7 research outputs found
Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
Upon publication of the original article [1], it was noticed that the
author\u2019s name \u201cJean Jacques Noubiap\u201d was incorrectly
given as \u201cJean Jacques N. Noubiap\u201d. This has now been
acknowledged and corrected in this erratum
Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
Objective: This study aimed at investigating the association between
the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a
Cameroonian population. Method: This was a case-control pilot study
including 61 obese and 61 non-obese Cameroonian adults. Anthropometric
indices of obesity, blood pressure, fasting blood glucose, and blood
lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2
gene was genotyped using polymerase chain reaction-restriction fragment
length polymorphism (PCR-RFLP), and genotypes were correlated with
clinical and biological parameters. Results: The T allele was
predominant in the study population with a frequency of 93%. No
statistically significant difference was however observed between the
genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and
non-obese subjects. Comparison of clinical and biochemical parameters
of C allele carriers (CX = CC + CT) with those of TT genotype showed
that there was no significant difference between the lipid profile of
these two groups. Conclusion: The rs7903146 (C/T) polymorphism of the
TCF7L2 gene might not be associated with obesity in the Cameroonian
population
Erratum to: Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study
OBJECTIVE: This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. METHOD: This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. RESULTS: The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. CONCLUSION: The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population
Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study.
10.1186/s40169-015-0058-1Clin Transl Med4117