Additional file 1: of DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder

Table S1. Sample demographic information for the individuals included in this study. Table S2. Comparison of 12 normalisation methods. Table S3. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of individuals carrying the linked haplotype (LH) and married in controls (MI), ranked by p-value. Table S4. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of affected individuals carrying the linked haplotype (ALH) and married in controls (MI), ranked by p-value. Table S5. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of unaffected individuals carrying the linked haplotype (ULH) and married in controls (MI), ranked by p-value. Table S6. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of affected individuals carrying the linked haplotype (ALH) and unaffected carriers of the linked haplotype (ULH), ranked by p-value. Table S7. Differentially methylated regions (DMRs) identified in affected carriers of the linked haplotye(ALH) compared to married in controls (MI), ranked by p-value. Table S8. Differentially methylated regions (DMRs) identified in carriers of the linked haplotye (LH) compared to married in controls (MI), ranked by p-value. Table S9. Differentially methylated regions (DMRs) identified in unaffected carriers of the linked haplotye (ULH) compared to married in controls (MI), ranked by p-value. Table S10. Differentially methylated regions (DMRs) identified in affected carriers of the linked haplotye (ALH) compared to unaffected carriers of the linked haplotype (ULH), ranked by p-value. Table S11. Significantly enriched molecular process gene ontology (GO) categories identified in the ALH vs. MI comparison. Table S12. Significantly enriched biological function gene ontology (GO) categories identified in the ALH vs. MI comparison. Table S13. Significantly enriched cellular component gene ontology (GO) categories identified in the ALH vs. MI comparison. Table S14. Significantly enriched molecular process gene ontology (GO) categories identified in the ULH vs. MI comparison. Table S15. Significantly enriched biological function gene ontology (GO) categories identified in the ULH vs. MI comparison. Table S16. Significantly enriched cellular component gene ontology (GO) categories identified in the ULH vs. MI comparison. Table S17. Significantly enriched molecular process gene ontology (GO) categories identified in the ALH vs. ULH comparison. Table S18. Significantly enriched biological function gene ontology (GO) categories identified in the ALH vs. ULH comparison. Table S19. Significantly enriched molecular process gene ontology (GO) categories identified in the LH vs. MI comparison. Table S20. Significantly enriched biological function gene ontology (GO) categories identified in the LH vs. MI comparison. Table S21. Significantly enriched cellular component gene ontology (GO) categories identified in the LH vs. MI comparison. Table S22. Details of the qRT-PCR assays used to measure the seven reference genes assessed for the stability of their expression using geNorm [75]. XLSX 8646 kb

Additional file 2: of Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease

Figure S1. Position of the pyrosequencing assays for the genes LAMB1, IL6ST, and IKZF1 in the genome relative to CpG islands, annotated promoters, and exons. (PDF 523 kb