Lack of inhibition of carrot colchicine binding activity by podophyllotoxin

AbstractThe binding of [3H]colchicine to carrot cell extract was not inhibited by an excess amount of podophyllotoxin. Under the same experimental condition, porcine brain tubulin almost completely lost its [3H]colchicine binding activity. The components in the carrot cell extract did not affect the interaction of brain tubulin and podophyllotoxin

Japanese Resident Physicians' Attitudes, knowledge, and Perceived Barriers on the Practice of Evidence Based Medicine: a Survey

<p>Abstract</p> <p>Background</p> <p>Evidence based medicine plays a crucial role as a tool that helps integrate research evidence into clinical practice. However, few reports have yet to examine its application in daily practice among resident physicians in Japan. The aim of this study was to assess the attitudes towards and knowledge of EBM among resident physicians in Japanese and determine perceived barriers to its use.</p> <p>Findings</p> <p>A cross-sectional, self-administered anonymous questionnaire was distributed to 60 resident staffs at Saga University Hospital in Japan.</p> <p>Forty residents completed and returned the questionnaire. Fifty four percent of respondents understood the basic terminology of EBM, 3% could explain this to others, and 41% indicated they would like to understand the terminology more. Thirteen percent admitted having a good understanding of EBM basic skills. Fifty respondents indicated having read EBM sources, but only 3% indicated that they use these sources in clinical decision making. The most prominent barriers of EBM application revealed in this study were insufficient time to access the sources, a lack of native language references, and insufficient basic EBM skills, but not scepticism about the EBM concept.</p> <p>Conclusions</p> <p>In general, respondents positively welcomed EBM, and moderately understood and knew basic EBM skill; however, barriers in its application were shown to exist.</p

Characterization of coronary calcified plaque by using multimodality intravascular imaging

Regular Articlejournal articl

Curriculum Development to Promote the Ability to Live in Society-Social and Vocational Independence through a Special Support Class at Junior High School

グロール化が一層進行するこれからの社会において，将来の就労を含む生活に向けた生活力の育成を目指し，教科「職業・家庭」に新たに社会生活に関する内容を加味した，教科「キャリアマネジメント」を教育課程に位置づけ，カリキュラム開発を行っている。評価の４観とキャリア教育における４つの基礎的・汎用的能力を用いた評価によって生徒の変容を見取り授業評価を行うことで，カリキュラムについて検討した結果，生徒や保護者，教員に対して一定の効果があった。今後は，学習過程とそれによって身につく資質・能力について整理することが課題である。With the ongoing globalization in society, it is necessary to develop a new type of curriculum to prepare today's students for their future lives, especially their careers. TI1e curriculum developed in this study places an emphasis on vocation and home life, and it includes a new subject-Career Management-which deals with social life. The lessons in each unit for this subject were evaluated using reference criteria and in terms of four career abilities. From these results, adjustments were made to the lesson content, and the effect of the new curriculum was measured. The curriculum was found to be effective for students, their parents, and teachers. It will be necessary in a future study to examine ways of developing the associated learning process and assess its effects with regard to promoting competencies