INFLUENCE OF ALUMINIUM ON T HE CONCENTRATION OF PHOSPHORUS AND ADENYL NUCLEOTIDES IN WHITE RAT ERYTHROCYTES

The experiment covered 126 white male rats divided into two groups: 70 poisoned rats (group one) and 56 control ones (group two). Animals from the first group were perorally introduced I per cent of water solution of AlCl3 in a dosis of 3 mg Al3+/kg body mass daily for 40 days. The concentrations of inorganic phosphorus and adenyl nucleotides such as AMP, ADP and ATP in rat erythrocytes were determined on the 5th, 10th, 15th, 20th, 30th, and 40th day of trial. An elevation of ATP concentration tending towards a shift to the left of ATP/ADP balance during the second half of the experiment was established. Inorganic phosphorus reduced significantly during the whole trial. These alterations testify to disturbed processes of erythrocytic energy Metabolism

CHANGES IN FREE ADENOSINE TRI-, DI AND MONOPHOSPHATE CONCENTRATIONS IN THE BRAIN OF WHITE RATS, FED NORMAL AND RICH IN PROTEINS DIETS IN EXPERIMENTAL MANGANESE TREATMENT

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BIOCHEMICAL PARAMETERS OF WORKERS EXPOSED TO MANGANESE

The study covered 34 workers from a manganese mine (group one) and 33 workers from a flux manufacture (group two). The following parameters were examined: total protein, protein fractions, immunoglobulins A, M, and G, total cholesterol, the enzyme activity of ASAT, ALAT, GLDH, LDH, and CE in the serum, as well as manganese in the blood by using the method of atomic absorption spectrophotometry. Blood manganese concentration was reliably elevated. There was reduction of total protein and albumin contents while alpha 2-globulins were enhanced for the second group only. The immunoglobulin A was increased which was more outlined for the group two whilst the total cholesterol increase was more manifested for the group one. All the enzymes were significantly activated. The necessity for dynamic follow-up of the parameters examined during the evaluation of the health risk and monitoring the health status of workers from manganese-dangerous projects was emphasized

Innovative construction and the role of boundary objects: a Gehry case study

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Physical objects have long been used in addressing the challenges involved in constructing innovative buildings, yet their significance for collaborative problem solving in inter-organizational projects is rarely acknowledged. The aim of this research is to investigate what happens when a project team has to collaboratively innovate to address radical design challenges in a construction setting. We focus on the role of a full-scale mock-up of a façade in transforming the design intent for a building by Frank Gehry into design realization. The concept of boundary objects is used as an analytical lens via a case study methodology utilizing non-participant observation of weekly meetings and workshops over a period of 10 months covering client, consultant and contractor involvement. The research shows the role of mock-ups in radical construction settings is in tension along three delivery dimensions: performance, aesthetic and technical construction. Task completion competed with the requirements for experimentation around innovative problem solving with the how to construct it problem left unresolved. The findings suggest that co-location and synchronicity are critical conditions for collaborative and innovative problem solving in radical construction contexts. Project teams need to create open-ended ‘moments’ for iterating critical objects and the interactions that take place around them

STUDY OF THE NUTRITION OF CHILDREN AGED 6 YEARS IN CONDITIONS OF SEMIBOARDING-SCHOOL OF EDUCATION

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BIOLOGICAL PROPHYLAXIS OF OCCUPATIONAL EXPOSURE TO LEAD

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Which rating system is better – qSOFA or SIRS?

IntroductionThe definitions of sepsis and septic shock were redefined in 2016. This study compares the performance of qSOFA with that of SIRS criteria for the diagnosis of sepsis and prediction of 30-day mortality.AimThe aim of this article is to assess the severity of the infection of patients using SIRS and qSOFA scales and to compare their specificity and predictive value. Materials and MethodsA prospective, non-interventional single-center clinical trial was conducted at St. Marina University Hospital in Varna. The sample included 87 patients with sepsis and septic shock. The criteria for inclusion in the study were laboratory constellation for systemic exposure; over 18 years of age; with or without co-morbidities; no malignancies. Pregnancy, neoplasia and the age of under 18 were the criteria for exclusion. Logistic regression was used to test the predictability of both scales. ROC curve analysis determined the sensitivity and specificity of SIRS and qSOFA.ResultsOur analysis showed that both SIRS and qSOFA are significant predictors of mortality of septic patients. The SIRS scale had a 2.050-fold probability of predicting the death of the patient (p = 0.004, 95% CI 1.255 - 3.349), whereas the qSOFA score was 2.581 times more likely to predict mortality in patients with sepsis and septic shock (p = 0.0001, 95% CI 1.557 - 4.279). Cut-off values for SIRS higher than 2.5 points showed 91% sensitivity and  60% specificity - (AUC 0.80, 95% CI - 0.712 - 0.907), whereas qSOFA scores greater than 1.5 points indicated sensitivity of 82.2% and  specificity of 70.3% (AUC 0.85, 95% CI 0 0.770 - 0.934).Conclusion SIRS and qSOFA criteria for early detection of sepsis are useful clinical tools for mortality reduction and predictability. 

Half-quadratic regularization for MRI image restoration

We consider the reconstruction of MRI images by minimizing regularized cost-functions. To accelerate the computation of the estimate, two forms of half-quadratic regularization, multiplicative and additive, are often used. In Nikolova and Ng (2002), we have compared both theoretically and experimentally the efficiency of these two forms using one-dimensional signals. The goal of this paper is to compare experimentally the efficiency of these two forms using MRI image reconstruction. We find that using the additive form is more computationally effective than using the multiplicative form.published_or_final_versio

EXPERIMENTAL INVESTIGATION OF THE EFFECT OF PERORALLY APPLIED ALUMINIUM ON THE STRUCTURE AND FUNCTION OF SOME INTERNAL ORGANS. LUNG ALTERATIONS IN RATS

The authors examined the lung lesions caused by peroral aluminium application as a 0,1 % solution of AlСl3 in a dose of 3 mg Al3+/kg b. w. for 40 days in a total of 126 white male rats (70 experimental and 56 control). Visible structural alterations were established on the 15th day of the trial consisting in desquamation of bronchial epithelium, enhanced pmounts of acid glucosaminoglycans in the cell cytoplasm and irregular disposition of cells. Later on, the activity of SDH, alkaline phosphatase, and ATP-ase decreased but acid phosphatase activity increased. Connective-tissue fibres grew up in the wall of some bronchi. These morphological findings suggest that although perorally accepted, AlСl3 induced structural lesions in the lungs as well as metabolic disturbances in the bronchial mucosa which depended on the duration of treatment