Understanding System Complexity in the Non-Destructive Testing of Advanced Composite Products

Non-destructive testing (NDT) is a quality control measure designed to ensure the safety of products according to established variability thresholds. With the development of advanced technologies and a lack of formalised knowledge of the state-of-the-art, the National Composites Centre, Bristol, has identified that the increasing complexity of composite products will lead to some severe inspection challenges. To address the apparent knowledge gap and understand system complexity, a formulaic approach to introduce intelligence and improve the robustness of NDT operations is presented. The systemic development of a high-fidelity knowledge base (KB) involves the establishment of a capability matrix that maps material, component, and defect configuration to the capabilities and limitations of selected detection methods. Population and validation are demonstrated through the experimental testing of reference standards and evaluated against an assessment criteria. System complexity in ultrasonic testing operations focusses on capturing the inherent risks in inspection and the designation of evidence-based path plans for automation platforms. Anticipated deployment of the validated applicability data within the KB will allow for road-mapping of the inspection technique development and will provide opportunities for knowledge-based decision making. Moreover, the KB highlights the need for Design for Inspection, providing measurable data that the methodology should not be ignored

Neonatal central diabetes insipidus in a case of hydranencephaly

Neonatal diabetes insipidus (DI) poses both diagnostic and therapeutic challenge to the neonatologists. Neonatal central DI (CDI) is an uncommon disorder which is characterized by polyuria, hypernatremia, high plasma osmolality, and low urine osmolality. Our full-term neonate with an antenatal magnetic resonance imaging showing hydranencephaly presented to us on day 4, with persistent hypernatremic dehydration along with the polyuria which was not getting corrected by the routine management of hypernatremic dehydration. Further investigations revealed urine hypo-osmolality and high serum osmolality and a good response to oral desmopressin (DDAVP). This helped to diagnose CDI secondary to hydranencephaly. The baby was discharged on oral DDAVP, but unfortunately, the baby succumbed at 3 months of age

Supporting community-based mental health initiatives: insights from a multi-country programme and recommendations for funders.

Community-based mental health initiatives are uniquely positioned to understand the mental health needs of their local population and provide relevant, culturally appropriate and sustainable responses. However, at the grassroots level, mental health initiatives in low- and middle-income countries face key challenges, such as inadequate funding, barriers to demonstrating impact and difficulty engaging with stakeholders. The Ember Mental Health programme establishes 12-month partnerships with community-based mental health initiatives in low- and middle-income countries to support them to address these challenges, grow and achieve sustainability. This paper outlines a longitudinal qualitative study conducted to evaluate the 2020-2021 Ember Mental Health programme. Data were collected from March 2020 to March 2021 through semistructured interviews conducted with 11 initiatives at various time points throughout their Ember Mental Health partnership. A framework approach was used to analyse all data in its original language. Findings indicated that initiatives particularly benefited from provision of side-by-side mentorship; opportunities for skills strengthening and strategic thinking; occasions to network with other like-minded initiatives and/or experts in global mental health; and support on team empowerment and well-being. Based on these findings, we put forward various recommendations for funders and other stakeholders working to support community-based mental health initiatives in low- and middle-income countries. Through establishing collaborative partnerships that challenge more top-down, traditional funder-grantee relationships, it is possible to support the rich ecosystem of initiatives working to address the mental health needs of communities

Probing the Black Hole Engine with Measurements of the Relativistic X-ray Reflection Component

Over the last decades X-ray spectroscopy has proven to be a powerful tool for the estimation of black hole spin and several other key parameters in dozens of AGN and black hole X-ray binaries. In this White Paper, we discuss the observational and theoretical challenges expected in the exploration, discovery, and study of astrophysical black holes in the next decade. We focus on the case of accreting black holes and their electromagnetic signatures, with particular emphasis on the measurement of the relativistic reflection component in their X-ray spectra.Comment: Astro 2020 Decadal science White Pape

Genomic Survey of E. coli From the Bladders of Women With and Without Lower Urinary Tract Symptoms

Urinary tract infections (UTIs) are one of the most common human bacterial infections. While UTIs are commonly associated with colonization by Escherichia coli, members of this species also have been found within the bladder of individuals with no lower urinary tract symptoms (no LUTS), also known as asymptomatic bacteriuria. Prior studies have found that both uropathogenic E. coli (UPEC) strains and E. coli isolates that are not associated with UTIs encode for virulence factors. Thus, the reason(s) why E. coli sometimes causes UTI-like symptoms remain(s) elusive. In this study, the genomes of 66 E. coli isolates from adult female bladders were sequenced. These isolates were collected from four cohorts, including women: (1) without lower urinary tract symptoms, (2) overactive bladder symptoms, (3) urgency urinary incontinence, and (4) a clinical diagnosis of UTI. Comparative genomic analyses were conducted, including core and accessory genome analyses, virulence and motility gene analyses, and antibiotic resistance prediction and testing. We found that the genomic content of these 66 E. coli isolates does not correspond with the participant’s symptom status. We thus looked beyond the E. coli genomes to the composition of the entire urobiome and found that the presence of E. coli alone was not sufficient to distinguish between the urobiomes of individuals with UTI and those with no LUTS. Because E. coli presence, abundance, and genomic content appear to be weak predictors of UTI status, we hypothesize that UTI symptoms associated with detection of E. coli are more likely the result of urobiome composition

Probing the Black Hole Engine with Measurements of the Relativistic X-ray Reflection Component

Over the last decades X-ray spectroscopy has proven to be a powerful tool for the estimation of black hole spin and several other key parameters in dozens of AGN and black hole X-ray binaries. In this White Paper, we discuss the observational and theoretical challenges expected in the exploration, discovery, and study of astrophysical black holes in the next decade. We focus on the case of accreting black holes and their electromagnetic signatures, with particular emphasis on the measurement of the relativistic reflection component in their X-ray spectra