Regression models: Association of high clinical threshold [9] levels of serum IgG to selected periodontal species and incident AD.

<p>Model 1: bivariate association with single periodontal antibody.</p><p>Model 2: controlled for age at phlebotomy (baseline).</p><p>Model 3: Model 2, also controlled for APOE status, gender, and education.</p><p>Model 4: Model 3, also controlled for hypertension, smoking, stroke, and diabetes mellitus.</p><p>*Models shown using pseudolikelihood estimator, robust variance estimator, and weight of cases (1), controls (10) [most conservative method].</p><p>Models highlighted in bold indicate p<0.05. HR: Hazard ratio.</p><p>Regression models: Association of high clinical threshold <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114959#pone.0114959-Dye2" target="_blank">[9]</a> levels of serum IgG to selected periodontal species and incident AD.</p

Distribution of serum IgG antibody levels to selected periodontal species.

<p>*Thresholds are drawn from a study of NHANES-III subjects <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114959#pone.0114959-Dye2" target="_blank">[9]</a>; above each individual periodontal pathogen level, the accuracy of a serology-based diagnostic test to detect moderate-severe periodontitis according to the CDC/AAP definition is maximized. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114959#pone.0114959-Page1" target="_blank">[30]</a>.</p><p>Distribution of serum IgG antibody levels to selected periodontal species.</p

Regression models: Association of high levels (80^th percentile) of serum IgG to selected periodontal species and incident AD.

<p>Model 1: bivariate association with single periodontal antibody.</p><p>Model 2: controlled for age at phlebotomy (baseline).</p><p>Model 3: Model 2, also controlled for APOE status, gender, and education.</p><p>Model 4: Model 3, also controlled for hypertension, smoking, stroke, and diabetes.</p><p>*Models shown using pseudolikelihood estimator, robust variance estimator, and weight of cases (1), controls (10) [most conservative method]; HR: Hazard ratio.</p><p>Regression models: Association of high levels (80^th percentile) of serum IgG to selected periodontal species and incident AD.</p

Characteristics of the study cohort.

<p>P-values based on t-test for continuous variables, and on chi-square for categorical variables.</p><p>*Case-cohort study v. complete WHICAP cohort.</p><p>**Cases v. controls within the case-cohort study.</p><p>Characteristics of the study cohort.</p

Results from logistic regression analysis that evaluated the association between the Mediterranean dietary score and dementia.

<p>Results from logistic regression analysis that evaluated the association between the Mediterranean dietary score and dementia.</p

Individual components of the Mediterranean dietary pattern by cognitive status and their association with cognitive status and cognitive performance.

<p>Individual components of the Mediterranean dietary pattern by cognitive status and their association with cognitive status and cognitive performance.</p

Demographic, anthropometric, medical characteristics and dietary intake of the study participants by cognitive status.

<p>Demographic, anthropometric, medical characteristics and dietary intake of the study participants by cognitive status.</p

Results from multiple linear regression analysis that evaluated the association between the Mediterranean dietary score and z scores of cognitive performance.

<p>Results from multiple linear regression analysis that evaluated the association between the Mediterranean dietary score and z scores of cognitive performance.</p

Demographic, anthropometric, medical characteristics, dietary intake and cognitive status of the study participants by quartiles of the Mediterranean dietary score.

<p>Demographic, anthropometric, medical characteristics, dietary intake and cognitive status of the study participants by quartiles of the Mediterranean dietary score.</p

Longitudinal variation with age for the Mini-Mental State Examination (MMSE) and cognitive domains.

<p>Results were calculated from pooled estimates of the fixed effects of age and age², adjusted for sex and education. Dashed lines indicate 95% confidence bands.</p