Diagnosis of DC Bias in Power Transformers Using Vibration Feature Extraction and a Pattern Recognition Method

DC bias is a great threat to the safe operation of power transformers. This paper deals with a new vibration-based technique to diagnose DC bias in power transformers. With this technique, the DC bias status of power transformers can be automatically recognized. The vibration variation process of a 500 kV autotransformer is tested under the influence of DC bias in the monopole trail operation stage of a ±800 kV HVDC transmission system. Comparison of transformer vibration under normal and DC-biased conditions is conducted. Three features are proposed and are validated by sensitivity analysis. The principal component analysis method is employed for feature de-correlation and dimensionality reduction. The least square support vector machine algorithm is used and verified successful in DC bias recognition. A remote on-line monitoring device based on the proposed algorithm is designed and applied in field DC bias diagnosis of power transformers. The suggested diagnostic algorithm and monitoring device could be useful in targeted DC bias control and improving the safe operation level of power transformers

Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives

A series of schizonepetin derivatives have been designed and synthesized in order to obtain potent antivirus agents. The antiviral activity against HSV-1 and influenza virus H3N2 as well as the cytotoxicity of these derivatives was evaluated by using cytopathic effect (CPE) inhibition assay in vitro. Compounds M2, M4, M5 and M34 showed higher inhibitory activity against HSV-1 virus with the TC50 values being in micromole. Compounds M28, M33, and M35 showed higher inhibitory activity against influenza virus H3N2 with their TC50 values being 96.4, 71.0 and 75.4 μM, respectively. Preliminary biological activity evaluation indicated that the anti-H3N2 and anti-HSV-1 activities improved obviously through the introduction of halogen into the structure of schizonepetin

Research on splitting criterion of the power system with wind-storage system integrated

As the last defense line of the power system, splitting control is of great significance to the safety and stability of power grid. However, with the increasing penetration of wind power, photovoltaic, energy storage and other power electronic power sources in the grid, the transient stability of the power system is seriously affected. Meanwhile, the operation characteristics of power electronic power source are very different from that of traditional synchronous generator. The integration of power electronic power source affects the characteristics about out-of-step oscillation, and ultimately affects the safe implementation of splitting control. In order to split the power system more adaptably, a new splitting control method is proposed in this paper. Firstly, the equivalent external characteristic model of the wind-storage system is derived, and the influence of the wind-storage system on the out-of-step center is analyzed. Secondly, according to the out-of-step oscillation characteristics when the wind-storage system is integrated, line weak-connection index(LWcI) is proposed to evaluate the stability margin of the branch. Thirdly, according to the trajectory difference about LWcI-Δθin all branches when it is unstable and stable, we propose the splitting control criterion based on LWcI-Δθand the phase angle of voltage about the branch. Finally, the effectiveness and adaptability of the splitting criterion proposed in this paper are verified by simulation analysis of the improved IEEE-39 system

Anti-inflammatory and analgesic actions of bufotenine through inhibiting lipid metabolism pathway

Inflammation is a primary defense and immune response. However, under pathological conditions, the inflammation processes always become uncontrolled and lead to chronic diseases. Bufotenine, as a natural component from toad venom, showed great potential for development as a novel anti-inflammation and analgesia agent. This study aimed to investigate the therapeutic effects of bufotenine against inflammation and pain on animal models with a focus on lipid metabolism. In pharmacological studies, bufotenine significantly inhibited the swelling rates on formalin-induced paw edema model, and increased paw withdrawal mechanical thresholds (PWMTs) in von Frey test and thermal pain thresholds (TPTs) in hot-plate test. High-sensitivity lipidomics analysis revealed the effects might be related to the down-regulation of inflammatory mediators from cyclooxygenase (COX), lipoxygenase (LOX), cytochrome P450 (CYP450), linoleic acid (LA), docosahexaenoic acid (DHA) and other pathways. The activities might result from the binding of bufotenine and its receptors, including sigma-1 receptor and 5-Hydroxytryptamine receptor 3A, thus regulating lipid metabolism pathway. The research provided a systemic evidence for the actions and mechanism of bufotenine. It suggested that the natural compound might be a potential candidate for reducing inflammatory pain disorders

AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

Abstract Background Currently, multiple myeloma (MM) is still an incurable plasma cell malignancy in urgent need of novel therapeutic targets and drugs. Methods Bufalin was known as a highly toxic but effective anti-cancer compound. We used Bufalin as a probe to screen its potential targets by proteome microarray, in which AHSA1 was the unique target of Bufalin. The effects of AHSA1 on cellular proliferation and drug resistance were determined by MTT, western blot, flow cytometry, immunohistochemistry staining and xenograft model in vivo. The potential mechanisms of Bufalin and KU-177 in AHSA1/HSP90 were verified by co-immunoprecipitation, mass spectrometry, site mutation and microscale thermophoresis assay. Results AHSA1 expression was increased in MM samples compared to normal controls, which was significantly associated with MM relapse and poor outcomes. Furthermore, AHSA1 promoted MM cell proliferation and proteasome inhibitor (PI) resistance in vitro and in vivo. Mechanism exploration indicated that AHSA1 acted as a co-chaperone of HSP90A to activate CDK6 and PSMD2, which were key regulators of MM proliferation and PI resistance respectively. Additionally, we identified AHSA1-K137 as the specific binding site of Bufalin on AHSA1, mutation of which decreased the interaction of AHSA1 with HSP90A and suppressed the function of AHSA1 on mediating CDK6 and PSMD2. Intriguingly, we discovered KU-177, an AHSA1 selective inhibitor, and found KU-177 targeting the same site as Bufalin. Bufalin and KU-177 treatments hampered the proliferation of flow MRD-positive cells in both primary MM and recurrent MM patient samples. Moreover, KU-177 abrogated the cellular proliferation and PI resistance induced by elevated AHSA1, and decreased the expression of CDK6 and PSMD2. Conclusions We demonstrate that AHSA1 may serve as a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

Recent progress on the total synthesis of acetogenins from Annonaceae

An overview of recent progress on the total synthesis of acetogenins from Annonaceae during the past 12 years is provided. These include mono-tetrahydrofurans, adjacent bis-tetrahydrofurans, nonadjacent bis-tetrahydrofurans, tri-tetrahydrofurans, adjacent tetrahydrofuran-tetrahydropyrans, nonadjacent tetrahydrofuran-tetrahydropyrans, mono-tetrahydropyrans, and acetogenins containing only γ-lactone. This review emphasizes only the first total synthesis of molecules of contemporary interest and syntheses that have helped to correct structures. In addition, some significant results on the novel synthesis and structure–activity relationship studies of annonaceous acetogenins are also introduced