The observational analysis of elite coaches within youth soccer: The importance of performance analysis

The study investigated the observational capabilities of experienced elite coaches whilst focusing upon soccer specific actions and playing positions within elite youth soccer. Six soccer coaches assessed the performances of 10 youth soccer players (across 8 matches) on their short/long passing, tackling, shooting, heading and dribbling. Analysis was undertaken on an overall, quality and positional grouping basis. Mean observational accuracy was 38.8%, with successful shooting (78.6%) and passing (29.9%) illustrating the range. The limited effective observation of dribbling (37.2%), often considered a separating factor within talent identification, highlights the need for objective measures to aid such processes. Positional grouping analysis elicited 20% more effective observation for unsuccessful compared with successful actions. The poor level of observational accuracy identified herein has significant implications on talent identification assessments devoid of post-performance analyses. The findings reinforce the importance of performance analysis in the provision of highly accurate and comprehensive augmented feedback within the coaching process

Complement components as potential therapeutic targets for asthma treatment

SummaryAsthma is the most common respiratory disorder, and is characterized by distal airway inflammation and hyperresponsiveness. This disease challenges human health because of its increasing prevalence, severity, morbidity, and the lack of a proper and complete cure. Asthma is characterized by TH2–skewed inflammation with elevated pulmonary levels of IL-4, IL-5, and IL-13 levels. Although there are early forays into targeting TH2 immunity, less-specific corticosteroid therapy remains the immunomodulator of choice. Innate immune injury mediated by complement components also act as potent mediators of the allergic inflammatory responses and offer a new and exciting possibility for asthma immunotherapy. The complement cascade consists of a number of plasma- and membrane-bound proteins, and the cleavage products of these proteins (C3 and C5) regulate the magnitude of adaptive immune responses. Complement protein are responsible for many pathophysiological features of asthma, including inflammatory cell infiltration, mucus secretion, increases in vascular permeability, and smooth muscle cell contraction. This review highlights the complement-mediated injury during asthma inflammation, and how blockade of active complement mediators may have therapeutic application

Radar detection of a localized 1.4 Hz pulsation in auroral plasma, simultaneous with pulsating optical emissions, during a substorm

Many pulsating phenomena are associated with the auroral substorm. It has been considered that some of these phenomena involve kilometer-scale Alfvén waves coupling the magnetosphere and ionosphere. Electric field oscillations at the altitude of the ionosphere are a signature of such wave activity that could distinguish it from other sources of auroral particle precipitation, which may be simply tracers of magnetospheric activity. Therefore, a ground based diagnostic of kilometer-scale oscillating electric fields would be a valuable tool in the study of pulsations and the auroral substorm. In this study we attempt to develop such a tool in the Poker Flat incoherent scatter radar (PFISR). The central result is a statistically significant detection of a 1.4 Hz electric field oscillation associated with a similar oscillating optical emission, during the recovery phase of a substorm. The optical emissions also contain a bright, lower frequency (0.2 Hz) pulsation that does not show up in the radar backscatter. The fact that higher frequency oscillations are detected by the radar, whereas the bright, lower frequency optical pulsation is not detected by the radar, serves to strengthen a theoretical argument that the radar is sensitive to oscillating electric fields, but not to oscillating particle precipitation. Although it is difficult to make conclusions as to the physical mechanism, we do not find evidence for a plane-wave-like Alfvén wave; the detected structure is evident in only two of five adjacent beams. We emphasize that this is a new application for ISR, and that corroborating results are needed

Macrophages in solid organ transplantation

Macrophages are highly plastic hematopoietic cells with diversified functions related to their anatomic location and differentiation states. A number of recent studies have examined the role of macrophages in solid organ transplantation. These studies show that macrophages can induce allograft injury but, conversely, can also promote tissue repair in ischemia-reperfusion injury and acute rejection. Therapeutic strategies that target macrophages to improve outcomes in solid organ transplant recipients are being examined in preclinical and clinical models. In this review, we discuss the role of macrophages in different types of injury and rejection, with a focus on macrophage-mediated tissue injury, specifically vascular injury, repair and remodeling. We also discuss emerging macrophage-centered therapeutic opportunities in solid organ transplantation

GPS TEC observations of dynamics of the mid‐latitude trough during substorms

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95166/1/grl28288.pd

Magnetic aspect sensitivity of high‐latitude E region irregularities measured by the RAX‐2 CubeSat

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106761/1/jgra50801.pd

Medical termination of pregnancy in general practice in Australia: A descriptive-interpretive qualitative study

