Treatment of Vivax Malaria in Vietnam

Globally, relapse caused by Plasmodium vivax malaria is estimated to contribute approximately 50% to the overall number of vivax infections. In South-East Asia, relapse rates commonly exceed 50%, making relapse as the main source of vivax illness. Recurrent episodes of febrile illness and hemolysis inflict a significant public health burden particularly in vulnerable groups such as pregnant women and young children. Multiple relapses may contribute substantially to the delayed morbidity and unappreciated mortality relative to falciparum malaria. Therefore, the radical cure of P. vivax malaria requires a combination of both blood schizontocides to achieve acute clinical cure, and hypnozoiticides to prevent relapses in the future. The World Health Organization (WHO) recommends the standard 14-day primaquine regimen in curing and preventing relapse from vivax malaria. Another 8-aminoquinoline derivative with prolonged elimination half-life, tafenoquine, also propose an alternative choice in radical therapy. The main research question is: what is the most effective treatment to achieve radical cure of Plasmodium vivax in Vietnam? In order to answer this question a series of studies and clinical trials were conducted in Vietnam and our findings point to these conclusions: 1/ The short 7-day course of primaquine is an available, safe and highly efficacious antirelapse treatment that could improve the adherence of patients and hence the effectiveness of radical cure of vivax relapse. 2/ The single dose of 300 mg tafenoquine, an 8-aminoquinoline drug, has similar antirelapse activity compared to primaquine. When administered with chloroquine, this hypnozoiticidal agent is a potential candidate in the malaria elimination era. 3/ The prevalence and variants of G6PD deficiency determinants of hemolytic toxicity of 8-aminoquinolines in malaria endemic regions represent important factors to be considered when implementing radical cure of latent vivax malaria

Effects of Grain Magnetic Properties and Grain Growth on Synthetic Dust Polarization of MHD Simulations in Protostellar Environments

Thermal dust polarization is a powerful tool to probe magnetic fields ($\textbf{B}$) and grain properties. However, a systematic study of the dependence of dust polarization on grain properties in protostellar environments is not yet available. In this paper, we post-process a non-ideal MHD simulation of a collapsing protostellar core with our updated POLARIS code to study in detail the effects of iron inclusions and grain growth on thermal dust polarization. We found that superparamagnetic (SPM) grains can produce high polarization degree of $p \sim 10-40\%$ beyond $\sim 500$ au from the protostar because of their efficient alignment by magnetically enhanced Radiative Torque mechanism. The magnetic field tangling by turbulence in the envelope causes the decrease in $p$ with increasing emission intensity $I$ as $p\propto I^{\alpha}$ with the slope $\alpha \sim -0.3$. But within 500 au, SPM grains tend to have inefficient internal alignment (IA) and be aligned with $\textbf{B}$ by RATs only, producing lower $p \sim 1\%$ and a steeper slope of $\alpha \sim -0.6$. For paramagnetic (PM) grains, the alignment loss of grains above $1\mu m$ in the inner $\sim 200$ au produces $p << 1\%$ and the polarization hole with $\alpha \sim -0.9$. Grain growth can increase $p$ in the envelope for SPM grains, but cause stronger depolarization for SPM grains in the inner $\sim 500$ au and for PM grains in the entire protostellar core. Finally, we found the increase of polarization angle dispersion function $S$ with iron inclusions and grain growth, implying the dependence of B-field strength measured using the DCF technique on grain alignment and grain properties.Comment: Accepted to MNRAS. 31 pages, 23 figures, 13 pages in Appendi

A Framework for Task-Based Flipped Classroom in EFL Education in Vietnam

When it comes to language teaching in general education in Vietnam, there are many challenges for teachers to overcome. Such as time constraints, examination wash-back effects, students’ demotivation and students’ individualization causes of learning. Various innovative teaching methods and approaches have been applied to address these concerns, such as task-based language learning and flipped classrooms (FCs). However, each mode of teaching has its advantages and disadvantages. Due to this, it is essential to carefully examine the combination of TBLT and the flipped classroom (FC). This paper reviews the effects of the implementation of task-based language learning in the clipped classroom, discusses the integration of both teaching approaches, and suggests the applied model for English as a Foreign Language (EFL) education in Vietnam

Stability of twin circular tunnels in cohesive-frictional soil using the node-based smoothed finite element method (NS-FEM)

