[unknown]

原著和名: [記載なし]科名: マメ科 = Leguminosae採集地: タイ バンコク市内 (タイ国 バンコク市内)採集日: 1984/10/10採集者: 萩庭丈壽整理番号: JH050727国立科学博物館整理番号: TNS-VS-999700備考: 栽培

Serotype and clonal complex distribution of penicillin non-susceptible (PNS) and multidrug-resistant (MDR) isolates causing invasive pneumococcal disease in South Africa, 2007.

1<p>Only clonal complexes/singletons with at least one penicillin non-susceptible (PNS) isolate are reflected in the table;</p>2<p>Percentage of isolates that are penicillin non-susceptible within the specified clonal complex,</p>3<p>Percentage of isolates that are multi-drug resistant (MDR) within the specified clonal complex.</p><p>Serotype and clonal complex distribution of penicillin non-susceptible (PNS) and multidrug-resistant (MDR) isolates causing invasive pneumococcal disease in South Africa, 2007.</p

Population Snapshot of <i>Streptococcus pneumoniae</i> Causing Invasive Disease in South Africa Prior to Introduction of Pneumococcal Conjugate Vaccines

<div><p>We determined the sequence types of isolates that caused invasive pneumococcal disease (IPD) prior to routine use of pneumococcal conjugate vaccines (PCV) in South Africa. PCV-13 serotypes and 6C isolates collected in 2007 (1 461/2 437, 60%) from patients of all ages as part of on-going, national, laboratory-based surveillance for IPD, were selected for genetic characterization. In addition, all 134 non-PCV isolates from children <2 years were selected for characterization. Sequence type diversity by serotype and age category (children <5 years vs. individuals ≥5 years) was assessed for PCV serotypes using Simpson’s index of diversity. Similar genotypes circulated among isolates from children and adults and the majority of serotypes were heterogeneous. While globally disseminated clones were common among some serotypes (e.g., serotype 1 [clonal complex (CC) 217, 98% of all serotype 1] and 14 [CC230, 43%)]), some were represented mainly by clonal complexes rarely reported elsewhere (e.g., serotype 3 [CC458, 60%] and 19A [CC2062, 83%]). In children <2 years, serotype 15B and 8 were the most common serotypes among non-PCV isolates (16% [22/134] and 15% [20/134] isolates, respectively). Sequence type 7052 and 53 were most common among serotypes 15B and 8 isolates and accounted for 58% (7/12) and 64% (9/14) of the isolates, respectively. Serotype 19F, 14, 19A and 15B had the highest proportions of penicillin non-susceptible isolates. Genotypes rarely reported in other parts of the world but common among some of our serotypes highlight the importance of our data as these genotypes may emerge post PCV introduction.</p></div

Distribution of pneumococcal serotypes causing invasive disease in South Africa, by age group, 2007 (n = 3 194).

<p>‘Other’ indicates serotypes not included in pneumococcal conjugate vaccines (PCV-13 and 6C).</p

Clonal complex and sequence type distribution of pneumococcal conjugate vaccine serotype isolates causing invasive pneumococcal disease in South Africa, 2007 (n = 1 064).

<p>Clonal complex and sequence type distribution of pneumococcal conjugate vaccine serotype isolates causing invasive pneumococcal disease in South Africa, 2007 (n = 1 064).</p

Diversity of sequence types within serotypes.

<p>Simpson’s index of diversity was used to assess diversity of isolates that caused invasive pneumococcal disease in 2007 among individuals of all ages, South Africa.</p

Sequence type distribution among pneumocoocal non-conjugate vaccine serotype pneumococci causing invasive disease in South African children <2 years (n = 74), 2007.

1<p>Other serotypes associated with this sequence type (as listed in the MLST global database <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107666#pone.0107666-Aanensen2" target="_blank">[28]</a>) but not identified in this study, are within parantheses.</p><p>Sequence types representing isolates with reduced susceptibility to penicillin are in bold typeface.</p><p>Sequence type distribution among pneumocoocal non-conjugate vaccine serotype pneumococci causing invasive disease in South African children <2 years (n = 74), 2007.</p

[unknown]

原著和名: [記載なし]科名: マメ科 = Leguminosae採集地: 台湾 亀山 (台湾 亀山)採集日: 1968/8/27採集者: 萩庭丈壽整理番号: JH048508国立科学博物館整理番号: TNS-VS-99850

NGS data and assembly metrics.

<p>NGS data and assembly metrics.</p

Similarity of 16F-like capsular polysaccharide (<i>cps</i>) gene loci.

<p>Sequences from pneumococci serotyped as 16F Quellung but sequetyped as 9V was compared to reference 9V (CR931648) and 16F (CR931668) <i>cps</i> sequences. Artemis Comparison Tool (ACT) was used to generate and view gene homology. The top lines represent the forward and reverse strand of a serotype 9v reference, the middle lines represent the queried 16F strain and the bottom lines shows the 16F reference. The portion of the <i>wzh</i> gene that is amplified by the sequetyping assay is shown by the blue rectangle. The clear blocks below the blue box shows regions were the genes that are not similar. BLASTN matches are shown as red bands between sequences, indicating the degree of similarity between the sequences.</p