2 research outputs found
Magnetofluorescent Carbon Quantum Dot Decorated Multiwalled Carbon Nanotubes for Dual-Modal Targeted Imaging in Chemo-Photothermal Synergistic Therapy
Magnetofluorescent
nanoparticles with diagnostic and therapeutic
functions show great promise in nanomedicine. Here, we report the
magnetofluorescent carbon nanotubes (CNTs)/doxorubicin (DOX) nanocomposites
and their functions act in synergetic chemo-photothermal synergistic
therapy (Chemo/PTT) in cancer excision. Magnetofluorescent CNTs conjugated
with a folic acid (FA-GdN@CQDs-MWCNTs) were targets for dual-modal
fluorescence (FL)/magnetic resonance (MR) imaging. Experiments in
vitro and in vivo identified FA-GdN@CQDs-MWCNTs with low toxicity,
and good biocompatibility. Moreover, FA-GdN@CQDs-MWCNTs whose release
can be fostered by pH and NIR light dual-stimuli had been proved to
be available for loading DOX. Following nuclear translocations, FA-GdN@CQDs-MWCNTs
were engineered to deliver DOX that targeted the nuclei. In vivo experiment
indicates that the Chemo/PTT, as compared with the respective single
treatment, can significantly control tumor growth. In addition, Chemo/PTT
was not shown to render any appreciable toxicity. These findings suggest
that the FA-GdN@CQDs-MWCNTs/DOX could function as a multifunctional
platform for simultaneous FL/MR imaging, PTT therapy, and drug delivery
One-Stop Integrated Nanoagent for Bacterial Biofilm Eradication and Wound Disinfection
To
meet the requirements of biomedical applications in the antibacterial
realm, it is of great importance to explore nano-antibiotics for wound
disinfection that can prevent the development of drug resistance and
possess outstanding biocompatibility. Therefore, we attempted to synthesize
an atomically dispersed ion (Fe) on phenolic carbon quantum dots (CQDs)
combined with an organic photothermal agent (PTA) (Fe@SAC CQDs/PTA)
via a hydrothermal/ultrasound method. Fe@SAC CQDs adequately exerted
peroxidase-like activity while the PTA presented excellent photothermal
conversion capability, which provided enormous potential in antibacterial
applications. Based on our work, Fe@SAC CQDs/PTA exhibited excellent
eradication of Escherichia coli (>99% inactivation
efficiency) and Staphylococcus aureus (>99% inactivation
efficiency) based on synergistic chemodynamic therapy (CDT) and photothermal
therapy (PTT). Moreover, in vitro experiments demonstrated
that Fe@SAC CQDs/PTA could inhibit microbial growth and promote bacterial
biofilm destruction. In vivo experiments suggested
that Fe@SAC CQDs/PTA-mediated synergistic CDT and PTT exhibited great
promotion to wound disinfection and recovery effects. This work indicated
that Fe@SAC CQDs/PTA could serve as a broad-spectrum antimicrobial
nano-antibiotic, which was simultaneously beneficial for bacterial
biofilm eradication, wound disinfection, and wound healing