6 research outputs found
Time to first stavudine toxicity (peripheral neuropathy, lipodystrophy, high lactate syndrome, pancreatitis or diabetes) in patients starting the second year of stavudine containing ART without any of these toxicities.
<p>Time to first stavudine toxicity (peripheral neuropathy, lipodystrophy, high lactate syndrome, pancreatitis or diabetes) in patients starting the second year of stavudine containing ART without any of these toxicities.</p
Analysis of changes in serum lipid levels over time.
<p>TC, total cholesterol; LDL-c, low density lipoprotein cholesterol; HDL-c, high density lipoprotein cholesterol; TG, triglyceride.</p>*<p>At the time of enrolment into the study, after 12 months of stavudine containing ART.</p
Prevalence rates at enrolment and incidence rates during 12 months of follow up of stavudine associated toxicities in 253 Malawian adults.
*<p>Prevalence at enrolment i.e. after one year of stavudine containing ART.</p>¶<p>One or more of peripheral neuropathy, lipodystrophy, pancreatitis, hyperlactate syndrome, diabetes mellitus.</p>†<p>severe hyperlactatemia, symptomatic hyperlactatemia and lactic acidosis, as defined in methods paragraph.</p><p>IR, incidence rate; PR, prevalence rate; CI, confidence interval; py, person-years; TC, total cholesterol serum level; TG, triglyceride serum level.</p
Patient characteristics.
<p>All characteristics are expressed as n (%) and are measured at enrolment, unless otherwise indicated.</p><p>All characteristics are at enrolment into the study (after one year on ART), except WHO stage and CD4 count as indicated.</p><p>IQR, inter-quartile range; BMI, body mass index; ART, antiretroviral therapy; WHO, world health organization; TB, tuberculosis; KS, Kaposi's sarcoma; eCC, estimated creatinine clearance (Cockroft-Gault method).</p
Cox regression models of variables associated with stavudine associated side effects.
¶<p>One or more of peripheral neuropathy, lipodystrophy, pancreatitis, high lactate syndrome, diabetes mellitus.</p><p>HR, hazard ratio; aHR, adjusted hazard ratio; CI, confidence interval, BMI, body mass index; WHO, world health organization; TB, tuberculosis;</p><p>eCC, estimate creatinine clearance.</p>*<p>WHO stage refers to being in WHO clinic stage 3 or 4 vs. being in stage 1 or 2 at the start of ART. Significant associations are indicated in bold font.</p>†<p>TB diagnosis refers to previous and current diagnosis.</p