2 research outputs found
The Usefulness of Myeloperoxidase in Prediction of In-Hospital Mortality in Patients with ST-Segment Elevation Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention
Background: The predictive value of myeloperoxidase (MPO) in ST-segment elevation myocardial infarction (STEM I) treated by primary percutaneous coronary intervention (PCI) has not been established. The aim of the present study was to investigate MPO as a predictor of in-hospital mortality in STEMI patients treated by primary PCI. Methods: Study population consisted of 189 STEMI patients having undergone primary PCI. Plasma MPO level was measured 24 hours after symptom onset using chemiluminescent microparticle immunoassay (Abbott Diagnostics, Germany). The Receiver Operating Characteristic analysis was performed to identify the most useful MPO cut-off level for the prediction of in-hospital mortality. The patients were divided into two groups according to the cut-off MPO level: high MPO group (>= 840 pmol/L, n = 65) and low M PO group ( lt 840 pmol/L, n = 124). Results: The high M PO group had significantly more frequent anterior wall infarctions (p lt 0.001) and Killip class >1 on admission (p=0.013) as well as lower left ventricular ejection fraction (LVEF) (p=0.011) and higher B-type natriuretic peptide (BNP) (p=0.029) than the low MPO group. The incidence of in-hospital mortality was 5.8% and was significantly higher in the high M PO group (13.8%) than in the low MPO group (1.6%) (p=0.001). Multiple logistic regression analysis identified the plasma MPO level as an independent predictor of in-hospital mortality (OR 3.88, 95%CI 1.13 - 13.34, p=0.031). Conclusions: Plasma M PO level independently predicts in-hospital mortality in STEMI patients treated by primary PCI. (Clin. Lab. 2012;58:125-131
Influence of manual thrombus aspiration on left ventricular diastolic function in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention
Introduction. Data on effects of thrombus aspiration on left ventricular
diastolic function in ST-elevation myocardial infarction (STEMI) population
are scarce. Objective. We sought to compare echocardiographic indices of the
diastolic function and outcomes in STEMI patients treated with and without
manual thrombus aspiration, in an academic, high-volume percutaneous coronary
intervention (PCI) center. Methods. A total of 433 consecutive patients who
underwent primary PCI in 2011-2012 were enrolled in the study. Patients were
not eligible for the study if they already suffered a myocardial infarction,
had been previously revascularized, received thrombolytics, presented with
cardiogenic shock, had significant valvular disease, atrial fibrillation or
had previously implanted pacemaker. Comprehensive echocardiogram was
performed within 48 hours. During follow-up patientsā status was assessed by
an office visit or telephone interview. Results. Patients treated with
thrombus aspiration (TA+, n=216) had similar baseline characteristics as
those without thrombus aspiration (TA-, n=217). Groups had similar total
ischemic time (319 Ā± 276 vs. 333Ā±372 min; p=0.665), but TA+ group had higher
maximum values of troponin I (39.5 Ā± 30.5 vs. 27.6 Ā± 26.9 ng/ml; p<0.001).
The echocardiography revealed similar left ventricular volumes and systolic
function, but TA+ group had significantly higher incidence of E/eā>15, as a
marker of severe diastolic dysfunction (TA+ 23.1% vs. TA- 15.2%; p=0.050).
During average follow-up of 14Š}5 months, major adverse cardiac/ cerebral
events occurred at the similar rate (log rank p=0.867). Conclusion. Thrombus
aspiration is associated with a greater incidence of severe diastolic
dysfunction in unselected STEMI patients treated with primary PCI, but it
doesnāt influence the incidence of major adverse cardiovascular events.
[Projekat Ministarstva nauke Republike Srbije, br. 175099