© 2017 The Author(s). Background: Australian Government approval in 2012 for the use of mifepristone and misoprostol for medical termination of pregnancy (MTOP) allows general practitioners (GPs) to provide early gestation abortion in primary care settings. However, uptake of the MTOP provision by GPs appears to be low and the reasons for this have been unclear. This study investigated the provision of and referral for MTOP by GPs. Methods: We undertook descriptive-interpretive qualitative research and selected participants for diversity using a matrix. Twenty-eight semi-structured interviews and one focus group (N = 4), were conducted with 32 GPs (8 MTOP providers, 24 non MTOP providers) in New South Wales, Australia. Interviews were recorded and transcribed verbatim. A framework to examine access to abortion services was used to develop the interview questions and emergent themes identified thematically. Results: Three main themes emerged: scope of practice; MTOP demand, care and referral; and workforce needs. Many GPs saw abortion as beyond the scope of their practice (i.e. a service others provide in specialist private clinics). Some GPs had religious or moral objections; others regarded MTOP provision as complicated and difficult. While some GPs expressed interest in MTOP provision they were concerned about stigma and the impact it may have on perceptions of their practice and the views of colleagues. Despite a reported variance in demand most MTOP providers were busy but felt isolated. Difficulties in referral to a local public hospital in the case of complications or the provision of surgical abortion were noted. Conclusions: Exploring the factors which affect access to MTOP in general practice settings provides insights to assist the future planning and delivery of reproductive health services. This research identifies the need for support to increase the number of MTOP GP providers and for GPs who are currently providing MTOP. Alongside these actions provision in the public sector is required. In addition, formalised referral pathways to the public sector are required to ensure timely care in the case of complications or the provision of surgical options. Leadership and coordination across the health sector is needed to facilitate integrated abortion care particularly for rural and low income women

Simultaneously Targeting Myofibroblast Contractility and Extracellular Matrix Crossâ Linking as a Therapeutic Concept in Airway Fibrosis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136664/1/ajt14103-sup-0002-FigureS2.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136664/2/ajt14103-sup-0003-FigureS3.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136664/3/ajt14103.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136664/4/ajt14103_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136664/5/ajt14103-sup-0001-FigureS1.pd

Imaging radar observations of Farley Buneman waves during the JOULE II experiment

Vector electric fields and associated <I><B>E</B></I>×<I><B>B</B></I> drifts measured by a sounding rocket in the auroral zone during the NASA JOULE II experiment in January 2007, are compared with coherent scatter spectra measured by a 30 MHz radar imager in a common volume. Radar imaging permits precise collocation of the spectra with the background electric field. The Doppler shifts and spectral widths appear to be governed by the cosine and sine of the convection flow angle, respectively, and also proportional to the presumptive ion acoustic speed. The neutral wind also contributes to the Doppler shifts. These findings are consistent with those from the JOULE I experiment and also with recent numerical simulations of Farley Buneman waves and instabilities carried out by Oppenheim et al. (2008). Simple linear analysis of the waves offers some insights into the spectral moments. A formula relating the spectral width to the flow angle, ion acoustic speed, and other ionospheric parameters is derived

Comparing VHF coherent scatter from the radar aurora with incoherent scatter and all-sky auroral imagery

VHF coherent scatter radar observations of an auroral substorm over Alaska are analyzed in the context of multibeam incoherent scatter plasma density and drifts data and green-line all-sky optical imagery. Coherent scatter arises from Farley Buneman waves which are excited in theEregion whenever the convection electric field is greater than about 20 mV/m. Aperture synthesis radar imaging and other aspects of the methodology facilitate the precise spatial registration of the coherent scatter with coincident optical and incoherent scatter radar measurements. Discrete auroral arcs were found to separate diffuse regions of coherent backscatter and, sometimes, to align with the boundaries of those regions. At other times, auroral arcs and torches lined up adjacent to discrete, structured regions or radar backscatter. Drastic variations in the Doppler shifts of the coherent scatter from one side of the auroral forms to the other suggest the presence of field-aligned currents. An empirical formula based on previous studies but adapted to account approximately for the effects of wave turning was used to estimate the convection electric field from the moments of the coherent scatter Doppler spectra. Line-of-sightF region plasma drift measurements from the Poker Flat Incoherent Scatter Radar (PFISR) were found to be in reasonable agreement with these convection field estimates. Reasons why the empirical formulas may be expected to hold are discussed