XRD profiles of various silks. from Analysing the structure and glass transition behaviour of silks for archaeology and conservation

Fig. S2 (a) XRD profiles of glass slide as sample base (i) and various types of silk fabrics: library gauze silk (ii); commercial fine silk (iii); UV-aged fine silk (iv); starch-coated fine silk (v) and UV-aged starch-coated fine silk (vi); (b) Overlay of the three curves (ii), (iii) and (iv) in the grey rectangle from (a)

Example of FTIR spectra peak deconvolution for the Amide I region of silks. from Analysing the structure and glass transition behaviour of silks for archaeology and conservation

Fig. S1 An example of FTIR spectrum peak deconvolution for the Zhejiang Raw silk. The figure shows the five main peaks deconvoluted from the Amide I region of the spectrum. Below shows the peak deconvolution results including peak amplitude and centre position etc

Spider Silk: Mother Nature’s Bio-Superlens

It was recently discovered that transparent microspheres and cylinders can function as a super-resolution lens (i.e., superlens) to focus light beyond the diffraction limit. A number of high-resolution applications based on these lenses have been successfully demonstrated and span nanoscopy, imaging, and spectroscopy. Fabrication of these superlenses, however, is often complex and requires sophisticated engineering processes. Clearly an easier model candidate, such as a naturally occurring superlens, is highly desirable. Here, we report for the first time a biological superlens provided by nature: the minor ampullate spider silk spun from the <i>Nephila</i> spider. This natural biosuperlens can distinctly resolve 100 nm features under a conventional white-light microscope with peak wavelength at 600 nm, attaining a resolution of λ/6 that is well beyond the classical limit. Thus, our work opens a new door to develop biology-based optical systems that may provide a new solution to integrating optics in biological systems

Additional file 3: of ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration

Table of qRT-PCR Primer Sequences. Histopathological information on adenoma samples and matching normal mucosa. Age ranges of patients 57–79. Samples listed in order from top to bottom in Fig 2F. (TXT 552 bytes

Additional file 1: of ROR2 is epigenetically inactivated in the early stages of colorectal neoplasia and is associated with proliferation and migration

COBRA of CRC cell lines showing methylation in majority of samples. COBRA assays on 31 colorectal cancer cell lines reveals that 26 of the cell lines possessed some level of ROR2 methylation. (EPS 3931 kb