3 research outputs found
Windowless microfluidic platform based on capillary burst valves for high intensity x-ray measurements
A High Mobility Reactor Unit for R&D Continuous Flow Transfer Hydrogenations
A suitcase sized mobile reactor unit
(MRU) weighing in at less
than 10 kg was designed for laboratory scale transfer hydrogenations
in continuous flow. Simple cyclohexene and a cosolvent in combination
with a palladium-on-charcoal packed bed reactor provided a setup with
isolation of nearly all products without the need for further purification.
Several functional groups including olefins, triple bonds, nitro-groups,
carbonyls, and so forth were effectively reduced with retention times
as low as 2 min. Additionally, standard protection groups such as
Cbz, benzyl, and allyl ether or esters were removed in high yields.
To prove the flexibility of the setup an example of the Mizoroki–Heck
reaction was also performed on the MRU. Finally, two scale-up transfer
hydrogenation experiments were performed affording isolation of the
desired target compounds in 0.5 and 0.8 mol scales with less than
4 h of continuous operation on the MRU