Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review

Evidence from different screening programs indicated that the rate of congenital hypothyroidism (CH) was higher in pre-term and low-birth-weight (LBW) newborns than normal ones. Incomplete development of hypothalamic–pituitary axis in this group of neonates results in the delayed rise of TSH and missing cases with CH. Hence, there is a great need for a practicable systematic screening method for proper diagnosis of CH in this group of neonates. In this review, we systematically reviewed papers with the following key words ([Congenital Hypothyroidism AND Screening AND Thyroxine AND Thyroid Stimulating Hormone AND Low Birth Weight AND Premature]) in international electronic databases including PubMed, Scopus, and Google Scholar. After quality assessment of selected documents, data of finally included papers were extracted. In this review, 1452 papers (PubMed: 617; Scopus: 714; Google scholar: 121) were identified through electronic database search. One hundred and ninety four articles were assessed for eligibility, from which 36 qualified articles were selected for final evaluation. From the reviewed articles, 38.9%, 11.11% and 8.3% recommended rescreening in this group of neonates, lowering the screening cutoff of TSH and using cutoffs according to the gestational age, respectively. Some of them (13.9%) recommended using both TSH and T4 for screening of preterm infants. After reviewing available data, we recommend repeating the screening test in pre-term, LBW and very-low- birth-weight (VLBW) infants at age of two, six and ten weeks by measuring TSH and FT4 levels simultaneously and considering TSH = 10 mU/L as the cutoff level for positive and suspicious cases

Revealing the effect of an industrial flash flood on vegetation area: A case study of Khusheh Mehr in Maragheh-Bonab Plain, Iran

Floods are one of the most significant environmental hazards that can have harmful effects on agricultural activities and vegetation. The primary objective of this study is to analyze the de- structive after-effects of an industrial flash flood on the vegetation of the Khusheh Mehr region. This flash flood occurred due to a break in the wastewater ponds of the Kaveh Soda factory on April 25, 2010. Using the Normalized Difference Water Index (NDWI) and the Normalized Differ- ence Vegetation Index (NDVI) derived from time-series Landsat data over the period of 2000–2020, we analyzed the changes in wastewater ponds and regional vegetation before and af- ter the wastewater flood occurred. We also investigate the quantitative and qualitative changes in vegetation during the past 20 years and detect the flood passage through this area. The results show that 538 ha out of the total 2123 ha of Khusheh Mehr were directly affected by the runoff resulting from the 2010 flood, and 1250000 m3 of industrial wastewater was discharged in the study area. The analysis of the vegetation in 2010 showed that during May and July, the effi- ciency and expansion of vegetation in these areas (NDVI >0.3) decreased by 90% and 55%, re- spectively, compared to the same periods in 2009 and 2006. The study is significant because it can help evaluate the effects of the flash flood not only on wastewater ponds and vegetation but also on the contamination of underground and surface waters as chemicals and industrial waste- water held in natural and artificial environments are discharged during a flood and directly affect vegetation. The findings can provide useful information for hazard and land use management and support policymakers, e.g., payment for financial loss of farmers