Flow chart of literature search and study selection.

<p>Flow chart of literature search and study selection.</p

Results of meta-analysis for OPA1 polymorphisms and risk of primary open angle glaucoma.

<p>Results of meta-analysis for OPA1 polymorphisms and risk of primary open angle glaucoma.</p

Forest plots describing overall meta-analysis (left) and cumulative meta-analysis (right) of the associations between IVS+32 C>T polymorphism and POAG risk.

<p>Odds ratios shown for individual studies for allelic model genotype contrasts (T vs. C). Cumulative odds ratios shown for each additional information step obtained by stepwise inclusion of every new study into pooled estimate. A. meta-analysis of association between IVS+32 C>T variant and NTG in order of sample size. B. meta-analysis of association between IVS+32 C>T variant and HTG in order of sample size.</p

Forest plots describing subgroup analyses of the association between OPA1 polymorphisms and risk for HTG.

<p>The size of the square indicate the relative weight of each study.Bars,95% confidence interval(95% CI) A. subgroup analysis of IVS8+4 C>T stratified by ethnicity in order of publication year;B subgroup analysis of IVS8+32 T>C stratified by ethnicity in order of publication year.</p

Forest plots describing overall meta-analysis (left) and cumulative meta-analysis (right) of the associations between IVS+4 T>C polymorphism and POAG risk.

<p>Odds ratios shown for individual studies for allelic model genotype contrasts (C vs. T). Cumulative odds ratios shown for each additional information step obtained by stepwise inclusion of every new study into pooled estimate. A. meta-analysis of association between IVS+4 T>C variant and NTG in order of sample size; B. meta-analysis of association between IVS+4 T>C variant and HTG in order of sample size.</p

Begg’s funnel plot of OPA1 polymorphisms and NTG for allelic model.

<p>A: IVS8+4 T vs C; B:IVS8+32 C vs T. Each circle represents a separate study for the indicated association, and its size is proportional to the sample size of each study.</p