Raw data for A combined 3D in vitro - in silico approach to modelling bubble dynamics in decompression sickness

These are the Prism files which contain the raw data for the experimental bubble growth for variation in dive parameters and the experimental and simulated data for the oscillatory pressure profile

Flow chart of inclusions, non-inclusions and exclusions with the number of intubations available for analysis according to atropine use.

<p>Flow chart of inclusions, non-inclusions and exclusions with the number of intubations available for analysis according to atropine use.</p

The ECGs of four intubations are shown to demonstrate loss of beats.

<p>Strip ‘A’ shows heart rate variability from a minimum of 135 beats/min to a maximum of 165 beats/min which is similar to that of the one minute pre-intubation strip, no loss of beats is recorded. Strip ‘B’ shows variation form 175 beats/min to a short deceleration of 108 beats/min which results in the loss of one heart beat. Strip ‘C’ shows a longer deceleration from 110 to 67 beats/min which results in the loss of six beats and strip ‘D’ a prolonged deceleration from 142 to 87 beats/min which results in the loss of 25 beats.</p

Changes in heart rate during several different intubations.

<p>Two intubations (dotted and solid lines representing different intubations from separate children) are shown for comparison of how the loss of heart beats can be poorly correlated with reduction in heart rate. A, shows two intubations with similar fall in heart rate (fall HR) and more than 50 fold differences in lost beats, B, shows two intubations where the number of lost beats was similar but the fall in heart rate 50% greater, C, shows two examples where there was a more than a three-fold difference in lost beats against reduction in heart rate and D, is the one child who died in the study having lost 503 beats before an asystolic arrest. Inter-bradycardia tachycardia is also apparent in B. Note that the scales on the <i>x</i>-axes are different for each graph.</p

Population characteristics of the 245 children included.

*<p>Signifies a statistically significant difference, p<0.05.</p

Distribution of the lost beats with and without atropine (n = 130 for no-atropine and n = 115 for with atropine).

<p>The r² for no-atropine is 0.41 and 0.85 with atropine. Note the similarity between the two best-fit curves (dotted lines) both in terms of take off and position. All children survived intubation except that labelled ‘Died’.</p