Tetra­kis(N,N-diethyl­carbamato)titanium(IV)

The mononuclear title compound, [Ti(C5H10NO2)4], is a rare example of an eight-coordinate TiIV compound in which all donor atoms are O atoms. The coordination geometry around TiIV is pseudo-dodeca­hedral and the O—C—O angles of the carbamate ligands are slightly compressed [range 115.3 (2)–116.7 (2)°], apparently on account of the high coordination number. One ethyl group is disordered over two positions; the site occupancy factors are 0.64 and 0.36

Di-μ-chlorido-bis­[dichlorido(N,N-diethyl­acetamidinato)(N,N-diethyl­acetamidine)titanium(IV)] acetonitrile disolvate

In the centrosymmetric title compound [Ti2Cl6(C6H13N2)2(C6H14N2)2]·2C2H3N, an inversion center relates the two Ti atoms which display a distorted octa­hedral coordination geometry. There are two uncoordinated acetonitrile solvent mol­ecules per mol­ecule of title compound in the crystal structure

Development of a Safe and Efficient Two-Step Synthesis for Preparing 1-Bromoacetyl-3,3-dinitroazetidine, a Novel Clinical Anticancer Candidate

An efficient process for synthesizing and isolating a new investigative anticancer agent, 1-bromoacetyl-3,3-dinitroazetidine, is described. The reaction entails a sequence of oxidative nitration followed by acylative dealkylation. The methods reported give 50–60-g batches of high-purity product without a designated purification step. The reaction conditions have been designed to mitigate the safety concerns associated with <i>gem</i>-dinitroazetidines. Some observations on the acylative dealkylation mechanism are discussed