Reagents and conditions: (a) SeO₂, t-BuOOH, CH₂Cl₂, r.t; (b) DAST, CH₂Cl₂, 0°C.

<p>Reagents and conditions: (a) SeO₂, t-BuOOH, CH₂Cl₂, r.t; (b) DAST, CH₂Cl₂, 0°C.</p

Lack of effect of 3 (10 and 30 mg/kg, n = 7–8 animals/group) in Swiss male mice tested in the pre-pulse inhibition model.

<p>Animals received a first injection of vehicle (V) or <b>3</b> followed, 30 min later, by vehicle (n = 7) or amphetamine 10 mg/kg (V+amphetamine group = 7 animals). Data represents the means+SEM. *indicates difference from V+V group (ANOVA followed by the Duncan test, p<0.05).</p

Effect of 1 (1, 3 and 10 mg/kg, n = 7, 6 and 15 animals, respectively) in Swiss male mice tested in the pre-pulse inhibition model.

<p>Animals received a first injection of vehicle (V) or <b>1</b> followed, 30 min later, by vehicle (n = 9) or amphetamine 10mg/kg (V+amphetamine group = 11 animals). *indicates difference from V+V group. + indicates difference from V+amphetamine group (ANOVA followed by the Duncan test, p<0.05).</p

Lack of effect of 2 (10, 30 and 60 mg/kg, n = 7–8 animals/group) in Swiss male mice tested in the pre-pulse inhibition model.

<p>Animals received a first injection of vehicle (V) or 2 followed, 30 min later, by vehicle (n = 12) or amphetamine 10 mg/kg (V+amphetamine group = 11 animals). *indicates difference from V+V group (ANOVA followed by the Duncan test, p<0.05).</p

Reagents and conditions: (a) 1-fluoropyridinium triflate, CH₂Cl₂, r.t.

<p>Reagents and conditions: (a) 1-fluoropyridinium triflate, CH₂Cl₂, r.t.</p

Effect of 3 (1, 3 and 10 mg/kg, n = 5, 5 and 6 animals, respectively) in Swiss male mice tested in the forced swim test (FST, upper panel) and elevated plus maze (EPM).

<p>*indicates difference from V group (ANOVA followed by the Duncan test, p<0.05). Further specification as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0158779#pone.0158779.g004" target="_blank">Fig 4</a>.</p

Lack of effect of 5a (3, 10 and 30 mg/kg, n = 8 animals/group) in Swiss male mice tested in the pre-pulse inhibition model.

<p>Animals received a first injection of vehicle (V) or <b>5a</b> followed, 30 min later, by vehicle or amphetamine 10 mg/kg (V+amphetamine). *indicates difference from V+V group (ANOVA followed by the Duncan test, p<0.05). Further specifications as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0158779#pone.0158779.g007" target="_blank">Fig 7</a>.</p

CBD (30–60 mg/kg, n = 10–11 animals/group), HUF-101 (10 mg/kg, n = 13–14 animals/group) and fluoxetine (10 mg/kg, n = 10 animals) decreased the number of buried marbles in the MBT test.

<p>*indicates difference from V+V group (ANOVA followed by the Duncan test, p<0.05).</p