Additional file 1: of Inflammatory profiles in canine intervertebral disc degeneration

A more detailed representation of included samples in addition to Table  1 in the original article. (DOCX 29 kb

Additional file 2: of Inflammatory profiles in canine intervertebral disc degeneration

Significant differences and confidence intervals of statistical analyses. (DOCX 25 kb

Additional file 3 of Evaluation of gold fiducial marker manual localisation for magnetic resonance-only prostate radiotherapy

Single patient investigation. As a supplementary material, we report CT and MRI images for the patients P4 and P6, which were found having LoA >2 mm in maximum one of the three FMs for localisation performed with multiple sequences. Zoom of an axial slice of CT (top left), bSSFP (top centre-left), SPGR (top centre-right) and GRE (top right) images for the patients P4, P6 before image registration as well as schematic representations of the centres of the FMs as localised by all the observers (bottom) are shown in Figs. 1 and 2, respectively. For completeness, we report also the CT ad MRI images along with the schematic representation of the centres of the FM for patient P14 in Fig. 3. Note that this patient was not considered during the analysis since had a hip implant. (PDF 1823 kb

Additional file 2 of Evaluation of gold fiducial marker manual localisation for magnetic resonance-only prostate radiotherapy

Annotations on the FM localisation. As part of the supplementary material, we report the apparent length of the FMs for each observer and the time spent by each observer performing the FM localisation over all the patients. In particular, Table 1 shows the mean, standard deviation (STD), range [min, max] of the apparent length, expressed in mm. The weighted mean over all the observer is 7.5Âą0.6 mm and 7.7Âą0.7 mm for localisation using a single and multiple sequences, respectively. Note that the apparent length was longer than the nominal length of the FM (5 mm). Table 2 reports the mean, STD and range of the time needed by each observer to perform the FM localisation using single and multiple sequences. The weighted mean over all the observer is 5.8Âą1.4 min. Note that all the RTTs localised the FMs first using a single and then multiple sequences for all the patients. The RTTs were free to chose the order of patients and whether concluding the procedure first for each the patients using both single and multiple sequences or first for all the patients using single sequence and then repeat for all the patients using multiple modalities. Possible differences in the way the RTTs performed the procedure does not permit to understand whether the FM localisation is faster using single or multiple sequences. In addition, a histogram reporting the frequency of unreliable FM localisation, as perceived by the RTTs is shown in Fig. 1 for four out of five observers; one of the observers did not report the reliability of the localisation. The observers reported the perceived reliability without distinction between localisation performed employing a single and multiple sequences. (PDF 108 kb

Additional file 4: of Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model

PGE 2 normalized for total protein. (TIFF 15443 kb

Additional file 1: of Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model

Synthesis and degradation of poly-N-isopropylacrylamide (pNIPAAM) MgFe-LDH hydrogels and controlled release of CXB in vitro. (DOCX 89 kb