Anti-spermatogenic and estrogenic effects of Escravos crude oil in Chinchilla rabbits

This study aimed at investigating the effects of Escravos crude oil on spermatogenesis in relation to serum concentrations of estradiol and total cholesterol. A total of 30 male Chinchilla rabbits within the age range of 12 to 14 weeks and weighing 1.2 kg to 1.45 kg were used in this study. The doses of 00, 15, 20, 25 and 30 mg kg-1 body weight of Escravos crude oil were orally administered to groups A, B, C, D and E, respectively for 28 days. Serum concentrations of estradiol and total cholesterol were estimated using the microplate enzyme immunoassay and enzymatic end point methods, respectively. The SPSS software package (version 16) was used for the statistical analyses and results expressed in mean ± Standard Deviation. The results showed dose dependent significant increases in estradiol (18.32 +/- 6.46 to 69.41 +/- 12.89 pg/ml) and total cholesterol (1.32 +/- 0.24 to 2.92 +/- 0.34 mmol/l) concentrations (p<0.05), and insignificant increase (p>0.05) in the relative weight of the testis (3.80 +/- 0.40 to 5.50 +/- 0.90 g). The histology of the testes revealed decreased spermatogenic activity. The findings of this study suggest that Escravos crude oil could be a potential endocrine disruptor and anti-spermatogenic agent.Keywords: Escravos crude oil, Estradiol, Anti-Spermatogenesis, Total cholesterol, Chinchilla rabbits

Iron deposition in breast carcinomas: A biopsy study of 140 cases

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Nephrotoxicity of Chloroquine in the rabbit

No Abstract Available J. Expt. & Clin. Anat Vol.3(1) 2004: 16-2

Tumors of the prostate in Enugu: Clinico-pathological considerations

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A Histologic study of well established cases of malignant melanoma to ascertain positive cases for melanin

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Pancreotoxicity of Chloroquine in the rabbit

No Abstract Available J. Expt. & Clin. Anat Vol.3(1) 2004: 29-3

Review Article: Toxic Effects of Some Reagents Used in Electron Microscopy and Histochemistry

Ultrathin sections prepared for electron microscopy and histochemistry are indispensable in cytological, histological and histochemical studies. The paper discusses the various reagents used in these fields of study. Unfortunately, these reagents and chemicals are hazardous to health. There is wisdom in informing the users of these reagents and chemicals, of the most recent findings bearing on their toxicity as well as suggesting the safety precautions to be taken in the use of these toxic reagents. In this review, a survey of published data on their toxic nature is presented. Key words: electronmicroscopy, osmic acid, formaldehyde, araldite, epoxy resin, stains Journal of Medical Laboratory Science Vol.13(1) 2004: 1 - 1

Effects Of Chloroquine On Some Visceral Organs In The Rabbit: Histopathological Perspective

The histopathological changes caused by chloroquine phosphate in doses 5, 10 and 15mg/kg over 30, 60 and 90 days in the albino (n=10) and pigmented (n=22) rabbits, with mean weight value of 1.40 ± 0.44kg and mean age value of 9.0 ± 0.25 months were investigated in the College of Medicine, University of Nigeria, Enugu Campus. Histopathology results revealed linear, granular, bumpy stainable iron deposition on the wall of the myocardium. The lymphoid organs showed prominent necrosis, fibrosis and disappearance of lymhocytes. Histology of the rabbits\' duodenum also revealed marked mucosal ulcerationand loss of villi in all treated groups. Patients of malariasis are advised to consult their physicians for drug prescription and proper guidance in chloroquine consumption to avert the toxic consequences of frequent and indiscriminate chloroquine ingestion. Key words: Heart, duodenum, lymphoid organ, ulceration, necrosis, histologyJournal of Experimental and Clinical Anatomy Vol. 4 (1) 2005: 50-5

Incidence of vaginal trichomoniasis in Enugu Metropolis and enviros: A cytologic study

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Histopathologic evaluation of cholecystopathies in Enugu State of Nigeria

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