P213: Exploring heterogeneity among gene lists proposed for newborn sequencing

peer reviewe

Acercamiento plurilingüe y multicultural a la Constitución Europea

Este proyecto se elabora con motivo de la celebración del referéndum para ratificar el Tratado por el que se establece una Constitución para Europa. Su finalidad principal es fomentar las relaciones entre las sociedades europeas de habla inglesa, francesa, alemana y española, y acercar estas lenguas a los alumnos. Los objetivos son dar a conocer la Constitución Europea; mostrar la diversidad cultural y lingüística de Europa; promover el aprendizaje de más de una lengua extranjera; y establecer contactos con alumnos y profesores de otros países europeos. Con anterioridad a la celebración en España del referéndum sobre la Constitución Europea, los alumnos recopilan información sobre este texto y sobre los países de la Unión Europea. Además, realizan debates y asisten a una conferencia impartida en español, francés, alemán e inglés. Una vez realizado el referéndum, se analizan los resultados. En los meses posteriores se estudian los procesos de ratificación iniciados en otros países y al final de curso se lleva a cabo un viaje a Bruselas. Otras actividades son la lectura de prensa en alemán, francés e inglés; la búsqueda de información en Internet en varios idiomas; y el establecimiento de contactos con profesores y estudiantes alemanes, belgas, británicos y franceses. Además, se decora el centro con carteles informativos. Se elaboran varios materiales para ampliar conocimientos sobre la Unión Europea y su Constitución y, a la vez, aprender idiomas. Una muestra de los mismos, junto con otros recursos utilizados, se adjunta en formato papel y en disquete. También se incluyen varias fotografías.Madrid (Comunidad Autónoma). Consejería de Educación. Dirección General de Ordenación AcadémicaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES

Acercamiento plurilingüe y multicultural a la Constitución Europea

Este proyecto se elabora con motivo de la celebración del referéndum para ratificar el Tratado por el que se establece una Constitución para Europa. Su finalidad principal es fomentar las relaciones entre las sociedades europeas de habla inglesa, francesa, alemana y española, y acercar estas lenguas a los alumnos. Los objetivos son dar a conocer la Constitución Europea; mostrar la diversidad cultural y lingüística de Europa; promover el aprendizaje de más de una lengua extranjera; y establecer contactos con alumnos y profesores de otros países europeos. Con anterioridad a la celebración en España del referéndum sobre la Constitución Europea, los alumnos recopilan información sobre este texto y sobre los países de la Unión Europea. Además, realizan debates y asisten a una conferencia impartida en español, francés, alemán e inglés. Una vez realizado el referéndum, se analizan los resultados. En los meses posteriores se estudian los procesos de ratificación iniciados en otros países y al final de curso se lleva a cabo un viaje a Bruselas. Otras actividades son la lectura de prensa en alemán, francés e inglés; la búsqueda de información en Internet en varios idiomas; y el establecimiento de contactos con profesores y estudiantes alemanes, belgas, británicos y franceses. Además, se decora el centro con carteles informativos. Se elaboran varios materiales para ampliar conocimientos sobre la Unión Europea y su Constitución y, a la vez, aprender idiomas. Una muestra de los mismos, junto con otros recursos utilizados, se adjunta en formato papel y en disquete. También se incluyen varias fotografías.Madrid (Comunidad Autónoma). Consejería de Educación. Dirección General de Ordenación AcadémicaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES

Which one? A comparative study of traditional and sports uniforms on academic achievement, cognitive performance, playtime, bullying, and discrimination in adolescents: The Cogni-Action Project.

The aim of this study was to compare academic achievement, cognitive performance, playtime, bullying, and discrimination in adolescents according to traditional uniforms (TUs) and sports uniforms (SUs) worn at school, while simultaneously exploring the influence of the school vulnerability index. A total of 988 Chilean adolescents (52.6% boys) aged 10-14 years participated in this cross-sectional study. Academic achievement was evaluated by the average grade in maths, language, and science grades, while cognitive performance was assessed through eight cognitive tasks. TUs affecting physical activity, playtime, bullying, and discrimination were queried. Mixed model analyses were performed. No differences were observed in academic achievement (TU: 5.4 ± 0.1 vs. SU: 5.5 ± 0.2, p = 0.785) or in cognitive performance (TU: 99.6 ± 0.8 vs. SU: 98.9 ± 1.8, p= 0.754) according to the school uniformtype. Moreover, 64.1 % of participants declared that wearing TU affects their physical activity (traditional uniforms: + 8 min and sports uniforms: + 20 min), and those who believed so spent more time playing than those who answered negatively (14.5 min, p = 0.012). Finally, adolescents wearing SU displayed a lower feeling of bullying and discrimination; this finding depended mainly on the school's vulnerability. It is concluded that wearing TU does not show an educational advantage at an academic and cognitive level that justifies its obligation. In addition, it could be suggested that schools consider adolescents' opinions in adopting a more comfortable uniform, such as the SU. This feasible and low-cost measure would help to increase adolescents' physical activity during the school day, and, contrary to belief, it would not be related to increased feelings of bullying and discrimination

