The percentage of hepatitis B virus infection and related factors in Tra Vinh province, Vietnam

Background: Hepatitis B virus infection continues to be a public health problem in developing countries. This study aimed to assess the percentage of hepatitis B virus infection and related factors among adult population in Tra Vinh Province, Vietnam 2022. Methods: The study applied the cross-sectional descriptive design with the combination of structured interview and serological blood tests, from September 1, 2021, to June 1, 2022. Results: There were 1,289 respondents in the study. Overall, the percentage of sample positive reaction with HBsAg were 7.68% (99 peoples). Most of the people did not likely have relatives with a family history of hepatitis B virus infection, the proportion of people who had household family members who had hepatitis B, hepatocellular carcinoma, and cirrhosis was 1.24%, 0.93%, and 2.48% respectively. People who did not preventive vaccination for hepatitis B virus had higher rates of HBsAg (+) than people get preventive vaccination, with p=0.005. However, in other medical practice, the rate of HBsAg was non-significance, such as blood transfusion, surgery, dental treatment, injecting medications, and injected skin boils. The percentage of hepatitis B virus infection in the study was not significantly associated with hepatitis B prevention practices in daily life, including acupuncture, sharing shavers, sharing toothbrushes, sharing nail tools, and spraying tattoo. Conclusions: The percentage of hepatitis B virus infection in Tra Vinh province was 7.68%. There was a statistically significant relationship between the incidence of hepatitis B with preventive vaccination for the hepatitis B virus

LEARNING AWARENESS LEVEL OF NURSING STUDENTS AT TRA VINH UNIVERSITY ON CLINICAL PRACTICE ENVIRONMENT AT HOSPITAL

The purpose of the study was to examine the level of awareness about the clinical practice environment at the hospital among nursing students of Tra Vinh University in 2021. A descriptive cross-sectional study was applied to analyze the data of 205 students selected. The study results showed a positive level of awareness with an average score of 130.83±8.73. ’Interaction and participation’ had an average score of 41.6±2.99, ’Student-centered’ had an average score of 45.92±3.56, ’Allow individual participation’ had an average score of 10.53±1.82, ’Nursing work value’ had an average score of 9.11±1.11, ’Promoting learning at work’ had an average score of 16.42±2.80, and ’Lack of creativity’ had an average score of 7.23±1.48. The research results  provide implications for the further improvement of nursing training at Tra Vinh University in particular and universities and colleges with nursing training in general

FACTORS AFFECTING QUALITY OF LIFE OF PERSONS WITH TYPE 2 DIABETES OUTCOME TREATMENT AT TRA VINH UNIVERSITY HOSPITAL

The study aimed to determine the factors affecting the quality of life of patients with type 2 diabetes treated as outpatients at Tra Vinh University Hospital in 2021. The crosssectional study includes data from over 200 people with type 2 diabetes who are being treated as outpatients at Tra Vinh University Hospital. The study used direct interviews to collect data. The study managed and analyzed data using SPSS 20.0 software and the Kruskal Wallis and MannWhitney test to identify factors affecting the life quality of patients with type 2 diabetes. The results show that the overall quality of life score of diabetic patients is 62.10 ± 7.31, equivalent to the average quality of life of patients with diabetes. The results also show that the average quality of life score for participants are connected with factors including age groups, occupation, duration of disease, other comorbidities, and complications in patients. This difference is statistically significant with p < 0.001, p = 0.001, p = 0.039, p = 0.007, p = 0.008, respectively. In addition, the study did not find any difference in the mean quality of life scores by gender, education level, marital status, health insurance, household economy, people living with, BMI, glycemic index, and treatment methods

A polyhydroxylated sterol and a saponin isolated from the starfish culcita novaeguineae

Using various chromatographic methods, a polyhydroxylated sterol 5α-cholestane-3β,6β,7α,8β,15α,16β,26-heptol (1) and an asterosaponin sodium salt of 6α-[(O-β-D-fucopyranosyl-(l®2)-O-β-D-galactopyranosyl-(l®4)-O-[β-D-quinovopyranosyl-(l®2)]-O-β-D-xylopyranosyl-(l®3)-O-β-D-quinovopyranosyl)oxy]-5α-pregn-9(11)-ene-20-one (2), were isolated from the methanol extract of the starfish Culcita novaeguineae. Their structures were elucidated by 1D and 2D-NMR experiments and comparison of their NMR data with reported values. Compounds 1 was isolated from         C. novaeguineae for the first time

Asterosaponins and glycosylated polyhydroxysteroids from the starfish <i>Culcita novaeguineae</i> and their cytotoxic activities

<div><p>Using combined chromatographic methods, two asterosaponins (compounds <b>1</b> and <b>2</b>), including a new compound novaeguinoside E (compound <b>1</b>), and six glycosylated polyhydroxysteroids (compounds <b>3</b>–<b>8</b>) were isolated from a methanol extract of the starfish <i>Culcita novaeguineae</i>. Their structures were determined on the basis of spectroscopic data (¹H and ¹³C NMR, HSQC, HMBC, ¹H–¹H COSY, ROESY, and HRESI-MS) and by comparison with the literature values. The new compound <b>1</b> represents the third example of asterosaponins containing the 5α-cholesta-9(1l)-en-3β,6α,20,22-tetraol aglycone. Among isolated compounds, <b>4</b>–<b>7</b> exhibited moderate to weak cytotoxic activities against five human cancer cell lines such as Hep-G2 (hepatoma), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma).</p></div

Efficacy of compliance with ventilator-associated pneumonia care bundle: A 24-month longitudinal study at Bach Mai Hospital, Vietnam

Introduction: To decrease the risk of complications from ventilator-associated pneumonia, it is essential to implement preventative measures in all ICU patients. Since 2018, with the help of Japanese experts, we have applied a ventilator-associated pneumonia care bundle with 10 basic standards in patient care and monitoring. Therefore, we conducted a study to evaluate the results of applying 10 solutions to prevent ventilator-associated pneumonia over 24 months. Methods: A cross-sectional descriptive study with longitudinal follow-up for 24 months on 170 mechanically ventilated patients at the Center for Critical Care Medicine, Bach Mai Hospital. According to the Centers for Disease Control (CDC, 2021), the diagnosis of ventilator-associated pneumonia is when pneumonia appears 48 h after intubation by confirmation by at least two doctors. Evaluate compliance with each solution in the care bundle through camera monitoring, medical records, and directly on patients daily. Results: The rate of ventilator-associated pneumonia is 12.9%, the frequency of occurrence is 16.54 of 1000 days. The compliance rate for complete compliance with a 10-item ventilator-associated pneumonia was only 1.8%, while the average value was 84.1%. Average values of compliance with each solution for hand hygiene, head elevation 30–45 degrees, oral hygiene, stopping sedation, breathing circuit management, cuff pressure management, hypoplastic suction, Spontaneous breathing trial (SBT) daily and assessed extubation, mobilization and early leaving bed, ulcer and thrombosis prevention were 96.9%, 97.3%, 99.4%, 81.5%, 99.9%, 99.9%, 86.3%, 83.5%, 49.3%, and 46.4%, respectively. The time to appear ventilator-associated pneumonia in the high compliance group was 46.7 ± 5.0 days, higher than in the low compliance group, 10.3 ± 0.7 days, p  < 0.001. Conclusions: A 10-item ventilator-associated pneumonia care bundle has helped reduce the incidence of ventilator-associated pneumonia. To reduce the risk of ventilator-associated pneumonia and shorten ICU and hospital stays, it is essential to fully adhere to subglottic secretion suction, daily SBT, and early mobilization and leaving the bed