Cols bleus : hebdomadaire de la Marine française

18 novembre 19951995/11/18 (N2327)-1995/11/18

Results of univariate analysis for BPE.

<p>Results of univariate analysis for BPE.</p

The correlation of background parenchymal enhancement in the contralateral breast with patient and tumor characteristics of MRI-screen detected breast cancers

<div><p>Purpose</p><p>Higher background parenchymal enhancement (BPE) could be used for stratification of MRI screening programs since it might be related to a higher breast cancer risk. Therefore, the purpose of this study is to correlate BPE to patient and tumor characteristics in women with unilateral MRI-screen detected breast cancer who participated in an intermediate and high risk screening program. As BPE in the affected breast may be difficult to discern from enhancing cancer, we assumed that BPE in the contralateral breast is a representative measure for BPE in women with unilateral breast cancer.</p><p>Materials and methods</p><p>This retrospective study was approved by our local institutional board and a waiver for consent was granted. MR-examinations of women with unilateral breast cancers screen-detected on breast MRI were evaluated by two readers. BPE in the contralateral breast was rated according to BI-RADS. Univariate analyses were performed to study associations. Observer variability was computed.</p><p>Results</p><p>Analysis included 77 breast cancers in 76 patients (age: 48±9.8 years), including 62 invasive and 15 pure ductal carcinoma in-situ cases. A negative association between BPE and tumor grade (p≤0.016) and a positive association with progesterone status (p≤0.021) was found. The correlation was stronger when only considering invasive disease. Inter-reader agreement was substantial.</p><p>Conclusion</p><p>Lower BPE in the contralateral breast in women with unilateral breast cancer might be associated to higher tumor grade and progesterone receptor negativity. Great care should be taken using BPE for stratification of patients to tailored screening programs.</p></div

Frequency of studies scored with BI-RADS categories 1, 2, 3 and 4 for (a) the complete dataset (n = 250) and (b) for the cases of the dataset with reference standard estimates (n = 186).

<p>Frequency of studies scored with BI-RADS categories 1, 2, 3 and 4 for (a) the complete dataset (n = 250) and (b) for the cases of the dataset with reference standard estimates (n = 186).</p

Patient and cancer characteristics.

<p>Patient and cancer characteristics.</p

Maximum Intensity Projection (MIP, top image) and subtraction image (bottom image) of woman with unilateral cancer (70 years old, breast tumor in the right breast, IDC grade 2) with BPE rated as moderate by both readers.

<p>Maximum Intensity Projection (MIP, top image) and subtraction image (bottom image) of woman with unilateral cancer (70 years old, breast tumor in the right breast, IDC grade 2) with BPE rated as moderate by both readers.</p

Comparison of breast volume obtained from MRI and FFDMs per (a) breast (n = 353) and (b) per study (n = 186).

<p>Comparison of breast volume obtained from MRI and FFDMs per (a) breast (n = 353) and (b) per study (n = 186).</p

Volpara Density Grade (VDG) versus BI-RADS density score from a breast radiologist.

<p>Volpara Density Grade (VDG) versus BI-RADS density score from a breast radiologist.</p

Summary of the dataset and the results obtained in this study.

<p>IQR = inter-quartile range,</p>*<p> = Pearson correlation coefficient,</p>+<p> = Spearman Ranked correlation coefficient,</p>−<p> = weighted kappa with quadratic weights coefficient.</p

Maximum Intensity Projection (MIP, top image) and subtraction image (bottom image) of woman with unilateral cancer (60 years old, breast tumor in the left breast, IDC grade 1) with BPE rated as marked by both readers.

<p>Maximum Intensity Projection (MIP, top image) and subtraction image (bottom image) of woman with unilateral cancer (60 years old, breast tumor in the left breast, IDC grade 1) with BPE rated as marked by both readers.</p