501 research outputs found

    What’s Happening to Linux in Singapore?

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    This paper seeks to shed some light on the progress of Linux adoption in Singapore. The paper, based upon the opinions of industry experts and two case studies (the National Library Board of Singapore and Golden Village Multiplex Pte. Ltd), clarifies key Linuxadoption issues. It further discusses the pros and cons of Linux and the challenges facing this open source rival of Microsoft Windows. The paper concludes that while Linux is likely to co-exist with Windows, it is set to make some significant changes in future IT infrastructure

    Heterogeneous photocatalysts an overview of classic and modern approaches for optical, electronic, and charge dynamics evaluation

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    The functionality of a photoactive semiconductor i.e., photocatalysts, photoelectrodes, etc. is largely dictated by three key aspects i band gap; ii absolute potentials of the conduction band minimum and the valence band maximum; and iii bulk and surface charge carrier dynamics. Their relevance to governing the energetics and the photo electro chemical mechanisms of the semiconductor has prompted development of a multitude of characterization tools to probe the specific characteristic of the material. This review aims to summarize the current experimental techniques, including the conventional and the state of the art tools, directed at examining the key aspects i , ii , and iii of semiconductors. Although not being exhaustive, this didactic review can be useful to apprise the research community of the sophisticated research tools currently available for characterization of photo electro catalyst semiconductors as well as to bridge the multidisciplinary knowledg

    Disruption of the Non-Canonical WNT Pathway in Lung Squamous Cell Carcinoma

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    Disruptions of beta-catenin and the canonical Wnt pathway are well documented in cancer. However, little is known of the non-canonical branch of the Wnt pathway. In this study, we investigate the transcript level patterns of genes in the Wnt pathway in squamous cell lung cancer using reverse-transcriptase (RT)-PCR. It was found that over half of the samples examined exhibited dysregulated gene expression of multiple components of the non-canonical branch of the WNT pathway. In the cases where beta catenin (CTNNB1) was not over-expressed, we identified strong relationships of expression between wingless-type MMTV integration site family member 5A (WNT5A)/frizzled homolog 2 (FZD2), frizzled homolog 3 (FZD3)/dishevelled 2 (DVL2), and low density lipoprotein receptor-related protein 5 (LRP5)/secreted frizzled-related protein 4 (SFRP4). This is one of the first studies to demonstrate expression of genes in the non-canonical pathway in normal lung tissue and its disruption in lung squamous cell carcinoma. These findings suggest that the non-canonical pathway may have a more prominent role in lung cancer than previously reported

    Associated Higgs production with top quarks at the Large Hadron Collider: NLO QCD corrections

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    We present in detail the calculation of the O(alpha_s^3) inclusive total cross section for the process pp -> t-tbar-h, in the Standard Model, at the CERN Large Hadron Collider with center-of-mass energy sqrt(s_H)=14 TeV. The calculation is based on the complete set of virtual and real O(alpha_s) corrections to the parton level processes q-qbar -> t-tbar-h and gg -> t-tbar-h, as well as the tree level processes (q,qbar)g -> t-tbar-h-(q,qbar). The virtual corrections involve the computation of pentagon diagrams with several internal and external massive particles, first encountered in this process. The real corrections are computed using both the single and the two cutoff phase space slicing method. The next-to-leading order QCD corrections significantly reduce the renormalization and factorization scale dependence of the Born cross section and moderately increase the Born cross section for values of the renormalization and factorization scales above m_t.Comment: 70 pages, 12 figures, RevTeX4: one word changed in the abstract, one sentence reworded in the introduction. To appear in Phys. Rev.

    Pulsar-wind nebulae and magnetar outflows: observations at radio, X-ray, and gamma-ray wavelengths

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    We review observations of several classes of neutron-star-powered outflows: pulsar-wind nebulae (PWNe) inside shell supernova remnants (SNRs), PWNe interacting directly with interstellar medium (ISM), and magnetar-powered outflows. We describe radio, X-ray, and gamma-ray observations of PWNe, focusing first on integrated spectral-energy distributions (SEDs) and global spectral properties. High-resolution X-ray imaging of PWNe shows a bewildering array of morphologies, with jets, trails, and other structures. Several of the 23 so far identified magnetars show evidence for continuous or sporadic emission of material, sometimes associated with giant flares, and a few possible "magnetar-wind nebulae" have been recently identified.Comment: 61 pages, 44 figures (reduced in quality for size reasons). Published in Space Science Reviews, "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray Bursts and Blazars: Physics of Extreme Energy Release

    Patterns with Bounded Treewidth

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    We show that any parameter of patterns that is an upper bound for the treewidth of appropriate encodings of patterns as relational structures, if restricted to a constant, allows the membership problem for pattern languages to be solved in polynomial time. Furthermore, we identify a new such parameter, called the scope coincidence degree

    A protocol developing, disseminating and implementing a core outcome set for infertility.

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    STUDY QUESTIONS: We aim to produce, disseminate and implement a core outcome set for future infertility research. WHAT IS KNOWN ALREADY: Randomized controlled trials (RCTs) evaluating infertility treatments have reported many different outcomes, which are often defined and measured in different ways. Such variation contributes to an inability to compare, contrast and combine results of individual RCTs. The development of a core outcome set will ensure outcomes important to key stakeholders are consistently collected and reported across future infertility research. STUDY DESIGN SIZE DURATION: This is a consensus study using the modified Delphi method. All stakeholders, including healthcare professionals, allied healthcare professionals, researchers and people with lived experience of infertility will be invited to participate. PARTICIPANTS/MATERIALS SETTING METHODS: An international steering group, including people with lived experience of infertility, healthcare professionals, allied healthcare professionals and researchers, has been formed to guide the development of this core outcome set. Potential core outcomes have been identified through a comprehensive literature review of RCTs evaluating treatments for infertility and will be entered into a modified Delphi method. Participants will be asked to score potential core outcomes on a nine-point Likert scale anchored between one (not important) and nine (critical). Repeated reflection and rescoring should promote convergence towards consensus 'core' outcomes. We will establish standardized definitions and recommend high-quality measurement instruments for individual core outcomes. STUDY FUNDING/COMPETING INTERESTS: This project is funded by the Royal Society of New Zealand Catalyst Fund (3712235). BWM reports consultancy fees from Guerbet, Merck, and ObsEva. R.S.L. reports consultancy fees from Abbvie, Bayer, Fractyl and Ogeda and research sponsorship from Ferring. S.B. is the Editor-in-Chief of Human Reproduction Open. The remaining authors declare no competing interests
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