Period-specific one year risk of end-stage renal disease.

<p>Multivariable logistic regression model adjusted for patient age, gender, dialysis modality, comorbidity, surgery, sepsis, mechanical ventilation, and circulatory support.</p

Flow chart depicting study design and exclusion criteria.

<p>Flow chart depicting study design and exclusion criteria.</p

Dialysis-Requiring Acute Kidney Injury in Denmark 2000-2012: Time Trends of Incidence and Prevalence of Risk Factors—A Nationwide Study

<div><p>Introduction</p><p>Dialysis-requiring acute kidney injury is a severe illness associated with poor prognosis. However, information pertaining to incidence rates and prevalence of risk factors remains limited in spite of increasing focus. We evaluate time trends of incidence rates and changing patterns in prevalence of comorbidities, concurrent medication, and other risk factors in nationwide retrospective cohort study.</p><p>Materials and Methods</p><p>All patients with dialysis-requiring acute kidney injury were identified between January 1^st 2000 and December 31^st 2012. By cross-referencing data from national administrative registries, the association of changing patterns in dialysis treatment, comorbidity, concurrent medication and demographics with incidence of dialysis-requiring acute kidney injury was evaluated.</p><p>Results</p><p>A total of 18,561 adult patients with dialysis-requiring AKI were identified between 2000 and 2012. Crude incidence rate of dialysis-requiring AKI increased from 143 per million (95% confidence interval, 137–144) in 2000 to 366 per million (357–375) in 2006, and remained stable hereafter. Notably, incidence of continuous veno-venous hemodialysis (CRRT) and use of acute renal replacement therapy in elderly >75 years increased substantially from 23 per million (20–26) and 328 per million (300–355) in 2000, to 213 per million (206–220) and 1124 per million (1076–1172) in 2012, respectively. Simultaneously, patient characteristics and demographics shifted towards increased age and comorbidity.</p><p>Conclusions</p><p>Although growth in crude incidence rate of dialysis-requiring AKI stabilized in 2006, continuous growth in use of CRRT, and acute renal replacement therapy of elderly patients >75 years, was observed. Our results indicate an underlying shift in clinical paradigm, as opposed to unadulterated growth in incidence of dialysis-requiring AKI.</p></div

Period-specific baseline azotemia and lactate parameters.

<p>Period-specific baseline azotemia and lactate parameters.</p

Flow chart depicting study design.

<p>Flow chart depicting study design.</p

Age-stratified incidence per million of dialysis-requiring acute kidney injury in Denmark between 2000 and 2012.

<p>Boxplot with 95% CI and regressions.</p

Crude incidence rate per million and frequency of dialysis-requiring acute kidney injury in Denmark between 2000 and 2012.

<p>Incidence rate shown as boxplot with 95% CI and regression, and frequency shown as a histogram.</p

Trends in One-Year Outcomes of Dialysis-Requiring Acute Kidney Injury in Denmark 2005-2012: A Population-Based Nationwide Study

<div><p>Background</p><p>Dialysis-requiring acute kidney injury (AKI) is associated with substantial mortality and risk of end-stage renal disease (ESRD). Despite considerable growth in incidence of severe AKI, information pertaining to trends in outcomes remains limited. We evaluated time trends in one year risks of ESRD and death in patients with dialysis-requiring AKI over an eight year period in Denmark.</p><p>Methods</p><p>In a retrospective nationwide study based on national registers, all adults requiring acute renal replacement therapy between 2005 and 2012 were identified. Patients with preceding ESRD were excluded. Through individual-level cross-referencing of administrative registries, information pertaining to comorbidity, preceding surgical interventions, and concurrent other organ failure and sepsis was ascertained. Comparisons of period-specific one year odds ratios for ESRD and death were calculated in a multiple logistic regression model.</p><p>Results</p><p>A total of 13,819 patients with dialysis-requiring AKI were included in the study. Within one year, 1,017 (7.4%) patients were registered with ESRD, and 7,908 (57.2%) patients died. The one-year rate of ESRD decreased from 9.0% between 2005 and 2006 to 6.1% between 2011 and 2012. Simultaneously, the one-year mortality rate decreased from 58.2% between 2005 and 2006 to 57.5% between 2011 and 2012. Consequently, the adjusted odds ratios for the period 2011–2012 (with the period 2005–2006 as reference) were 0.75 (0.60–0.95, p = 0.015) and 0.87 (95% CI 0.78–0.97, p = 0.010) for ESRD and death, respectively.</p><p>Conclusions</p><p>In a nationwide retrospective study on time trends in one year outcomes following dialysis-requiring AKI, risk of all-cause mortality and ESRD decreased over a period of 8 years.</p></div

Period-specific one-year risk of death.

<p>Multivariable logistic regression model adjusted for patient age, gender, dialysis modality, comorbidity, surgery, sepsis, mechanical ventilation, and circulatory support.</p

Incidence of surgical and non-surgical dialysis-requiring acute kidney injury per million in Denmark between 2000 and 2012.

<p>Incidence rate shown as boxplot with 95% CI and regressions, and frequency shown as a histogram.</p