Significant group differences (p < 0.05, corrected) in the white matter revealed by tract-based spatial statistics.

<p>A) without flipping, B) after flipping to the left and C) to the right side. Color code: red = increased, blue = decreased diffusion parameters in the Parkinson patients compared to the healthy subjects; green = skeleton of the white matter tracts. AD = axial, MD = mean and RD = radial diffusion. MNI coordinates of the voxel showing the highest significance is provided on the figure.</p

Demographic data and cognitive scores.

<p>Demographic data and cognitive scores.</p

Focal decrease of the gray matter density in the Parkinson’s patients revealed by voxel-based-morphometry.

<p>The localization was the same in the comparisons with (flipped to the left side: p<0.014 and to the right: p<0.02, corrected) and without flipping (p<0.059). MNI coordinates of the voxel showing the highest significance is provided on the figure.</p

Connectivity of the thalamic lesion of the essential tremor patient, evaluated using multi-fiber probabilistic tractography.

<p>The tracts reach the primary motor cortex, on one hand, and travelling to the cerebellum on the other hand. The image is thresholded at 250 particles (5%).</p

Connectivity of the thalamic lesion, evaluated using multi-fiber probabilistic tractography.

<p>The tracts reach the premotor cortex, on one hand, and the nucleus ruber and the perirubral mesencephalon, on the other hand, with some travelling further to the cerebellum. The image is thresholded at 500 particles (10%).</p

Connectivity-based segmentation of the left thalamus of the patient having essential tremor.

<p>Results are overlaid on the postoperative T1-weighted image. White voxels represent the location of the Stereotactic lesion. The colour coding of the thalamic segmentation is the same as that using in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029969#pone-0029969-g003" target="_blank">Figure 3</a>. The lesion is in the area of the thalamus connected most strongly to the primary motor cortex: the putative Vim.</p

Preoperative FLAIR images show the right perirubral mesencephalic traumatic haemorrhage.

<p>Images are presented in radiological convention.</p

Spatial localisation of peak Vop and Vim voxels as defined by probabilistic tractography.

<p>Individual images were realigned to standard space with a 6 DOF transformation in a way to match the location of the AC and align the AC-PC line and the midsagittal plane. The registered peak connectivity voxels for the primary motor (Vim - in red) and for the premotor cortex (Vop – in blue) are shown on three orthogonal slices.</p