State detection using coherent Raman repumping and two-color Raman transfers

We demonstrate state detection based on coherent Raman repumping and a two-color Raman state transfer. The Raman coupling during detection selectively eliminates unwanted dark states in the fluorescence cycle without compromising the immunity of the desired dark state to off-resonant scattering. We demonstrate this technique using $^{137}\mathrm{Ba}^+$ where a combination of Raman coupling and optical pumping leaves the $D_{3/2}$ $\ket{F"=3,m_F"=3}$ metastable state optically dark and immune to off-resonant scattering. All other states are strongly coupled to the upper $P_{1/2}$ levels. We achieve a single shot state-detection efficiency of $89.6(3)$ in a $1\mathrm{ms}$ integration time, limited almost entirely by technical imperfections. Shelving to the $\ket{F"=3,m_F"=3}$ state before detection is performed via a two-color Raman transfer with a fidelity of $1.00(3)$

Motor dysfunctions in ADHD and DCD: an examination of the error correction mechanisms

A high incidence of overlap between ADHD and DCD suggests that they may be related. However, different deficits may underlie the disorders. ADHD has response inhibition deficit whereas DCD has efference copy deficit. The present study examines the presence of these deficits in the respective disorders and within the ADHD subtypes. The ability of children to amend their hand movements during target perturbation is investigated in a double-step tracking task. Participants were children aged 10 to 12. The ADHD symptoms were screened by Australian Disruptive Behaviours Scale, Conner's Parent Rating Scale-Revised:L and Conner's Parent Rating Scale-Revised:L; DCD symptoms were screened by Developmental Coordination Disorder Questionnaire and McCarrson Assessment of Neuromuscular Development measure. ADHD-PI only, ADHD-C only, ADHD-PI with DCD, ADHD-C with DCD, DCD only, and a comparison group were studied. The participants were required to capture a target that skipped twice in succession. Compared to other groups, control children were able to adjust the initial response amplitude as a function of the time between a superseding stimulus and initiation of a response. The corrective response furthermore was accurate with respect to the final step position. The results are discussed in terms of an error averaging mechanism underlying tracking performance

The use of the Developmental Coordination Disorder Questionnaire in Australian children

The effectiveness of the Developmental Coordination Disorder Questionnaire (DCDQ) as a screening tool was investigated in an Australian sample. Using the DCDQ, 129 children aged 9 to 12 years old were screened for Developmental Coordination Disorder (DCD), with a follow-up assessment of movement ability using the McCarron Assessment of Neuromuscular Development (MAND) as the criterion measure. The overall decision agreement between the two measures in identifying DCD was .64. The DCDQ had a sensitivity of .55 and a specificity of .74. The low sensitivity suggests that many children with DCD are not being identified by the DCDQ despite the inclusion of children with a suspect score on the DCDQ. As a screening tool, the DCDQ was accurate in identifying children with moderate or severe DCD but identified less than half of the children with mild DCD

ADHD and DCD comorbidity: the associated problems

Attention Deficit-Hyperactivity Disorder (ADHD) has a high comorbidity with Development Coordination Disorder (DCD). On their own, these disorders are often associated with many other behavioural and emotional problems. However, studies investigating associated problems in this comorbid group are limited. This study examined these associated problems in children with comorbid ADHD and DCD using the Conners' Parent and Teachers' Rating Scales (CPRS-R:L; CTRS-R:L). A total of 109 participants (82 males; 27 females) with age ranging from 9.8 to 12.7 (M=11.16; SD=0.79) participated in this study. Participants were placed into 4 groups: Controls (n=41), ADHD (n=29), DCD (n=17) and comorbid ADHD/DCD (n=22), based on the scores from the Australian Disruptive Behaviours Scale, the Developmental Coordination Disorder Questionnaire and the McCarron Assessment Neuromuscular Development measure. A multivariate analysis of variance was conducted on the parent-rated and the teacher-rated Conners' test variables Anxious-Shy, Perfectionism, Social Problems and Psychosomatic separately. Results revealed that parents reported significant social problems seen in children with ADHD and comorbid ADHD/DCD. These children have few friends, experience low self-esteem and self-confidence, and they also feel emotionally distant from peers. However, teachers only reported significant social problems seen in children with comorbid ADHD/DCD. In addition, parents reported significant psychosomatic symptoms seen in children with ADHD. No significant group differences were found for the variables Anxious-Shy and Perfectionism. These findings imply that children with comorbid ADHD/DCD experience more significant social problems compared to children with only ADHD or DCD