This paper presents an upper bound limit analysis procedure using the node-based smoothed finite element method (NS-FEM) and second order cone programming (SOCP) to evaluate the stability of twin circular tunnels in cohesive-frictional soils subjected to surcharge loading. At first stage, kinematically admissible displacement fields of the tunnel problems are approximated by NS-FEM using triangular elements (NS-FEM-T3). Next, commercial software Mosek is employed to deal with the optimization problems, which are formulated as second order cone. Collapse loads as well as failure mechanisms of plane strain tunnels are obtained directly by solving the optimization problems. For twin circular tunnels, the distance between centers of two parallel tunnels is the major parameter used to determine the stability. In this study, the effects of mechanical soil properties and the ratio of tunnel diameter and the depth to the tunnel stability are investigated. Numerical results are verified with those available to demonstrate the accuracy of the proposed method

Occurrence and dissipation of the antibiotics sulfamethoxazole, sulfadiazine, trimethoprim, and enrofloxacin in the Mekong Delta, Vietnam

The Mekong Delta in Vietnam has seen a rapid development and intensification of aquaculture in the last decades, with a corresponding widespread use of antibiotics. This study provides information on current antibiotic use in freshwater aquaculture, as well as on resulting antibiotic concentrations in the aquatic environment of the Mekong Delta. Two major production steps, fish hatcheries and mature fish cultivation, were surveyed (50 fish farm interviews) for antibiotic use. Different water sources, including surface water, groundwater and piped water (164 water samples) were systematically screened for antibiotic residues. To better understand antibiotic fate under tropical conditions, the dissipation behavior of selected antibiotics in the aquatic environment was investigated for the first time in mesocosm experiments. None of the investigated antibiotics were detected in groundwater and piped water samples. Surface water, which is still often used for drinking and domestic purposes by local populations, contained median concentrations of 21 ng L-1 sulfamethoxazole (SMX), 4 ng L-1 sulfadiazine (SDZ), 17 ng L-1 trimethoprim (TRIM), and 12 ng L-1 enrofloxacin (ENRO). These concentrations were lower than the predicted no effect concentrations (PNECs) and minimum inhibitory concentrations (MICs), suggesting limited antibiotic-related risk to aquatic ecosystems in the monitored systems. The dissipation half-lives of the studied antibiotics ranged from &#60;1 to 44 days, depending on the availability of sunlight and sediment. Among the studied antibiotics TRIM was the most persistent in water systems. TRIM was not susceptible to photodegradation, while the dissipation of ENRO and SDZ was influenced by photolysis. The recorded dissipation models gave good predictions of the occurrence and concentrations of TRIM, ENRO and SDZ in surface water. In summary, the currently measured concentrations of the investigated antibiotics are unlikely to cause immediate risks to the aquatic environment, yet the persistence of these antibiotics is of concern and might lead to chronic exposure of aquatic organisms as well as humans

Numerical modeling of thermal dust polarization from aligned grains in the envelope of evolved stars with updated POLARIS

Magnetic fields are thought to influence the formation and evolution of evolved star envelopes. Thermal dust polarization from magnetically aligned grains is potentially a powerful tool for probing magnetic fields and dust properties in these circumstellar environments. In this paper, we present numerical modeling of thermal dust polarization from the envelope of IK Tau using the magnetically enhanced radiative torque (MRAT) alignment theory implemented in our updated POLARIS code. Due to the strong stellar radiation field, the minimum size required for RAT alignment of silicate grains is $\sim 0.005 - 0.05\,\rm\mu m$. Additionally, ordinary paramagnetic grains can achieve perfect alignment by MRAT in the inner regions of $r < 500\,\rm au$ due to stronger magnetic fields of $B\sim 10$ mG - 1G, producing thermal dust polarization degree of $\sim 10\,\%$. The polarization degree can be enhanced to $\sim 20-40\%$ for grains with embedded iron inclusions. We also find that the magnetic field geometry affects the alignment size and the resulting polarization degree due to the projection effect in the plane-of-sky. We also study the spectrum of polarized thermal dust emission and find the increased polarization degree toward $\lambda > 50\,\rm\mu m$ due to the alignment of small grains by MRAT. Furthermore, we investigate the impact of rotational disruption by RATs (RAT-D) and find the RAT-D effect cause a decrease in the dust polarization fraction. Finally, we compare our numerical results with available polarization data observed by SOFIA/HAWC+ for constraining dust properties, suggesting grains are unlikely to have embedded iron clusters and might have slightly elongated shapes. Our modeling results suggest further observational studies at far-infrared/sub-millimeter wavelengths to understand the properties of magnetic fields and dust in AGB envelopes.Comment: 27 pages, 23 figures, 1 table, to be submitte