Baseline demographics of the patients, all values are means (95% CI).

<p>*p test by Kruskal Wallis, except.</p><p>^{<>\raster(60%)="rg2"<>}Fisher's exact.</p>Ψ<p>Admission serum creatinine>265 µmol/L.</p>Ω<p><50 ml urine output in first 24 hours.</p>#<p>Systolic blood pressure <80 mmHg with evidence of poor end organ perfusion.</p>∧<p>Clinician's diagnosis.</p><p>MABP: Mean arterial blood pressure, PAoP: Pulmonary artery occlusion pressure, SVR: systemic vascular resistance, CvO2: mixed venous oxygen saturation. DO2: Oxygen delivery. VO2: Oxygen consumption. OER: oxygen extraction ratio.</p

Change in variables with fluid loading n = 24.

<p>MABP: mean arterial blood pressure, CVP: central venous pressure, PAoP: pulmonary artery occlusion pressure, SVR: systemic vascular resistance, SaO₂: oxygen saturation, PaO₂: partial pressure of oxygen, PaCO₂: partial pressure of carbon dioxide, CvO₂: mixed venous oxygen saturation, DO₂: oxygen delivery, VO₂: oxygen consumption, O₂er: oxygen extraction ratio.</p><p>*Median (IQR) as non-parametric distribution.</p

Correlation between ΔCVP and ΔPAoP.

<p>*Spearman's rho, p value by Spearman's.</p><p>CVP: Central venous pressure, PAoP: Pulmonary artery occlusion pressure, BD: base deficit, HCO3: Bicarbonate. CI: cardiac index, DO₂: Oxygen delivery, VO₂: oxygen consumption, O₂er: oxygen extraction ratio, CvO₂: central mixed venous oxygen saturation, MABP: mean arterial blood pressure.</p

Baseline demographics by resuscitation agent (mean (95% CI)).

<p>*p by Kruskal Wallis.</p>Ψ<p>Admission serum creatinine>265 µmol/L.</p>Ω<p><50 ml urine output in first 24 hours.</p>#<p>Systolic blood pressure <80 mmHg with evidence of poor end organ perfusion.</p>∧<p>Clinical diagnosis.</p><p>APO: Acute pulmonary oedema, MABP: mean arterial blood pressure, MPAP: Mean pulmonary artery pressure, CVP: central venous pressure, PAoP: pulmonary artery occlusion pressure, SVR: systemic vascular resistance, SaO₂: oxygen saturation, CvO₂: mixed venous oxygen saturation, DO₂: oxygen delivery, VO₂: oxygen consumption, O₂er: oxygen extraction ratio.</p

Outcomes by resuscitation agent.

<p>*p by Fisher's exact. APO: Acute pulmonary oedema,</p>∧<p>Clinical diagnosis. ARF: Acute renal failure,</p>Ψ<p>serum creatinine>265 µmol/L.</p

Response to resuscitation agents (mean Δ (95% CI)).

<p>*p by Kruskal Wallis. MABP: mean arterial blood pressure, CVP: central venous pressure, PAoP: pulmonary artery occlusion pressure, SVRI: systemic vascular resistance index, SaO2: oxygen saturation, CvO2: mixed venous oxygen saturation, DO2: oxygen delivery, VO2: oxygen consumption, O2ER: oxygen extraction ratio.</p

Management of the patients.

<p>Management of the patients.</p

Relationship between change in base deficit against change in cardiac index with fluid loading (p = 0.95 r_s = 0.01).

<p>Blue dots survivors, red dots deaths.</p

Outcome by fluid load.

<p>*p value determined by Fisher's exact. APO: Acute pulmonary oedema, CM: cerebral malaria ARF: Acute renal failure.</p>Ψ<p>serum creatinine>265 µmol/L.</p>∧<p>Clinician's diagnosis.</p>#<p>Systolic blood pressure <80 mmHg with evidence of poor end organ perfusion.</p

Relationship between baseline CVP and volume of fluid required to resuscitate patient (p = 0.87 r_s = 0.04).

<p>Blue dots survivors, red dots deaths.</p