The use of the Developmental Coordination Disorder Questionnaire in Australian children

The effectiveness of the Developmental Coordination Disorder Questionnaire (DCDQ) as a screening tool was investigated in an Australian sample. Using the DCDQ, 129 children aged 9 to 12 years old were screened for Developmental Coordination Disorder (DCD), with a follow-up assessment of movement ability using the McCarron Assessment of Neuromuscular Development (MAND) as the criterion measure. The overall decision agreement between the two measures in identifying DCD was .64. The DCDQ had a sensitivity of .55 and a specificity of .74. The low sensitivity suggests that many children with DCD are not being identified by the DCDQ despite the inclusion of children with a suspect score on the DCDQ. As a screening tool, the DCDQ was accurate in identifying children with moderate or severe DCD but identified less than half of the children with mild DCD

Motor dysfunctions in ADHD and DCD: an examination of the error correction mechanisms

A high incidence of overlap between ADHD and DCD suggests that they may be related. However, different deficits may underlie the disorders. ADHD has response inhibition deficit whereas DCD has efference copy deficit. The present study examines the presence of these deficits in the respective disorders and within the ADHD subtypes. The ability of children to amend their hand movements during target perturbation is investigated in a double-step tracking task. Participants were children aged 10 to 12. The ADHD symptoms were screened by Australian Disruptive Behaviours Scale, Conner's Parent Rating Scale-Revised:L and Conner's Parent Rating Scale-Revised:L; DCD symptoms were screened by Developmental Coordination Disorder Questionnaire and McCarrson Assessment of Neuromuscular Development measure. ADHD-PI only, ADHD-C only, ADHD-PI with DCD, ADHD-C with DCD, DCD only, and a comparison group were studied. The participants were required to capture a target that skipped twice in succession. Compared to other groups, control children were able to adjust the initial response amplitude as a function of the time between a superseding stimulus and initiation of a response. The corrective response furthermore was accurate with respect to the final step position. The results are discussed in terms of an error averaging mechanism underlying tracking performance

Spectroscopy on a single trapped 137Ba+ ion for nuclear magnetic octupole moment determination

We present precision measurements of the hyperfine intervals in the 5D3/2 manifold of a single trapped Barium ion, 137 Ba+ . Measurements of the hyperfine intervals are made between mF = 0 sublevels over a range of magnetic fields allowing us to interpolate to the zero field values with an accuracy below a few Hz, an improvement on previous measurements by three orders of magnitude. Our results, in conjunction with theoretical calculations, provide a 30-fold reduction in the uncertainty of the magnetic dipole (A) and electric quadrupole (B) hyperfine constants. In addition, we obtain the magnetic octupole constant (C) with an accuracy below 0.1 Hz. This gives a subsequent determination of the nuclear magnetic octupole moment, {\Omega}, with an uncertainty of 1% limited almost completely by the accuracy of theoretical calculations. This constitutes the first observation of the octupole moment in 137 Ba+ and the most accurately determined octupole moment to date.Comment: 4 pages, 3 figure

A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases.

We describe the presentation, management, and clinical outcome of a massive acinic cell carcinoma of the parotid gland. The primary tumor and blood underwent exome sequencing which revealed deletions in CDKN2A as well as PPP1R13B, which induces p53. A damaging nonsynonymous mutation was noted in EP300, a histone acetylase which plays a role in cellular proliferation. This study provides the first insights into the genetic underpinnings of this cancer. Future large-scale efforts will be necessary to define the mutational landscape of salivary gland malignancies to identify therapeutic targets and biomarkers of treatment failure