Sesquiterpene constituents from the soft coral <i>Sinularia nanolobata</i>

<p>Using various chromatographic separations, four sesquiterpenes (<b>1</b>–<b>4</b>), including two new compounds, nanolobatols A and B (<b>1</b> and <b>2</b>), were isolated from the Vietnamese soft coral <i>Sinularia nanolobata</i>. Their structures were determined on the basis of spectroscopic data (¹H and ¹³C NMR, HSQC, HMBC, ¹H–¹H COSY, NOESY and FT-ICR-MS) and by comparison with the literature values. The cytotoxic activity of isolated compounds against a panel of eight human cancer cell lines was also evaluated.</p

Steroid constituents from the soft coral <i>Sinularia microspiculata</i>

<p>A methanol extract of the soft coral <i>Sinularia microspiculata</i> revealed five sterols, including two new compounds. Using combined chromatographic and spectroscopic experiments, the new compounds were found to be 7-oxogorgosterol (<b>1</b>) and 16α-hydroxysarcosterol (<b>2</b>). Their structures were determined on the basis of spectroscopic data (¹H and ¹³C NMR, HSQC, HMBC, ¹H-¹H COSY, NOESY, and FT-ICR-MS) and by comparing obtained results to the values indicated in previous studies. Among the isolated compounds, <b>3</b> showed weak cytotoxic effects against HL-60 (IC₅₀ =  89.02  ±  9.93 μM) cell line, whereas <b>5</b> was weakly active against HL-60 (IC₅₀ =  82.80  ±  13.65 μM) and SK-Mel2 (IC₅₀ =  72.32  ±  1.30 μM) cell lines.</p

Eudesmane and aromadendrane sesquiterpenoids from the Vietnamese soft coral <i>Sinularia erecta</i>

<p>Using various chromatographic separations, eight sesquiterpenoids (<b>1</b>–<b>8</b>), including one new compound 3<i>β</i>,5<i>α</i>-dihydroxyeudesma-4(15),11-diene (<b>1</b>), were isolated from the MeOH extract of the Vietnamese soft coral <i>Sinularia erecta</i>. The structure elucidation was confirmed by spectroscopic experiments including 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities against three human cancer cell lines (A-549, HeLa and PANC-1) of all isolated compounds were evaluated by MTT-based colorimetric assays. Compound <b>1</b> exhibited selective cytotoxicity against the A549 cell line with IC₅₀ of 14.79 ± 0.91 μM.</p