8 research outputs found
Survival according to UICC tumour stage (7 patients who died peroperatively were excluded from the analysis)
<p><b>Copyright information:</b></p><p>Taken from "Surgical outcomes for colon and rectal cancer over a decade: results from a consecutive monocentric experience in 902 unselected patients"</p><p>http://www.wjso.com/content/5/1/73</p><p>World Journal of Surgical Oncology 2007;5():73-73.</p><p>Published online 4 Jul 2007</p><p>PMCID:PMC1959229.</p><p></p
Supplementary Material for: The Clinicopathologic Heterogeneity of Grade 3 Gastroenteropancreatic Neuroendocrine Neoplasms: Morphological Differentiation and Proliferation Identify Different Prognostic Categories
<b><i>Background/Aims:</i></b> Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are defined as neuroendocrine neoplasms (NENs) with a Ki-67 index >20% according to the 2010 WHO classification. Some reports suggest that this category is heterogeneous. We retrospectively studied a series of 136 patients affected by grade 3 GEP-NECs with the aim to clarify the prognostic role of tumor morphological differentiation, proliferation, defect in mismatch repair proteins (MMRd), CD117 expression, and site of origin. The primary endpoint was the correlation between these parameters and the overall survival (OS). <b><i>Methods:</i></b> Univariate and multivariable Cox proportional hazards regression analyses were used to assess the prognostic significance of various clinical and histopathologic features. <b><i>Results:</i></b> With a median follow-up of 81 months, the median OS was 12.9 months. At multivariate analysis, morphological differentiation, Ki-67 index, MMRd, stage, and CD117 expression were independent prognostic markers in NECs. Three different prognostic categories of NECs were identified according to the degree of morphologic differentiation (well vs. poorly differentiated) and Ki-67 index (<55% vs. ≥55%). On this basis, median OS was 43.6 months in well-differentiated neoplasms with a Ki-67 index 20-55% (named type A), 24.5 months in poorly differentiated neoplasms with a Ki-67 index 20-55% (type B), and 5.3 months (p < 0.0001) in poorly differentiated neoplasms with a Ki-67 index ≥55% (type C). <b><i>Conclusions:</i></b> The present study suggests that GEP-NECs represent a heterogeneous group of neoplasms which can be better classified in different prognostic categories using both tumor morphology and Ki-67 index
Predictive factors of onset of first SRE.
<p>Predictive factors of onset of first SRE.</p
Predictive factors of survival after the development of the first SRE.
<p>Predictive factors of survival after the development of the first SRE.</p
Predictive factors of onset of bone metastasis.
<p><i>Abbreviations: CI, Confidence Interval; AFP, Alpha-fetoprotein; RFA, radiofrequency ablation; TACE, Transcatheter arterial chemoembolization; PEI, percutaneous ethanol injection.</i></p><p>Predictive factors of onset of bone metastasis.</p
Predictive factors of survival after HCC diagnosis.
<p>Predictive factors of survival after HCC diagnosis.</p
Predictive factors of survival after bone metastases diagnosis.
<p>Predictive factors of survival after bone metastases diagnosis.</p