Plasma exchange in the intensive care unit: a narrative review

International audienc

Respiratory Mechanics and Outcomes in Immunocompromised Patients With ARDS: A Secondary Analysis of the EFRAIM Study

Background: In view of the high mortality rate of immunocompromised patients with ARDS, it is important to identify targets for improvement. Research Question: This study investigated factors associated with mortality in this specific ARDS population, including factors related to respiratory mechanics (plateau pressure [Pplat,rs], compliance [Crs], and driving pressure [ΔPrs]). Study Design and Methods: This study consisted of a predefined secondary analysis of the EFRAIM data. Overall, 789 of 1,611 patients met the Berlin criteria for ARDS, and Pplat,rs, ΔPrs, and Crs were available for 494 patients. A hierarchical model was used to assess factors at ARDS onset independently associated with hospital mortality. Results: Hospital mortality was 56.3%. After adjustment, variables independently associated with hospital mortality included ARDS of undetermined etiology (OR, 1.66; 95% CI, 1.01-2.72), need for vasopressors (OR, 1.91; 95% CI, 1.27-2.88), and need for renal replacement therapy (OR, 2.02; 95% CI, 1.37-2.97). ARDS severity according to the Berlin definition, neutropenia on admission, and the type of underlying disease were not significantly associated with mortality. Before adjustment, higher Pplat,rs, higher ΔPrs, and lower Crs were associated with higher mortality. Addition of each of these individual variables to the final hierarchical model revealed a significant association with mortality: ΔPrs (OR, 1.08; 95% CI, 1.05-1.12), Pplat,rs (OR, 1.07; 95% CI, 1.04-1.11), and Crs (OR, 0.97; 95% CI, 0.95-0.98). Tidal volume was not associated with mortality. Interpretation: In immunocompromised patients with ARDS, respiratory mechanics provide additional prognostic information to predictors of hospital mortality. Studies designed to define lung-protective ventilation guided by these physiological variables may be warranted in this specific population

Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study

Background: In immunocompromised patients with acute hypoxemic respiratory failure (ARF), initial management aims primarily to avoid invasive mechanical ventilation (IMV). Methods: To assess the impact of initial management on IMV and mortality rates, we performed a multinational observational prospective cohort study in 16 countries (68 centers). Results: A total of 1611 patients were enrolled (hematological malignancies 51.9%, solid tumors 35.2%, systemic diseases 17.3%, and solid organ transplantation 8.8%). The main ARF etiologies were bacterial (29.5%), viral (15.4%), and fungal infections (14.7%), or undetermined (13.2%). On admission, 915 (56.8%) patients were not intubated. They received standard oxygen (N = 496, 53.9%), high-flow oxygen (HFNC, N = 187, 20.3%), noninvasive ventilation (NIV, N = 153, 17.2%), and NIV + HFNC (N = 79, 8.6%). Factors associated with IMV included age (hazard ratio = 0.92/year, 95% CI 0.86â\u80\u930.99), day-1 SOFA (1.09/point, 1.06â\u80\u931.13), day-1 PaO2/FiO2(1.47, 1.05â\u80\u932.07), ARF etiology (Pneumocystis jirovecii pneumonia (2.11, 1.42â\u80\u933.14), invasive pulmonary aspergillosis (1.85, 1.21â\u80\u932.85), and undetermined cause (1.46, 1.09â\u80\u931.98). After propensity score matching, HFNC, but not NIV, had an effect on IMV rate (HR = 0.77, 95% CI 0.59â\u80\u931.00, p = 0.05). ICU, hospital, and day-90 mortality rates were 32.4, 44.1, and 56.4%, respectively. Factors independently associated with hospital mortality included age (odds ratio = 1.18/year, 1.09â\u80\u931.27), direct admission to the ICU (0.69, 0.54â\u80\u930.87), day-1 SOFA excluding respiratory score (1.12/point, 1.08â\u80\u931.16), PaO2/FiO2 < 100 (1.60, 1.03â\u80\u932.48), and undetermined ARF etiology (1.43, 1.04â\u80\u931.97). Initial oxygenation strategy did not affect mortality; however, IMV was associated with mortality, the odds ratio depending on IMV conditions: NIV + HFNC failure (2.31, 1.09â\u80\u934.91), first-line IMV (2.55, 1.94â\u80\u933.29), NIV failure (3.65, 2.05â\u80\u936.53), standard oxygen failure (4.16, 2.91â\u80\u935.93), and HFNC failure (5.54, 3.27â\u80\u939.38). Conclusion: HFNC has an effect on intubation but not on mortality rates. Failure to identify ARF etiology is associated with higher rates of both intubation and mortality. This suggests that in addition to selecting the appropriate oxygenation device, clinicians should strive to identify the etiology of ARF