Quantum Computation in a radio single mode cavity: the dissipative Jaynes and Cummings Model

Our aim is to give an account, trough an analysis of a number of papers by F.Petruccione, H.J.Charmicael, J.C. Raimond and their contemporaries, of the specific answer that we gave to the problem of Open Quantum Systems dynamical evolution and how this idea evolves and develops in physical research and in the scientific debate of the following decades. Permanent solution should not been accepted from physical research, but analysis of the real work of scientists, of the difficulties they face and the ever changing solutions they offer is, we believe, part of our understanding of science and an indispensable basis for further methodological inquiries. In this paper we have chosen to analyze a dissipative Jaynes-Cummings model assuming the common electrodynamics free field for the bipartite system and an another independent bath for the cavity, so taking into account loosing of energy because of the imperfect mirrors. The Nud theorem application leads to predict new cooperative effects between the atom and the cavity mode as the creation of conditional transient entanglement, tending to become stationary as the coupling constant take a well defined value

Precision Medicine in Systemic Mastocytosis

Mastocytosis is a rare hematological neoplasm characterized by the proliferation of abnormal clonal mast cells (MCs) in different cutaneous and extracutaneous organs. Its diagnosis is based on well-defined major and minor criteria, including the pathognomonic dense infiltrate of MCs detected in bone marrow (BM), elevated serum tryptase level, abnormal MCs CD25 expression, and the identification of KIT D816V mutation. The World Health Organization (WHO) classification subdivides mastocytosis into a cutaneous form (CM) and five systemic variants (SM), namely indolent/smoldering (ISM/SSM) and advanced SM (AdvSM) including aggressive SM (ASM), SM associated to hematological neoplasms (SM-AHN), and mast cell leukemia (MCL). More than 80% of patients with SM carry a somatic point mutation of KIT at codon 816, which may be targeted by kinase inhibitors. The presence of additional somatic mutations detected by next generation sequencing analysis may impact prognosis and drive treatment strategy, which ranges from symptomatic drugs in indolent forms to kinase-inhibitors active on KIT. Allogeneic stem cell transplant (SCT) may be considered in selected SM cases. Here, we review the clinical, diagnostic, and therapeutic issues of SM, with special emphasis on the translational implications of SM genetics for a precision medicine approach in clinical practice

Inclusion of 2d transition metal dichalcogenides in perovskite inks and their influence on solar cell performance

Funding Information: Acknowledgments: V.N. wishes to thank the support from the ERC 3D2DPrint CoG Grant. The authors gratefully acknowledge the project Best4U—“Tecnologia per celle solari bifacciali ad alta Efficienza a 4 terminali per utility scale”. The authors are grateful to the “Progetto Tecnopolo per la Medicina di precisione, Deliberazione della Giunta Regionale n. 2117 del 21 November 2018”.Organic–inorganic hybrid perovskite materials have raised great interest in recent years due to their excellent optoelectronic properties, which promise stunning improvements in photovoltaic technologies. Moreover, two-dimensional layered materials such as graphene, its derivatives, and transition metal dichalcogenides have been extensively investigated for a wide range of electronic and optoelectronic applications and have recently shown a synergistic effect in combination with hybrid perovskite materials. Here, we report on the inclusion of liquid-phase exfoliated molybdenum disulfide nanosheets into different perovskite precursor solutions, exploring their influence on final device performance. We compared the effect of such additives upon the growth of diverse perovskites, namely CH3NH3PbI3 (MAPbI3 ) and triple-cation with mixed halides Csx (MA0.17FA0.83 )(1−x)Pb (I0.83Br0.17 )3 perovskite. We show how for the referential MAPbI3 materials the addition of the MoS2 additive leads to the formation of larger, highly crystalline grains, which result in a remarkable 15% relative improvement in power conversion efficiency. On the other hand, for the mixed cation– halide perovskite no improvements were observed, confirming that the nucleation process for the two materials is differently influenced by the presence of MoS2 .publishersversionpublishe

Clustering of risk factors in hypertensive insulin-dependent diabetics with high sodium-lithium countertransport

Clustering of risk factors in hypertensive insulin-dependent diabetics with high sodium-lithium countertransport. Diabetic nephropathy is more common in patients with a positive family history of hypertension and with elevated red blood cell sodium-lithium countertransport, a marker of risk for essential hypertension. To evaluate whether there is a relationship between this cation transport system and indicators of risk of renal and cardiovascular complications in diabetic patients before the development of clinical proteinuria, we studied 31 type 1 (insulin-dependent) diabetic patients with arterial hypertension, without clinical proteinuria and 12 normotensive normoalbuminuric diabetic patients. Sodium-lithium countertransport activity was significantly higher in hypertensive patients (0.43 ± 0.03 mmol/1 RBC x hr) than in normotensive patients (0.23 ± 0.03; P < 0.001). To better explore the nature of the association between this transport system and arterial hypertension, hypertensive patients were divided in two groups, with high (>0.41 mmol/1 RBC x hr) or normal (<0.41) sodium-lithium countertransport activity. The two groups of hypertensive diabetics were similar in age, sex, body mass index and blood pressure levels. Hypertensive patients with elevated rates of sodium-lithium counter-transport compared with those with normal sodium-lithium counter-transport activity showed elevated glomerular filtration rate (130 ± 4 ml/min/1.73 m2 vs. 122 ± 3; P < 0.05), albumin excretion rate (median 26 /Lcg/min vs. 11; P < 0.001), higher fractional proximal sodium reabsorption (74 ± 1.2% vs. 71.6 ± 0.9; P < 0.01), exchangeable sodium pool (2937 ± 62 mmol/1.73 m2 vs. 2767 ± 56; P < 0.01), larger kidney volume (317 ± 7 ml/1.73 m2 vs. 270 ± 8; P < 0.05) and left ventricular mass index (122 ± 4 g/m2 vs. 107 ± 5; P < 0.05). Hypertensive patients with normal sodium-lithium countertransport activity had renal parameters similar to normotensive diabetic patients, except higher left ventricular mass index and kidney volume. Hypertensive diabetic patients with elevated sodium-lithium countertransport activity also had higher levels of plasma triglycerides, lower plasma HDL-cholesterol and impaired insulin sensitivity (assessed by euglyce-mic insulin-glucose clamp) compared with the other two groups. In conclusion, renal, cardiac and metabolic abnormalities are prominent in hypertensive type 1 (insulin-dependent) diabetic patients with higher sodium-lithium countertransport

Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms

A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells 6510,000/ml (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN

Proposal validation of a phenomenoogical model for predicting the vehicular environmental impact

Pollutant concentrations in urban canyon mainly come from vehicular emissions. The search of a quantitative relationship, linking pollutant emissions from mobile sources to the resulting concentrations, at different receptor sites, has brought us to develop a phenomenological model able to calculate the number of running vehicles once the pollutant ground level concentration of CO is known. Unfortunately, we haven't the possibility to test this model by a direct inspection of the traffic flow. Despite this fact it is our aim to validate the proposed traffic model. Mathematical models are considered useful tools in supporting air quality evaluations. The structure of the models usually embodies the main aspects of the phenomenon and is supposed to provide information about the relationships between pollutant emissions and concentrations. As it is well known, there exist several typologies of models, differentiating each other by levels of complexity and fields of application. In this work an early simulation has been performed by using a commercial available pollution model. First comparisons of the CO concentrations, obtained by using as input of the mathematical model the number of vehicles predicted by the phenomenological model, against the measured data of CO concentrations, show that the proposed traffic model realistically reproduces the characteristic of the traffic flows, at least in the selected town context. The feasibility of the model to be applied in other urban situations that one selected for the validation is also discussed in the paper

Functional relationships between emission by cars and urban pollutant concentrations: a simplified phenomenological approach

This work is aimed at providing a contribution toward the singling out of a functional relationship between the traffic flow in urban contexts and the physical dynamic of the pollutant diffusion. The values of CO concentrations in selected sites of the urban layout are obtained by utilizing as input the number of vehicles predicted by the phenomenological model here introduced. This represents a quite different approach in the simulation of the pollutant dynamics in urban contexts. One of the main features of the proposed traffic model, is the capability of realistically reproducing the characteristic of the traffic flows. The feasibility of the model to be applied in other urban situations is discussed in the paper along with the possible ways of validating it

Comparison of methodologies for Test Reference Year (TRY) generation for Mediterranean sites

The improvement of the energy efficiency of buildings calls for the availability of tools for evaluating and simulating the thermal behaviour of buildings. These simulation tools generally need a complete input data set and, in particular, information referring to the climatic conditions of the site where buildings are built-up. Among climatic issues, particularly important for the thermal energy balance is the solar radiation. However, this huge mass of data is not very useful in this form, so simple aggregation methods have been developed in order to run these simulation computer programs: the test reference year (TRY) is one of the most used methods. In this paper the comparison of two methodologies for compiling TRY of the solar radiation is presented. The two methodologies, elaborated respectively by Dogniaux and Finkelstein-Schafer, have both a statistical approach to the problem. The first one is based on the normal distribution of the monthly average of each climatic parameter and his variance, while the second one is a more powerful version of the Kolmogorov-Smirnov test, based on the cumulative probability function. The two methods give quite different results, suggesting a particular caution in the choice of the method for generating such reduced sets of data

Atypical Chronic Myeloid Leukemia: Where Are We Now?

Atypical chronic myeloid leukemia, BCR-ABL1 negative (aCML) is a rare myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) with a high rate of transformation to acute myeloid leukemia, and poor survival. Until now, the diagnosis has been based on morphological grounds only, possibly making the real frequency of the disease underestimated. Only recently, new insights in the molecular biology of MDS/MPN syndromes have deepened our knowledge of aCML, enabling us to have a better molecular profile of the disease. The knowledge gleaned from next generation sequencing has complemented morphologic and laboratory WHO criteria for myeloid neoplasms and can provide greater specificity in distinguishing aCML from alternative MDS/MPN or MPNs. The most commonly mutated genes (&gt;20%) in aCML are SETBP1, ASXL1, N/K-RAS, SRSF2, and TET2, and less frequently (&lt; 10%) CBL, CSFR3, JAK2, EZH2, and ETNK1. Several of these mutations affect the JAK-STAT, MAPK, and ROCK signaling pathways, which are targetable by inhibitors that are already in clinical use and may lead to a personalized treatment of aCML patients unfit for allogeneic transplant, which is currently the only curative option for fit patients. In this review, we present two emblematic clinical cases and address the new molecular findings in aCML and the available treatment options