PERBEDAAN EFEK SIMVASTATIN DAN ATORVASTATIN TERHADAP PROFIL LDL DARAH PENDERITA JANTUNG KORONER DI POLI JANTUNG RSUD DR.SOETOMO PADA TAHUN 2015

Effect Simvastatin and Atorvastatin in LDL blood profile in patients Coronary Heart Disease in RSUD Dr.Soetomo 2015. Ngurah Arie Kapindra Dharma, 011211131052. Medical Faculty of Airlangga University, Surabaya Intriduction : Dyslipidemia is a disorder of lipoprotein metabolism. This disorder is characterized by an increase in total serum cholesterol, low density lipoprotein (LDL) and decreased concentrations of high density lipoprotein (HDL). In the process of atherosclerosis, three have an important role and are closely related to each other. Dyslipidemia may cause atherosclerosis, which manifested itself in CHD, recurrent abdominal pain that is caused by elevated levels of triglycerides (TG) of blood and acute pancreatitis occurs when a life-threatening blood TG levels high enough (Ahmed, 1998). Methods: The study used the cohort observational study using a retrospective observational approach is based on the results of the medical records of patients with coronary heart disease at Hospital Dr. Soetomo, Surabaya. Results: The samples used in this study a number of 86. Average difference in LDL delta therapy for 3 months less than the delta therapy for 6 months, these shows there is an indication that the therapy 6 months can increase the delta decrease in LDL. Found also on a pair of test sample T obtained p-value of 0.013 < p 0.05. In the comparion of delta therapy atorvastatin 3 months and delta therapy simvastatin 3 months, based on the Mann-Whitney test results obtained p-value of 0.0566 where the value is greater than the value of 0:05. This indicates that the rejection of the initial hypothesis fails. Conclusion: There is a significant difference between the average delta LDL therapy for 3 months with an average delta LDL therapy for 6 months and can not be a significant difference to the value of delta after 3 months of therapy using drugs simvastatin and atorvastatin Keywords : Simvastatin – Atorvastatin – Dyslipidemia – Coronary Heart Diseas

The Impact of Facilitated Quarantine on Mental Health Status of Non-Severe COVID-19 Patients

It has been shown that quarantine is important to reduce the incidence and mortality during COVID-19 pandemic.1 However, quarantine has consequences towards mental health. From previous outbreaks, several negative psychological effects such as post-traumatic stress symptoms, confusion, and anger were observed.2 In Indonesia, several successful suicide cases of COVID-19 patients in quarantine facilities have been reported, and being quarantined in quarantine facilities has been suggested to be the main cause. Nevertheless, no study has confirmed whether being quarantined in quarantine facilities in fact, worsens the mental health status of COVID-19 patients

Clinical Characteristics of 6102 Asymptomatic and Mild Cases for Patients with COVID-19 in Indonesia

Background: The COVID-19 pandemic has led to a rise in confirmed cases, making epidemiological studies crucial for identifying the source of transmission and developing effective treatment methods. We conducted a study on the clinical characteristics of patients with asymptomatic and mild symptoms of COVID-19 at a rescue hospital in Indonesia. Methods: This is an epidemiological study involving 6102 patients who were admitted to the Indrapura forefront hospital in Surabaya from May 2020 to February 2021. We described demographic data, clinical signs and symptoms, laboratory data, therapy, and clinical outcomes. Results: A total of 6102 patients were involved in this study, with 3664 (60.04%) being male and 2438 (39.95%) being female. The age range of 21–30 years was the most prevalent, accounting for 31.1% (1898 patients). The population had 1476 patients (24.2%) with comorbid conditions. The most prevalent comorbidity observed among these patients was hypertension, affecting 1015 individuals (16.6%). Out of the total 6006 patients observed, 40.7% (n = 2486) were asymptomatic, 54.6% (n = 3329) had mild symptoms, and 3.1% (n = 191) had moderate symptoms. All patients were administered supportive therapy without the use of antiviral medication. Out of the 6102 patients included in the study, 5923 patients (97.1%) achieved a cure, 36 patients (0.6%) are currently undergoing treatment, 142 patients (2.3%) were referred for desaturation indications (SpO2 < 94%), and one patient died due to a suspected cardiovascular event. Out of the total number of patients, 74.5% (4529 patients) had an average length of stay (LOS) of less than 10 days, while 25.6% (1563 patients) had an average length of stay of more than 10 days. Conclusion: The clinical presentation of asymptomatic and mild COVID-19 patients at a rescue hospital varies significantly based on the age and sex of patients. Cough and hyposmia are commonly observed symptoms. Supportive therapy is effective, and strict implementation of social distancing is crucial in preventing the spread of this disease from individuals who are asymptomatic or have mild symptoms