A study of the boundary flow in a rocket combustion chamber. Part 3 - Data report Final report

Rocket motor boundary flow sampling apparatu

N-body Efimov states from two-particle noise

The ground state energies of universal N-body clusters tied to Efimov trimers, for N even, are shown to be encapsulated in the statistical distribution of two particles interacting with a background auxiliary field at large Euclidean time when the interaction is tuned to the unitary point. Numerical evidence that this distribution is log-normal is presented, allowing one to predict the ground-state energies of the N-body system.Comment: Extended discussion of results; published versio

A Tidally-Disrupted Asteroid Around the White Dwarf G29-38

The infrared excess around the white dwarf G29-38 can be explained by emission from an opaque flat ring of dust with an inner radius 0.14 of the radius of the Sun and an outer radius approximately equal to the Sun's. This ring lies within the Roche region of the white dwarf where an asteroid could have been tidally destroyed, producing a system reminiscent of Saturn's rings. Accretion onto the white dwarf from this circumstellar dust can explain the observed calcium abundance in the atmosphere of G29-38. Either as a bombardment by a series of asteroids or because of one large disruption, the total amount of matter accreted onto the white dwarf may have been comparable to the total mass of asteroids in the Solar System, or, equivalently, about 1% of the mass in the asteroid belt around the main sequence star zeta Lep.Comment: ApJ Letters, in pres

Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders

The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.Accepted manuscrip

Measuring the Effects of Workloss on Productivity With Team Production

Using data from a survey of 800 managers in 12 industries, we find empirical support for the hypothesis that the cost associated with missed work varies across jobs according to the ease with which a manager can find a perfect replacement for the absent worker, the extent to which the worker functions as part of a team, and the time sensitivity of the worker's output. We then estimate wage multipliers' for 35 different jobs, where the multiplier is defined as the cost to the firm of an absence as a proportion (often greater than one) of the absent worker's daily wage. The median multiplier is 1.28, which supports the view that the cost to the firm of missed work is often greater than the wage.

Community Benefits: How do For-Profit and Nonprofit Hospitals Measure up?

The rise of the for-profit hospital industry has opened a debate about the level of community benefits provided by non-profit hospitals. Do nonprofits provide enough community benefits to justify the community’s commitment of resources to them, and the tax-exempt status they receive? If nonprofit hospitals convert to for-profit entities, would community benefits be lost in the transaction? This debate has highlighted the need to define and measure community benefits more clearly. In this Issue Brief, the authors develop a new method of identifying activities that qualify as community benefits, and propose a benchmark for the amount of benefit a nonprofit hospital should provide

Breaking of ergodicity and long relaxation times in systems with long-range interactions

The thermodynamic and dynamical properties of an Ising model with both short range and long range, mean field like, interactions are studied within the microcanonical ensemble. It is found that the relaxation time of thermodynamically unstable states diverges logarithmically with system size. This is in contrast with the case of short range interactions where this time is finite. Moreover, at sufficiently low energies, gaps in the magnetization interval may develop to which no microscopic configuration corresponds. As a result, in local microcanonical dynamics the system cannot move across the gap, leading to breaking of ergodicity even in finite systems. These are general features of systems with long range interactions and are expected to be valid even when the interaction is slowly decaying with distance.Comment: 4 pages, 5 figure

Characterization of RNA sequence determinants and antideterminants of processing reactivity for a minimal substrate of Escherichia coli ribonuclease III

Members of the ribonuclease III family are the primary agents of double-stranded (ds) RNA processing in prokaryotic and eukaryotic cells. Bacterial RNase III orthologs cleave their substrates in a highly site-specific manner, which is necessary for optimal RNA function or proper decay rates. The processing reactivities of Escherichia coli RNase III substrates are determined in part by the sequence content of two discrete double-helical elements, termed the distal box (db) and proximal box (pb). A minimal substrate of E.coli RNase III, μR1.1 RNA, was characterized and used to define the db and pb sequence requirements for reactivity and their involvement in cleavage site selection. The reactivities of μR1.1 RNA sequence variants were examined in assays of cleavage and binding in vitro. The ability of all examined substitutions in the db to inhibit cleavage by weakening RNase III binding indicates that the db is a positive determinant of RNase III recognition, with the canonical UA/UG sequence conferring optimal recognition. A similar analysis showed that the pb also functions as a positive recognition determinant. It also was shown that the ability of the GC or CG bp substitution at a specific position in the pb to inhibit RNase III binding is due to the purine 2-amino group, which acts as a minor groove recognition antideterminant. In contrast, a GC or CG bp at the pb position adjacent to the scissile bond can suppress cleavage without inhibiting binding, and thus act as a catalytic antideterminant. It is shown that a single pb+db ‘set’ is sufficient to specify a cleavage site, supporting the primary function of the two boxes as positive recognition determinants. The base pair sequence control of reactivity is discussed within the context of new structural information on a post-catalytic complex of a bacterial RNase III bound to the cleaved minimal substrate