Sensitivity analysis based dimension reduction of multiscale models

In this paper, the sensitivity analysis of a single scale model is employed in order to reduce the input dimensionality of the related multiscale model, in this way, improving the efficiency of its uncertainty estimation. The approach is illustrated with two examples: a reaction model and the standard Ornstein–Uhlenbeck process. Additionally, a counterexample shows that an uncertain input should not be excluded from uncertainty quantification without estimating the response sensitivity to this parameter. In particular, an analysis of the function defining the relation between single scale components is required to understand whether single scale sensitivity analysis can be used to reduce the dimensionality of the overall multiscale model input space

Managing the northern supply haul: legal aspect

Objective: to evaluate the regulatory legal mechanisms of the management of the Northern supply haul to the Far North regions and to formulate proposals for their improvement.Methods: a spatial approach that allowed us to consider the management of the Northern supply haul through the conceptualization of the spatial dimension of the remote areas supply processes – the predestination of a certain geographical coordinate system in which the object under study is placed, and the presence of regionalization determined by the spatial and temporal structuring of the territory of our country; interviewing and focus groups with executive authorities, representatives of research institutes, expert and business communities in order to form an array of initial data on the legal aspects of the Northern supply haul.Results: the article states that regional regulatory legal acts are predominantly non-systemic in nature (except in the Republic of Sakha (Yakutia)), regulating certain areas of state support, in particular the procedure for providing financial support. The low demand for other types of support is due to the need to form incentives for the participation of economic entities in the Northern supply haul under low business margins. The difficulty lies in the need to integrate centralized and decentralized supply systems in the absence of an appropriate legal framework.Scientific novelty: for the first time, an assessment of the effectiveness of state support measures for the Northern supply haul was carried out to determine the directions for improving its legal mechanisms. The definition of the Northern supply haul and categorization of these areas by periods of transport communication are proposed. The improvement of legal regulation based on the development of a single law with the definition of the rules for stakeholders is proposed.Practical significance: the presented assessment of the legal mechanisms of the Northern supply haul management and the formation of proposals for their improvement can be useful for correcting the existing and developing a new approach to the development of a specialized regulatory legal framework at both the federal and regional levels. The recommendations can be used by executive authorities in the development of state policy and regulatory regulation of life support issues in the northern territories

Белое движение в Сибири (1918–1923 гг.): рэферат к дипломной работе / Иван Антонович Квятковский; БГУ, Исторический факультет, Кафедра истории России, науч. рук. Кохнович В. А.

High proportion of children with MDR-TB had favourable outcome (90%) with early diagnosis and treatment initiation http://ow.ly/2eq5302gWm

Fluoroquinolone preventive therapy for children exposed to MDR-TB.

No Abstrac

Безопасность новых режимов профилактического лечения туберкулеза и приверженность к их соблюдению по данным Республики Казахстан

The objective: to assess the safety and compliance with new regimens for preventive treatment of drug susceptible and drug resistant tuberculosis.Subjects and Methods. The study was carried out in Almaty, the Republic of Kazakhstan; 182 patients from the groups facing the high risk of developing active tuberculosis received preventive tuberculosis treatment with new regimens: 71 patients were treated with isoniazid and rifampicin for 3 months (3 HR), 55 - with isoniazid and rifapentine for 1 month (1 HR), 56 - with levofloxacin for 6 months (6 Lfx).Results. During treatment with regimens 3 HR, 1 HP, 6 Lfx, no adverse events of severity degree 3-4 developed , while adverse events of severity degree 1-2 were rare and relieved. The patient-oriented approach to the organization of preventive chemotherapy made it possible to achieve high treatment completion rates: in the group receiving 3 HR, it was 97.2% of cases, in the group receiving 1 HP - 96.4%, and in the group receiving 6 Lfx - 82.2%.Цель исследования: оценка безопасности и приверженности к соблюдению новых режимов профилактического лечения лекарственно чувствительного и лекарственно устойчивого туберкулеза.Материалы и методы. Исследование выполнено в г. Алматы Республики Казахстан; новые режимы профилактического лечения туберкулеза получили 182 пациента из групп высокого риска развития активного туберкулеза: 71 – изониазид и рифампицин в течение 3 месяцев (3 HR), 55 – изониазид и рифапентин 1 месяц (1 НР), 56 – левофлоксацин 6 месяцев (6 Lfx).Результаты. При приеме режимов 3 HR, 1 HP, 6 Lfx нежелательных явлений 3-4 степени тяжести не наблюдалось, нежелательные явления 1-2 степени токсичности встречались редко и были купированы. Пациентоориентированный подход организации превентивной химиотерапии позволил достигнуть высоких показателей завершения лечения: в группе, получавшей 3 HR, в 97,2% случаев, 1 HP – в 96,4% и 6 Lfx – в 82,2%