. By compiling the observations of slow earthquakes (e.g., tectonic tremors, very-low-frequency earthquakes, and slow slip events) and related fault slip phenomena (e.g., small repeating earthquakes, earthquake swarms, and foreshocks of large interplate earthquakes), we present an integrated slow earthquake distribution along the Japan Trench. Slow and megathrust earthquakes are spatially complementary in distribution, and slow earthquakes sometimes trigger fast earthquakes in their vicinities. An approximately 200-km-long along-strike gap of seismic slow earthquakes (i.e., tectonic tremors and very-low-frequency earthquakes) corresponds with the huge interplate locked zone of the central Japan Trench. The Mw 9.0 Tohoku-Oki earthquake ruptured this locked zone, but the rupture terminated without propagating deep into the slow-earthquake-genic regions in the northern and southern Japan Trench. Slow earthquakes are involved in both the rupture initiation and termination processes of megathrust earthquakes in the Japan Trench. We then compared the integrated slow earthquake distribution with the crustal structure of the Japan Trench (e.g., interplate sedimentary units, subducting seamounts, petit-spot volcanoes, horst and graben structures, residual gravity, seismic velocity structure, and plate boundary reflection intensity) and described the geological environment of the slow-earthquake-genic regions (e.g., water sources, pressure–temperature conditions, and metamorphism). The integrated slow earthquake distribution enabled us to comprehensively discuss the role of slow earthquakes in the occurrence process of the Tohoku-Oki earthquake. The correspondences of the slow earthquake distribution with the crustal structure and geological environment provide insights into the slow-earthquake-genesis in the Japan Trench and imply that highly overpressured fluids are key to understanding the complex slow earthquake distribution. Furthermore, we propose that detailed monitoring of slow earthquake activity can improve the forecasts of interplate seismicity along the Japan Trench

A base pair at the bottom of the anticodon stem is reciprocally preferred for discrimination of cognate tRNAs by Escherichia coli lysyl- and glutaminyl-tRNA synthetases

Although the yeast amber suppressor tRNA(Tyr) is a good candidate for a carrier of unnatural amino acids into proteins, slight misacylation with lysine was found to occur in an Escherichia coli protein synthesis system. Although it was possible to restrain the mislysylation by genetically engineering the anticodon stem region of the amber suppressor tRNA(Tyr), the mutant tRNA showing the lowest acceptance of lysine was found to accept a trace level of glutamine instead. Moreover, the glutamine-acceptance of various tRNA(Tyr) transcripts substituted at the anticodon stem region varied in reverse proportion to the lysine-acceptance, similar to a ‘seesaw’. The introduction of a C31–G39 base pair at the site was most effective for decreasing the lysine-acceptance and increasing the glutamine-acceptance. When the same substitution was introduced into E.coli tRNA(Lys) transcripts, the lysine-accepting activity was decreased by 100-fold and faint acceptance of glutamine was observed. These results may support the idea that there are some structural element(s) in the anticodon stem of tRNA, which are not shared by aminoacyl-tRNA synthetases that have similar recognition sites in the anticodon, such as E.coli lysyl- and glutaminyl-tRNA synthetases

Development of an accurate classification system of proteins into structured and unstructured regions that uncovers novel structural domains: its application to human transcription factors

<p>Abstract</p> <p>Background</p> <p>In addition to structural domains, most eukaryotic proteins possess intrinsically disordered (ID) regions. Although ID regions often play important functional roles, their accurate identification is difficult. As human transcription factors (TFs) constitute a typical group of proteins with long ID regions, we regarded them as a model of all proteins and attempted to accurately classify TFs into structural domains and ID regions. Although an extremely high fraction of ID regions besides DNA binding and/or other domains was detected in human TFs in our previous investigation, 20% of the residues were left unassigned. In this report, we exploit the generally higher sequence divergence in ID regions than in structural regions to completely divide proteins into structural domains and ID regions.</p> <p>Results</p> <p>The new dichotomic system first identifies domains of known structures, followed by assignment of structural domains and ID regions with a combination of pre-existing tools and a newly developed program based on sequence divergence, taking un-aligned regions into consideration. The system was found to be highly accurate: its application to a set of proteins with experimentally verified ID regions had an error rate as low as 2%. Application of this system to human TFs (401 proteins) showed that 38% of the residues were in structural domains, while 62% were in ID regions. The preponderance of ID regions makes a sharp contrast to TFs of <it>Escherichia coli </it>(229 proteins), in which only 5% fell in ID regions. The method also revealed that 4.0% and 11.8% of the total length in human and <it>E. coli </it>TFs, respectively, are comprised of structural domains whose structures have not been determined.</p> <p>Conclusion</p> <p>The present system verifies that sequence divergence including information of unaligned regions is a good indicator of ID regions. The system for the first time estimates the complete fractioning of structured/un-structured regions in human TFs, also revealing structural domains without homology to known structures. These predicted novel structural domains are good targets of structural genomics. When applied to other proteins, the system is expected to uncover more novel structural domains.</p

トロンボポエチンシグナルはEvi1高発現急性骨髄性白血病細胞の増殖および生存を促進する

学位の種別: 論文博士審査委員会委員 : （主査）東京大学教授 岡崎 仁, 東京大学教授 四柳 宏, 東京大学准教授 滝田 順子, 東京大学准教授 山内 敏正, 東京大学講師 細谷 紀子University of Tokyo(東京大学

筋骨格ロボットによる棒高跳び実現のための姿勢・ポール弾性特性活用戦略

学位の種別: 課程博士審査委員会委員 : (主査)東京大学教授 國吉 康夫, 東京大学教授 中村 仁彦, 東京大学教授 稲葉 雅幸, 東京大学教授 原田 達也, 東京大学講師 新山 龍馬University of Tokyo(東京大学