1 research outputs found
A One-Pot Assembly of Fully Substituted Alkyl 5‑Aminothiophene-2-carboxylates from Allenes, Isothiocyanates, and Alkyl 2‑Bromoacetates
A novel simple approach
to highly functionalized multisubstituted
thiophenes such as alkyl 4-alkoxy-5-amino-3-methylthiophene-2-carboxylates
through the one-pot sequential reaction of α-lithiated alkoxyallenes
with isothiocyanates and alkyl 2-bromoacetates has been discovered.
The process proceeds quickly (30–45 min) via in situ formation
and intramolecular cyclization of alkyl 2-[(2-alkoxybuta-2,3-dienimidoyl)Âsulfanyl]Âacetates
(1-aza-1,3,4-trienes)