fMRI BOLD activation for the contrast Cue for aversive stimulus > Cue for neutral stimulus.

<p>Statistical parametric maps (SPM) showing significant activations in the ventral striatum (A), the amygdala (C) and the insula (E). Colors indicate t-values of activated voxels and are coded in the bars on the right. Peak voxel beta values are shown for the two conditions in the ventral striatum (B), the amygdala (D) and the insular cortex (F). Family wise error corrected within bilateral ROIs at threshold <i>p</i> < 0.05, and Bonferroni corrected to control for tests of multiple ROIs.</p

Results of the psychophysiological interaction (PPI) analysis.

<p>(A) Statistical parametric map (SPM) showing the OFC voxel cluster that showed differences in interaction strength between the two conditions aversive and neutral. Colors indicate t-values of activated voxels and are coded in the bar on the right. Family wise error corrected within ROI at threshold <i>p</i> < 0.05 (B) The interaction found between the ventral striatum (VS) and the orbitofrontal cortex (OFC) is plotted with regression lines. The solid line represents aversive condition and the dashed line represents neutral condition. Beta values of the VS are indicated on the x-axis and beta values of the OFC are indicated on the y axis.</p