Evaluation des difficultés psychosociales des personnes VIH au sein d’une consultation infirmière [Evaluation of psychosocial difficulties and needs of persons living with HIV in a nurse consultation]

Malgré les progrès effectués dans le domaine des traitements antirétroviraux, la prise en charge psychosociale des patients vivant avec le VIH reste complexe et nécessite une approche multidisciplinaire. Une échelle d’auto-évaluation des difficultés et besoins d’aides psychosociaux a été utilisée par une équipe d’infirmières travaillant dans une consultation ambulatoire VIH. Après 3 ans d’expérience, cet outil, très bien accepté par les patients, a permis de révéler une prévalence importante de difficultés psychosociales dans cette population, touchant notamment la santé psychique, la situation financière et la sexualité. Cet outil a permis en outre de mettre en place un certain nombre d’interventions infirmières ciblées pour améliorer la prise en charge des patients. [Despite the improvements in antiretroviral therapy, the psychosocial management of persons living with HIV remains complex and requires a multidisciplinary approach. An auto-evaluation scale of psychosocial difficulties and needs was used by a team of nurses working in an HIV outpatient clinic. After 3 years of experience, this well-accepted tool revealed a high prevalence of psychosocial difficulties within this population, including psychological health, financial situation and sexual life. This instrument also allowed implementing a number of targeted nurse interventions to improve the management of these patients.

Transnational Governance of Workers' Rights: Outlining a Research Agenda

In twentieth century Europe and the USA, industrial relations, labour, and workers’ rights issues have been handled through collective bargaining and industrial agreements between firms and unions, with varying degrees of government intervention from country to country. This industrial relations landscape is currently undergoing fundamental change with the emergence of transnational industrial relations systems that complement existing national industrial relations systems. Despite the significance of this ongoing change, existing research has only started to explore the implications of this change for how workers’ rights are governed around the globe. This paper addresses this gap by outlining an agenda for future research into the transnational governance of workers’ rights. Fulfilling such a research agenda would be both challenging, as it requires combining the so far divergent industrial relations and business ethics research streams, and rewarding, as it provides ample scope for promising future research

TNC Motives for Signing International Framework Agreements: A Continuous Bargaining Model of Stakeholder Pressure

code of conduct, corporate social responsibility, international framework agreement, labour practice, non-governmental organisation, stakeholder, transnational corporation, union,

De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis

We previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an additional 291 TD trios and analyze the combined set of 802 trios. We observe an overrepresentation of de novo damaging variants in simplex, but not multiplex, families; we identify a high-confidence TD risk gene, CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3); we find that the genes mutated in TD patients are enriched for those related to cell polarity, suggesting a common pathway underlying pathobiology; and we confirm a statistically significant excess of de novo copy number variants in TD. Finally, we identify significant overlap of de novo sequence variants between TD and obsessive-compulsive disorder and de novo copy number variants between TD and autism spectrum disorder, consistent with shared genetic risk. [Display omitted] •Recurrent de novo variants identify a new high-confidence TD risk gene: CELSR3•Genes involved in cell polarity are more likely to be disrupted by de novo variants•De novo sequence variants may carry more risk in simplex families, female probands•De novo CNVs occur 2 to 3 times more often in TD probands than in matched controls Wang et al. expand their earlier exome-sequencing work in TD, adding 291 trios and conducting combined analyses suggesting de novo variants carry more risk in individuals with unaffected parents, establishing de novo structural variants as risk factors, identifying CELSR3 as a risk gene, and implicating cell polarity in pathogenesis